SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Gensous N)
 

Sökning: WFRF:(Gensous N) > Down syndrome, acce...

Down syndrome, accelerated aging and immunosenescence

Gensous, N (författare)
Bacalini, MG (författare)
Franceschi, C (författare)
visa fler...
Garagnani, P (författare)
Karolinska Institutet
visa färre...
 (creator_code:org_t)
2020-07-23
2020
Engelska.
Ingår i: Seminars in immunopathology. - : Springer Science and Business Media LLC. - 1863-2300 .- 1863-2297. ; 42:5, s. 635-645
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Down syndrome is the most common chromosomal disorder, associated with moderate to severe intellectual disability. While life expectancy of Down syndrome population has greatly increased over the last decades, mortality rates are still high and subjects are facing prematurely a phenomenon of atypical and accelerated aging. The presence of an immune impairment in Down syndrome subjects is suggested for a long time by the existence of an increased incidence of infections, the incomplete efficacy of vaccinations, and a high prevalence of autoimmunity. Immunologic abnormalities have been described since many years in this population, both from a numerical and a functional points of view, and these abnormalities can mirror the ones observed during normal aging. In this review, we summarize our knowledge on immunologic disturbances commonly observed in subjects with Down syndrome, and in innate and adaptive immunity, as well as regarding chronic inflammation. We then discuss the role of accelerated aging in these observed abnormalities and finally review the potential age-associated molecular and cellular mechanisms involved.

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)

Hitta via bibliotek

Till lärosätets databas

Hitta mer i SwePub

Av författaren/redakt...
Gensous, N
Bacalini, MG
Franceschi, C
Garagnani, P
Artiklar i publikationen
Seminars in immu ...
Av lärosätet
Karolinska Institutet

Sök utanför SwePub

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy