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- Ramilowski, JA (author)
Functional annotation of human long noncoding RNAs via molecular phenotyping
- Article/chapterEnglish2020
Publisher, publication year, extent ...
- 2020-07-27
- Cold Spring Harbor Laboratory,2020
Numbers
- LIBRIS-ID:oai:prod.swepub.kib.ki.se:144290843
- http://kipublications.ki.se/Default.aspx?queryparsed=id:144290843URI
- https://doi.org/10.1101/gr.254219.119DOI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
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Notes
- Long noncoding RNAs (lncRNAs) constitute the majority of transcripts in the mammalian genomes, and yet, their functions remain largely unknown. As part of the FANTOM6 project, we systematically knocked down the expression of 285 lncRNAs in human dermal fibroblasts and quantified cellular growth, morphological changes, and transcriptomic responses using Capped Analysis of Gene Expression (CAGE). Antisense oligonucleotides targeting the same lncRNAs exhibited global concordance, and the molecular phenotype, measured by CAGE, recapitulated the observed cellular phenotypes while providing additional insights on the affected genes and pathways. Here, we disseminate the largest-to-date lncRNA knockdown data set with molecular phenotyping (over 1000 CAGE deep-sequencing libraries) for further exploration and highlight functional roles for ZNF213-AS1 and lnc-KHDC3L-2.
Added entries (persons, corporate bodies, meetings, titles ...)
- Yip, CW (author)
- Agrawal, S (author)
- Chang, JC (author)
- Ciani, Y (author)
- Kulakovskiy, IV (author)
- Mendez, M (author)
- Ooi, JL (author)
- Ouyang, JF (author)
- Parkinson, N (author)
- Petri, A (author)
- Roos, L (author)
- Severin, J (author)
- Yasuzawa, K (author)
- Abugessaisa, I (author)
- Akalin, A (author)
- Antonov, IV (author)
- Arner, E (author)
- Bonetti, A (author)
- Bono, H (author)
- Borsari, B (author)
- Brombacher, F (author)
- Cameron, CJF (author)
- Cannistraci, CV (author)
- Cardenas, R (author)
- Cardon, M (author)
- Chang, HW (author)
- Dostie, J (author)
- Ducoli, L (author)
- Favorov, A (author)
- Fort, A (author)
- Garrido, D (author)
- Gil, N (author)
- Gimenez, J (author)
- Guler, R (author)
- Handoko, L (author)
- Harshbarger, J (author)
- Hasegawa, A (author)
- Hasegawa, Y (author)
- Hashimoto, K (author)
- Hayatsu, N (author)
- Heutink, P (author)
- Hirose, T (author)
- Imada, EL (author)
- Itoh, M (author)
- Kaczkowski, B (author)
- Kanhere, A (author)
- Kawabata, E (author)
- Kawaji, H (author)
- Kawashima, T (author)
- Kelly, ST (author)
- Kojima, M (author)
- Kondo, N (author)
- Koseki, H (author)
- Kouno, T (author)
- Kratz, A (author)
- Kurowska-Stolarska, M (author)
- Kwon, ATJ (author)
- Leek, J (author)
- Lennartsson, AKarolinska Institutet (author)
- Lizio, M (author)
- Lopez-Redondo, F (author)
- Luginbuhl, J (author)
- Maeda, S (author)
- Makeev, VJ (author)
- Marchionni, L (author)
- Medvedeva, YA (author)
- Minoda, A (author)
- Muller, F (author)
- Munoz-Aguirre, M (author)
- Murata, M (author)
- Nishiyori, H (author)
- Nitta, KR (author)
- Noguchi, S (author)
- Noro, Y (author)
- Nurtdinov, R (author)
- Okazaki, Y (author)
- Orlando, V (author)
- Paquette, D (author)
- Parr, CJC (author)
- Rackham, OJL (author)
- Rizzu, P (author)
- Martinez, DFS (author)
- Sandelin, A (author)
- Sanjana, P (author)
- Semple, CAM (author)
- Shibayama, Y (author)
- Sivaraman, DM (author)
- Suzuki, T (author)
- Szumowski, SC (author)
- Tagami, M (author)
- Taylor, MS (author)
- Terao, C (author)
- Thodberg, M (author)
- Thongjuea, S (author)
- Tripathi, V (author)
- Ulitsky, I (author)
- Verardo, R (author)
- Vorontsov, IE (author)
- Yamamoto, C (author)
- Young, RS (author)
- Baillie, JK (author)
- Forrest, ARR (author)
- Guigo, R (author)
- Hoffman, MM (author)
- Hon, CC (author)
- Kasukawa, T (author)
- Kauppinen, S (author)
- Kere, JKarolinska Institutet (author)
- Lenhard, B (author)
- Schneider, C (author)
- Suzuki, H (author)
- Yagi, K (author)
- de Hoon, MJL (author)
- Shin, JW (author)
- Carninci, P (author)
- Karolinska Institutet (creator_code:org_t)
Related titles
- In:Genome research: Cold Spring Harbor Laboratory30:7, s. 1060-10721549-54691088-9051
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- By the author/editor
- Ramilowski, JA
- Yip, CW
- Agrawal, S
- Chang, JC
- Ciani, Y
- Kulakovskiy, IV
- show more...
- Mendez, M
- Ooi, JL
- Ouyang, JF
- Parkinson, N
- Petri, A
- Roos, L
- Severin, J
- Yasuzawa, K
- Abugessaisa, I
- Akalin, A
- Antonov, IV
- Arner, E
- Bonetti, A
- Bono, H
- Borsari, B
- Brombacher, F
- Cameron, CJF
- Cannistraci, CV
- Cardenas, R
- Cardon, M
- Chang, HW
- Dostie, J
- Ducoli, L
- Favorov, A
- Fort, A
- Garrido, D
- Gil, N
- Gimenez, J
- Guler, R
- Handoko, L
- Harshbarger, J
- Hasegawa, A
- Hasegawa, Y
- Hashimoto, K
- Hayatsu, N
- Heutink, P
- Hirose, T
- Imada, EL
- Itoh, M
- Kaczkowski, B
- Kanhere, A
- Kawabata, E
- Kawaji, H
- Kawashima, T
- Kelly, ST
- Kojima, M
- Kondo, N
- Koseki, H
- Kouno, T
- Kratz, A
- Kurowska-Stolars ...
- Kwon, ATJ
- Leek, J
- Lennartsson, A
- Lizio, M
- Lopez-Redondo, F
- Luginbuhl, J
- Maeda, S
- Makeev, VJ
- Marchionni, L
- Medvedeva, YA
- Minoda, A
- Muller, F
- Munoz-Aguirre, M
- Murata, M
- Nishiyori, H
- Nitta, KR
- Noguchi, S
- Noro, Y
- Nurtdinov, R
- Okazaki, Y
- Orlando, V
- Paquette, D
- Parr, CJC
- Rackham, OJL
- Rizzu, P
- Martinez, DFS
- Sandelin, A
- Sanjana, P
- Semple, CAM
- Shibayama, Y
- Sivaraman, DM
- Suzuki, T
- Szumowski, SC
- Tagami, M
- Taylor, MS
- Terao, C
- Thodberg, M
- Thongjuea, S
- Tripathi, V
- Ulitsky, I
- Verardo, R
- Vorontsov, IE
- Yamamoto, C
- Young, RS
- Baillie, JK
- Forrest, ARR
- Guigo, R
- Hoffman, MM
- Hon, CC
- Kasukawa, T
- Kauppinen, S
- Kere, J
- Lenhard, B
- Schneider, C
- Suzuki, H
- Yagi, K
- de Hoon, MJL
- Shin, JW
- Carninci, P
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