WFRF:(Persson T.)
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- Elvsashagen, T (author)
The genetic architecture of human brainstem structures and their involvement in common brain disorders
- Article/chapterEnglish2020
Publisher, publication year, extent ...
- 2020-08-11
- Springer Science and Business Media LLC,2020
Numbers
- LIBRIS-ID:oai:prod.swepub.kib.ki.se:144486580
- http://kipublications.ki.se/Default.aspx?queryparsed=id:144486580URI
- https://doi.org/10.1038/s41467-020-17376-1DOI
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-174902URI
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-440787URI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- Brainstem regions support vital bodily functions, yet their genetic architectures and involvement in common brain disorders remain understudied. Here, using imaging-genetics data from a discovery sample of 27,034 individuals, we identify 45 brainstem-associated genetic loci, including the first linked to midbrain, pons, and medulla oblongata volumes, and map them to 305 genes. In a replication sample of 7432 participants most of the loci show the same effect direction and are significant at a nominal threshold. We detect genetic overlap between brainstem volumes and eight psychiatric and neurological disorders. In additional clinical data from 5062 individuals with common brain disorders and 11,257 healthy controls, we observe differential volume alterations in schizophrenia, bipolar disorder, multiple sclerosis, mild cognitive impairment, dementia, and Parkinson’s disease, supporting the relevance of brainstem regions and their genetic architectures in common brain disorders.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Neurovetenskaper hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Neurosciences hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Psykiatri hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Psychiatry hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Radiologi och bildbehandling hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Radiology, Nuclear Medicine and Medical Imaging hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Neurologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Neurology hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Medicinsk genetik hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Medical Genetics hsv//eng
Added entries (persons, corporate bodies, meetings, titles ...)
- Bahrami, S (author)
- van der Meer, D (author)
- Agartz, IKarolinska Institutet (author)
- Alnaes, D (author)
- Barch, DM (author)
- Baur-Streubel, R (author)
- Bertolino, A (author)
- Beyer, MK (author)
- Blasi, G (author)
- Borgwardt, S (author)
- Boye, B (author)
- Buitelaar, J (author)
- Boen, E (author)
- Celius, EGKarolinska Institutet (author)
- Cervenka, SimonKarolinska Institutet,Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Stockholm Region, Stockholm, Sweden(Swepub:uu)simce160 (author)
- Conzelmann, A (author)
- Coynel, D (author)
- Di Carlo, P (author)
- Djurovic, S (author)
- Eisenacher, S (author)
- Espeseth, T (author)
- Fatouros-Bergman, HKarolinska Institutet (author)
- Flyckt, LKarolinska Institutet (author)
- Franke, B (author)
- Frei, OKarolinska Institutet (author)
- Gelao, B (author)
- Harbo, HF (author)
- Hartman, CA (author)
- Haberg, A (author)
- Heslenfeld, D (author)
- Hoekstra, PJ (author)
- Hogestol, EA (author)
- Jonassen, R (author)
- Jonsson, EGKarolinska Institutet (author)
- Kirsch, P (author)
- Kloszewska, I (author)
- Lagerberg, TV (author)
- Landro, NI (author)
- Le Hellard, SKarolinska Institutet (author)
- Lesch, KP (author)
- Maglanoc, LA (author)
- Malt, UF (author)
- Mecocci, P (author)
- Melle, I (author)
- Meyer-Lindenberg, A (author)
- Moberget, T (author)
- Nordvik, JE (author)
- Nyberg, Lars,1966-Umeå universitet,Diagnostisk radiologi,Institutionen för integrativ medicinsk biologi (IMB),Umeå centrum för funktionell hjärnavbildning (UFBI)(Swepub:umu)lany0001 (author)
- O'Connell, KS (author)
- Oosterlaan, J (author)
- Papalino, M (author)
- Papassotiropoulos, A (author)
- Pauli, P (author)
- Pergola, G (author)
- Persson, K (author)
- de Quervain, D (author)
- Reif, A (author)
- Rokicki, J (author)
- van Rooij, D (author)
- Shadrin, AA (author)
- Schmidt, A (author)
- Schwarz, E (author)
- Selbaek, G (author)
- Soininen, H (author)
- Sowa, P (author)
- Steen, VM (author)
- Tsolaki, M (author)
- Vellas, B (author)
- Wang, L (author)
- Westman, EKarolinska Institutet (author)
- Ziegler, GC (author)
- Zink, M (author)
- Andreassen, OA (author)
- Westlye, LT (author)
- Kaufmann, T (author)
- Farde, LKarolinska Institutet (author)
- Flyckt, LKarolinska Institutet (author)
- Engberg, GKarolinska Institutet (author)
- Erhardt, SS (author)
- Fatouros-Bergman, HKarolinska Institutet (author)
- Cervenka, SKarolinska Institutet (author)
- Schwieler, LKarolinska Institutet (author)
- Piehl, FKarolinska Institutet (author)
- Agartz, IKarolinska Institutet (author)
- Collste, K (author)
- Victorsson, P (author)
- Malmqvist, AKarolinska Institutet (author)
- Hedberg, M (author)
- Orhan, FKarolinska Institutet (author)
- Sellgren, CMKarolinska Institutet (author)
- Karolinska InstitutetCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Stockholm Region, Stockholm, Sweden (creator_code:org_t)
Related titles
- In:Nature communications: Springer Science and Business Media LLC11:1, s. 4016-2041-1723
Internet link
- https://www.nature.com/articles/s41467-020-17376-1.pdf
- https://doi.org/10.1038/s41467-020-17376-1Fulltext
- https://umu.diva-portal.org/smash/get/diva2:1466941/FULLTEXT01.pdffulltext:print
- https://uu.diva-portal.org/smash/get/diva2:1545984/FULLTEXT01.pdffulltext:print
- http://kipublications.ki.se/Default.aspx?queryparsed=id:144486580
- https://doi.org/10.1038/s41467-020-17376-1
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-174902
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-440787
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- Elvsashagen, T
- Bahrami, S
- van der Meer, D
- Agartz, I
- Alnaes, D
- Barch, DM
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- Baur-Streubel, R
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- Jonassen, R
- Jonsson, EG
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- Kloszewska, I
- Lagerberg, TV
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- Le Hellard, S
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