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Repositioning of th...
Repositioning of the global epicentre of non-optimal cholesterol
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- Taddei, C (author)
- Imperial College London, United Kingdom,Imperial Coll London, London, England
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Zhou, B (author)
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Bixby, H (author)
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Carrillo-Larco, RM (author)
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Danaei, G (author)
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Jackson, R (author)
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Farzadfar, F (author)
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Sophiea, MK (author)
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Di Cesare, M (author)
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- Lind, Lars (author)
- Uppsala universitet,Klinisk epidemiologi
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- Rosengren, Annika, 1951 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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Asghari, G (author)
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Dhana, K (author)
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Gulayin, P (author)
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Kakarmath, S (author)
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Santero, M (author)
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Voortman, T (author)
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Riley, LM (author)
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Cowan, MJ (author)
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Savin, S (author)
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Bennett, JE (author)
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- Giwercman, Aleksander (author)
- Lund University,Lunds universitet,Reproduktionsmedicin, Malmö,Forskargrupper vid Lunds universitet,Reproductive medicine, Malmö,Lund University Research Groups
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Paciorek, CJ (author)
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Aekplakorn, W (author)
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Cifkova, R (author)
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Giampaoli, S (author)
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Kengne, AP (author)
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Khang, YH (author)
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Kuulasmaa, K (author)
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Laxmaiah, A (author)
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Margozzini, P (author)
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Mathur, P (author)
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Nordestgaard, BG (author)
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Zhao, D (author)
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Aadahl, M (author)
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Abarca-Gomez, L (author)
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Rahim, HA (author)
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Abu-Rmeileh, NM (author)
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Acosta-Cazares, B (author)
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Adams, RJ (author)
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Agdeppa, IA (author)
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Aghazadeh-Attari, J (author)
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Aguilar-Salinas, CA (author)
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Agyemang, C (author)
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- Söderberg, Stefan (author)
- Umeå universitet,Avdelningen för medicin
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Ahmad, NA (author)
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Ahmadi, A (author)
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Ahmadi, N (author)
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Ahmed, SH (author)
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Ahrens, W (author)
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Ajlouni, K (author)
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Alarouj, M (author)
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AlBuhairan, F (author)
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AlDhukair, S (author)
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Ali, MM (author)
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Alkandari, A (author)
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Alkerwi, A (author)
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Aly, E (author)
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Amarapurkar, DN (author)
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Amouyel, P (author)
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Andersen, LB (author)
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Anderssen, SA (author)
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Anjana, RM (author)
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Ansari-Moghaddam, A (author)
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Aounallah-Skhiri, H (author)
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Araujo, J (author)
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Ariansen, I (author)
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Aris, T (author)
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- Eggertsen, Robert, 1948 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine
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Arlappa, N (author)
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Aryal, KK (author)
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Aspelund, T (author)
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- Forsner, Maria, 1954- (author)
- Karolinska Institutet,Umeå universitet,Institutionen för omvårdnad
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Auvinen, J (author)
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Avdicova, M (author)
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Azevedo, A (author)
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Azizi, F (author)
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Balakrishna, N (author)
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Banach, M (author)
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Bandosz, P (author)
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Banegas, JR (author)
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Batieha, AM (author)
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Beaglehole, R (author)
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Ben Romdhane, H (author)
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Benet, M (author)
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Blokstra, A (author)
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Bo, S (author)
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Boggia, JG (author)
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Boissonnet, CP (author)
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Busch, MA (author)
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de Leon, AC (author)
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Cacciottolo, J (author)
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D'Arrigo, G (author)
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d'Orsi, E (author)
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Dallongeville, J (author)
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Damasceno, A (author)
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Dankner, R (author)
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Dantoft, TM (author)
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Dauchet, L (author)
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Davletov, K (author)
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de Gaetano, G (author)
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De Henauw, S (author)
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de Oliveira, PD (author)
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Deepa, M (author)
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Di Castelnuovo, AF (author)
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Dzerve, V (author)
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Dziankowska-Zaborszczyk, E (author)
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Eddie, R (author)
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Eftekhar, E (author)
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Eggertsen, R (author)
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Eghtesad, S (author)
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- Eiben, Gabriele (author)
- Högskolan i Skövde,Institutionen för hälsovetenskaper,Forskningsmiljön hälsa, hållbarhet och digitalisering,Individ och samhälle VIDSOC, Individual and Society
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Ekelund, U (author)
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El Ati, J (author)
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Eldemire-Shearer, D (author)
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Eliasen, M (author)
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Elosua, R (author)
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Eriksson, JG (author)
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Escobedo-de la Pena, J (author)
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Esmaeili, A (author)
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Faeh, D (author)
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Faramarzi, E (author)
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Fattahi, MR (author)
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Felix-Redondo, FJ (author)
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Ferguson, TS (author)
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Fernandez-Berges, D (author)
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Ferrari, M (author)
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Ferreccio, C (author)
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Ferrieres, J (author)
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Foger, B (author)
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Foo, LH (author)
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- Forslund, Ann-Sofie (author)
- Umeå universitet,Institutionen för folkhälsa och klinisk medicin
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- Forsner, M (author)
- Karolinska Institutet
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Fouad, HM (author)
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Francis, DK (author)
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Franco, MD (author)
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Franco, OH (author)
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Frontera, G (author)
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Gasull, M (author)
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Gonzalez-Gross, M (author)
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Gonzalez-Rivas, JP (author)
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Gonzalez-Villalpando, C (author)
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- Gonzalez-Villalpando, ME (author)
- Imperial College London, United Kingdom / University of Ghana, Accra, Ghana,Imperial Coll London, London, England;Univ Ghana, Accra, Ghana
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Gonzalez, AR (author)
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Gottrand, F (author)
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Graff-Iversen, S (author)
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Gregor, RD (author)
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Guan, OP (author)
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Gudnason, V (author)
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Hambleton, IR (author)
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Hamzeh, B (author)
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Hantunen, S (author)
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Kumar, RH (author)
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- Hashemi-Shahri, SM (author)
- Karolinska Institutet
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Hata, J (author)
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Haugsgjerd, T (author)
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Hayes, AJ (author)
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He, J (author)
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He, Y (author)
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Iannone, AG (author)
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Wong, NI (author)
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- Iglesia, I (author)
- Karolinska Institutet
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Ikeda, N (author)
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Ikram, MA (author)
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Iotova, V (author)
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Irazola, VE (author)
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Ishida, T (author)
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Jafar, T (author)
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James, K (author)
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Jamrozik, K (author)
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- Janszky, I (author)
- Karolinska Institutet
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Janus, E (author)
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Jarvelin, MR (author)
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Jasienska, G (author)
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Jelakovic, A (author)
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Kalter-Leibovici, O (author)
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Lin, X (author)
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- Yi-Ting, Lin (author)
- Uppsala universitet,Klinisk epidemiologi
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Lind, L (author)
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Linneberg, A (author)
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(creator_code:org_t)
- 2020-06-03
- 2020
- English.
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In: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 582:7810, s. 73-
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Abstract
Subject headings
Close
- High blood cholesterol is typically considered a feature of wealthy western countries1,2. However, dietary and behavioural determinants of blood cholesterol are changing rapidly throughout the world3 and countries are using lipid-lowering medications at varying rates. These changes can have distinct effects on the levels of high-density lipoprotein (HDL) cholesterol and non-HDL cholesterol, which have different effects on human health4,5. However, the trends of HDL and non-HDL cholesterol levels over time have not been previously reported in a global analysis. Here we pooled 1,127 population-based studies that measured blood lipids in 102.6 million individuals aged 18 years and older to estimate trends from 1980 to 2018 in mean total, non-HDL and HDL cholesterol levels for 200 countries. Globally, there was little change in total or non-HDL cholesterol from 1980 to 2018. This was a net effect of increases in low- and middle-income countries, especially in east and southeast Asia, and decreases in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe. As a result, countries with the highest level of non-HDL cholesterol—which is a marker of cardiovascular risk—changed from those in western Europe such as Belgium, Finland, Greenland, Iceland, Norway, Sweden, Switzerland and Malta in 1980 to those in Asia and the Pacific, such as Tokelau, Malaysia, The Philippines and Thailand. In 2017, high non-HDL cholesterol was responsible for an estimated 3.9 million (95% credible interval 3.7 million–4.2 million) worldwide deaths, half of which occurred in east, southeast and south Asia. The global repositioning of lipid-related risk, with non-optimal cholesterol shifting from a distinct feature of high-income countries in northwestern Europe, north America and Australasia to one that affects countries in east and southeast Asia and Oceania should motivate the use of population-based policies and personal interventions to improve nutrition and enhance access to treatment throughout the world.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Omvårdnad (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nursing (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Allmänmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- General Practice (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- Individual and Society VIDSOC
- high density lipoprotein cholesterol
- blood
- chemical compound
- lipid
- nutrition
- protein
- public health
- adult
- age distribution
- Article
- Australia and New Zealand
- brain ischemia
- cardiovascular mortality
- cardiovascular risk
- cholesterol blood level
- controlled study
- disease burden
- Europe
- female
- geographic distribution
- high income country
- human
- lipid analysis
- lipid blood level
- low income country
- male
- middle income country
- mortality rate
- North America
- population research
- priority journal
- sex ratio
- Southeast Asia
- trend study
- young adult
- Arctic
- Australasia
- Greenland
- Adolescent
- Adult
- Aged
- 80 and over
- Bayes Theorem
- Cholesterol
- HDL
- LDL
- Female
- Humans
- Hypercholesterolemia
- epidemiology
- Internationality
- Male
- Middle Aged
- Myocardial Ischemia
- Stroke
- Triglycerides
- Young Adult
Publication and Content Type
- ref (subject category)
- art (subject category)
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