Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: WFRF:(Shooter S) > Genetic predisposit...

1 of 4
Previous record
Next record
To hitlist

Details
MARC

Steinthorsdottir, VdeCODE Genetics (author)

Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women

Article/chapterEnglish2020

Publisher, publication year, extent ...

2020-11-25
Springer Science and Business Media LLC,2020

Numbers

LIBRIS-ID:oai:prod.swepub.kib.ki.se:145313049
http://kipublications.ki.se/Default.aspx?queryparsed=id:145313049URI
https://doi.org/10.1038/s41467-020-19733-6DOI
https://lup.lub.lu.se/record/a6b6540a-6095-432b-9f52-8ae1ba020ef3URI

Supplementary language notes

Language:English
Summary in:English

Part of subdatabase

SwePubSwePub

Classification

Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Preeclampsia is a serious complication of pregnancy, affecting both maternal and fetal health. In genome-wide association meta-analysis of European and Central Asian mothers, we identify sequence variants that associate with preeclampsia in the maternal genome at ZNF831/20q13 and FTO/16q12. These are previously established variants for blood pressure (BP) and the FTO variant has also been associated with body mass index (BMI). Further analysis of BP variants establishes that variants at MECOM/3q26, FGF5/4q21 and SH2B3/12q24 also associate with preeclampsia through the maternal genome. We further show that a polygenic risk score for hypertension associates with preeclampsia. However, comparison with gestational hypertension indicates that additional factors modify the risk of preeclampsia.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Reproduktionsmedicin och gynekologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Obstetrics, Gynaecology and Reproductive Medicine hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Medicinsk genetik hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Medical Genetics hsv//eng
blood
body mass
genome
meta-analysis
public health
risk assessment

Added entries (persons, corporate bodies, meetings, titles ...)

McGinnis, R (author)
Williams, NO (author)
Stefansdottir, L (author)
Thorleifsson, G (author)
Shooter, SKarolinska Institutet (author)
Fadista, JoaoLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Danish Serum Institute, Copenhagen(Swepub:lu)med-jft (author)
Sigurdsson, JKKarolinska Institutet (author)
Auro, KM (author)
Berezina, G (author)
Borges, MC (author)
Bumpstead, S (author)
Bybjerg-Grauholm, J (author)
Colgiu, I (author)
Dolby, VA (author)
Dudbridge, F (author)
Engel, SM (author)
Franklin, CS (author)
Frigge, MLUniversity of Nottingham (author)
Frisbaek, Y (author)
Geirsson, RT (author)
Geller, F (author)
Gretarsdottir, S (author)
Gudbjartsson, DF (author)
Harmon, Q (author)
Hougaard, DM (author)
Hegay, T (author)
Helgadottir, A (author)
Hjartardottir, S (author)
Jaaskelainen, T (author)
Johannsdottir, H (author)
Jonsdottir, I (author)
Juliusdottir, T (author)
Kalsheker, N (author)
Kasimov, A (author)
Kemp, JP (author)
Kivinen, K (author)
Klungsoyr, K (author)
Lee, WK (author)
Melbye, M (author)
Miedzybrodska, Z (author)
Moffett, A (author)
Najmutdinova, D (author)
Nishanova, F (author)
Olafsdottir, T (author)
Perola, M (author)
Pipkin, FB (author)
Poston, L (author)
Prescott, G (author)
Saevarsdottir, SKarolinska Institutet (author)
Salimbayeva, D (author)
Scaife, PJ (author)
Skotte, L (author)
Staines-Urias, E (author)
Stefansson, OA (author)
Sorensen, KM (author)
Thomsen, LCV (author)
Tragante, V (author)
Trogstad, L (author)
Simpson, NAB (author)
Laivuori, H (author)
Morgan, L (author)
Aripova, T (author)
Casas, JP (author)
Dominiczak, AF (author)
Walker, JJ (author)
Thorsteinsdottir, U (author)
Iversen, AC (author)
Feenstra, B (author)
Lawlor, DA (author)
Boyd, HA (author)
Magnus, P (author)
Laivuori, H (author)
Zakhidova, N (author)
Svyatova, G (author)
Stefansson, K (author)
Morgan, L (author)
Laivuori, H (author)
Heinonen, S (author)
Kajantie, E (author)
Kere, JKarolinska Institutet (author)
Kivinen, K (author)
Pouta, A (author)
Morgan, L (author)
Pipkin, FB (author)
Kalsheker, N (author)
Walker, JJ (author)
Macphail, S (author)
Kilby, M (author)
Habiba, M (author)
Williamson, C (author)
O'Shaughnessy, K (author)
O'Brien, S (author)
Cameron, A (author)
Redman, CWG (author)
Farrall, M (author)
Caulfield, M (author)
Dominiczak, AF (author)
Karolinska InstitutetdeCODE Genetics (creator_code:org_t)

Related titles

In:Nature communications: Springer Science and Business Media LLC11:1, s. 5976-2041-1723

Internet link

Find in a library

Nature communications (Search for host publication in LIBRIS)

To the university's database

1 of 4
Previous record
Next record
To hitlist

Find more in SwePub

By the author/editor: Steinthorsdottir ...; McGinnis, R; Williams, NO; Stefansdottir, L; Thorleifsson, G; Shooter, S; show more...; Fadista, Joao; Sigurdsson, JK; Auro, KM; Berezina, G; Borges, MC; Bumpstead, S; Bybjerg-Grauholm ...; Colgiu, I; Dolby, VA; Dudbridge, F; Engel, SM; Franklin, CS; Frigge, ML; Frisbaek, Y; Geirsson, RT; Geller, F; Gretarsdottir, S; Gudbjartsson, DF; Harmon, Q; Hougaard, DM; Hegay, T; Helgadottir, A; Hjartardottir, S; Jaaskelainen, T; Johannsdottir, H; Jonsdottir, I; Juliusdottir, T; Kalsheker, N; Kasimov, A; Kemp, JP; Kivinen, K; Klungsoyr, K; Lee, WK; Melbye, M; Miedzybrodska, Z; Moffett, A; Najmutdinova, D; Nishanova, F; Olafsdottir, T; Perola, M; Pipkin, FB; Poston, L; Prescott, G; Saevarsdottir, S; Salimbayeva, D; Scaife, PJ; Skotte, L; Staines-Urias, E; Stefansson, OA; Sorensen, KM; Thomsen, LCV; Tragante, V; Trogstad, L; Simpson, NAB; Laivuori, H; Morgan, L; Aripova, T; Casas, JP; Dominiczak, AF; Walker, JJ; Thorsteinsdottir ...; Iversen, AC; Feenstra, B; Lawlor, DA; Boyd, HA; Magnus, P; Zakhidova, N; Svyatova, G; Stefansson, K; Heinonen, S; Kajantie, E; Kere, J; Pouta, A; Macphail, S; Kilby, M; Habiba, M; Williamson, C; O'Shaughnessy, K; O'Brien, S; Cameron, A; Redman, CWG; Farrall, M; Caulfield, M; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Obstetrics Gynae ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Medical Genetics

Articles in the publication: Nature communica ...

By the university: Karolinska Institutet; Lund University

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se