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  • Huang, DL (author)

Vaccine elicitation of HIV broadly neutralizing antibodies from engineered B cells

  • Article/chapterEnglish2020

Publisher, publication year, extent ...

  • 2020-11-17
  • Springer Science and Business Media LLC,2020

Numbers

  • LIBRIS-ID:oai:prod.swepub.kib.ki.se:145322354
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:145322354URI
  • https://doi.org/10.1038/s41467-020-19650-8DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • HIV broadly neutralizing antibodies (bnAbs) can suppress viremia and protect against HIV infection. However, their elicitation is made difficult by low frequencies of appropriate precursor B cell receptors and the complex maturation pathways required to generate bnAbs from these precursors. Antibody genes can be engineered into B cells for expression as both a functional antigen receptor on cell surfaces and as secreted antibody. Here, we show that HIV bnAb-engineered primary mouse B cells can be adoptively transferred and vaccinated in immunocompetent mice resulting in the expansion of durable bnAb memory and long-lived plasma cells. Somatic hypermutation after immunization indicates that engineered cells have the capacity to respond to an evolving pathogen. These results encourage further exploration of engineered B cell vaccines as a strategy for durable elicitation of HIV bnAbs to protect against infection and as a contributor to a functional HIV cure.

Added entries (persons, corporate bodies, meetings, titles ...)

  • Tran, JT (author)
  • Olson, A (author)
  • Vollbrecht, T (author)
  • Tenuta, M (author)
  • Guryleva, MVKarolinska Institutet (author)
  • Fuller, RP (author)
  • Schiffner, T (author)
  • Abadejos, JR (author)
  • Couvrette, L (author)
  • Blane, TR (author)
  • Saye, K (author)
  • Li, WJ (author)
  • Landais, E (author)
  • Gonzalez-Martin, A (author)
  • Schief, W (author)
  • Murrell, BKarolinska Institutet (author)
  • Burton, DR (author)
  • Nemazee, D (author)
  • Voss, JE (author)
  • Karolinska Institutet (creator_code:org_t)

Related titles

  • In:Nature communications: Springer Science and Business Media LLC11:1, s. 5850-2041-1723

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