id:"swepub:oai:prod.swepub.kib.ki.se:145483114"
Sökning: id:"swepub:oai:prod.swepub.kib.ki.se:145483114" > Arsenic Exposure an...
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
- De Loma, JKarolinska Institutet (författare)
Arsenic Exposure and Cancer-Related Proteins in Urine of Indigenous Bolivian Women
- Artikel/kapitelEngelska2020
Förlag, utgivningsår, omfång ...
- 2020-12-14
- Frontiers Media SA,2020
Nummerbeteckningar
- LIBRIS-ID:oai:prod.swepub.kib.ki.se:145483114
- http://kipublications.ki.se/Default.aspx?queryparsed=id:145483114URI
- https://doi.org/10.3389/fpubh.2020.605123DOI
Kompletterande språkuppgifter
- Språk:engelska
- Sammanfattning på:engelska
Ingår i deldatabas
- SwePubSwePub
Klassifikation
Anmärkningar
- Indigenous people living in the Bolivian Andes are exposed through their drinking water to inorganic arsenic, a potent carcinogen. However, the health consequences of arsenic exposure in this region are unknown. The aim of this study was to evaluate associations between arsenic exposure and changes in cancer-related proteins in indigenous women (n = 176) from communities around the Andean Lake Poopó, Bolivia. Arsenic exposure was assessed in whole blood (B-As) and urine (as the sum of arsenic metabolites, U-As) by inductively coupled plasma-mass spectrometry (ICP-MS). Cancer-related proteins (N = 92) were measured in urine using the proximity extension assay. The median B-As concentration was 2.1 (range 0.60–9.1) ng/g, and U-As concentration was 67 (12–399) μg/L. Using linear regression models adjusted for age, urinary osmolality, and urinary leukocytes, we identified associations between B-As and four putative cancer-related proteins: FASLG, SEZ6L, LYPD3, and TFPI2. Increasing B-As concentrations were associated with lower protein expression of SEZ6L, LYPD3, and TFPI2, and with higher expression of FASLG in urine (no association was statistically significant after correcting for multiple comparisons). The associations were similar across groups with different arsenic metabolism efficiency, a susceptibility factor for arsenic toxicity. In conclusion, arsenic exposure in this region was associated with changes in the expression of some cancer-related proteins in urine. Future research is warranted to understand if these proteins could serve as valid biomarkers for arsenic-related toxicity.
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Gliga, ARKarolinska Institutet (författare)
- Levi, MKarolinska Institutet (författare)
- Ascui, F (författare)
- Gardon, J (författare)
- Tirado, N (författare)
- Broberg, KKarolinska Institutet (författare)
- Karolinska Institutet (creator_code:org_t)
Sammanhörande titlar
- Ingår i:Frontiers in public health: Frontiers Media SA8, s. 605123-2296-2565
Internetlänk
Hitta via bibliotek
- Frontiers in public health (Sök värdpublikationen i LIBRIS)
Till lärosätets databas
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
Hitta mer i SwePub
- Av författaren/redakt...
- De Loma, J
- Gliga, AR
- Levi, M
- Ascui, F
- Gardon, J
- Tirado, N
- visa fler...
- Broberg, K
- visa färre...
- Artiklar i publikationen
- Frontiers in pub ...
- Av lärosätet
- Karolinska Institutet
Sök utanför SwePub
- Sök vidare i:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - Nationella bibliotekssystem
- LIBRIS.kb.se
