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Post-Transplant Cyc...
Post-Transplant Cyclophosphamide Combined with Anti-Thymocyte Globulin as Graft-versus-Host Disease Prophylaxis for Allogeneic Hematopoietic Cell Transplantation in High-Risk Acute Myeloid Leukemia and Myelodysplastic Syndrome
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Alanazi, W (author)
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Chen, SY (author)
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Lipton, JH (author)
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Kim, DD (author)
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Viswabandya, A (author)
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Kumar, R (author)
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Lam, W (author)
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Law, AD (author)
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Al-Shaibani, Z (author)
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- Mattsson, J (author)
- Karolinska Institutet
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Michelis, FV (author)
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(creator_code:org_t)
- 2020-05-19
- 2021
- English.
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In: Acta haematologica. - : S. Karger AG. - 1421-9662 .- 0001-5792. ; 144:1, s. 66-73
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https://www.karger.c...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
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- <b><i>Background:</i></b> Allogeneic hematopoietic cell transplantation (HCT) is curative for high-risk acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) but with significant non-relapse mortality (NRM) and relapse. We compared the combination of anti-thymocyte globulin (ATG; 4.5 mg/kg) and post-transplant cyclophosphamide (PTCy; 50 mg/kg on day +3 and +4) with other graft-versus-host disease (GvHD) prophylaxis regimens used for these patients. <b><i>Methods:</i></b> We retrospectively analyzed 159 patients, aged 22–73 (median 56) years, having undergone transplantation for high-risk AML (<i>n</i> = 120) or MDS (<i>n</i> = 39). The donors were matched related (33%), unrelated (55%) and haploidentical (12%). Almost all patients used peripheral blood stem cells. Conditioning was myeloablative (34%) or reduced intensity (66%). ATG + PTCy was used in 69 patients (43%), and other GvHD prophylaxis regimens in 90 patients (57%). <b><i>Results:</i></b> Grade III–IV acute GvHD occurred in 4% of the ATG + PTCy patients versus 20% of those using other regimens (<i>p</i> = 0.004), and chronic GvHD in 19% of the ATG + PTCy patients versus 41% of those using other regimens (<i>p</i> = 0.003). Two-year GvHD-free relapse-free survival (GRFS) was 30% with ATG + PTCy versus 18% with other regimens (<i>p</i> = 0.04). Multivariable analysis demonstrated that while ATG + PTCy had no significant influence on overall survival, cumulative incidence of relapse or NRM, there was a significant influence on GRFS in favor of ATG + PTCy (HR = 0.69, 95% CI 0.45–0.99, <i>p</i> = 0.04). <b><i>Conclusions:</i></b> We conclude that the ATG + PTCy combination significantly improved GRFS in allogeneic HCT for high-risk AML and MDS without influencing other outcomes.
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- By the author/editor
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Alanazi, W
-
Chen, SY
-
Lipton, JH
-
Kim, DD
-
Viswabandya, A
-
Kumar, R
-
show more...
-
Lam, W
-
Law, AD
-
Al-Shaibani, Z
-
Mattsson, J
-
Michelis, FV
-
show less...
- Articles in the publication
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Acta haematologi ...
- By the university
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Karolinska Institutet