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  • Bona, KHarvard Med Sch, Dana Farber Canc Inst, Dept Pediat Oncol, Div Populat Sci, Boston, MA 02115 USA. (author)

Neighborhood poverty and pediatric allogeneic hematopoietic cell transplantation outcomes: a CIBMTR analysis

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • American Society of Hematology,2021

Numbers

  • LIBRIS-ID:oai:prod.swepub.kib.ki.se:145978081
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:145978081URI
  • https://doi.org/10.1182/blood.2020006252DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-438030URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Social determinants of health, including poverty, contribute significantly to health outcomes in the United States; however, their impact on pediatric hematopoietic cell transplantation (HCT) outcomes is poorly understood. We aimed to identify the association between neighborhood poverty and HCT outcomes for pediatric allogeneic HCT recipients in the Center for International Blood and Marrow Transplant Research database. We assembled 2 pediatric cohorts undergoing first allogeneic HCT from 2006 to 2015 at age ≤18 years, including 2053 children with malignant disease and 1696 children with nonmalignant disease. Neighborhood poverty exposure was defined a priori per the US Census definition as living in a high-poverty ZIP code (≥20% of persons below 100% federal poverty level) and used as the primary predictor in all analyses. Our primary outcome was overall survival (OS), defined as the time from HCT until death resulting from any cause. Secondary outcomes included relapse and transplantation-related mortality (TRM) in malignant disease, acute and chronic graft-versus-host disease, and infection in the first 100 days post-HCT. Among children undergoing transplantation for nonmalignant disease, neighborhood poverty was not associated with any HCT outcome. Among children undergoing transplantation for malignant disease, neighborhood poverty conferred an increased risk of TRM but was not associated with inferior OS or any other transplantation outcome. Among children with malignant disease, a key secondary finding was that children with Medicaid insurance experienced inferior OS and increased TRM compared with those with private insurance. These data suggest opportunities for future investigation of the effects of household-level poverty exposure on HCT outcomes in pediatric malignant disease to inform care delivery interventions.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Brazauskas, RMed Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res CIBMTR, Inst Hlth & Equ, Milwaukee, WI 53226 USA.;Med Coll Wisconsin, Inst Hlth & Equ, Div Biostat, Milwaukee, WI 53226 USA. (author)
  • He, NYMed Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res CIBMTR, Inst Hlth & Equ, Milwaukee, WI 53226 USA. (author)
  • Lehmann, LHarvard Med Sch, Dana Farber Canc Inst, Dept Pediat Oncol, Boston Childrens Hosp, Boston, MA 02115 USA. (author)
  • Abdel-Azim, HUniv Southern Calif, Keck Sch Med, Childrens Hosp Los Angeles, Div Hematol Oncol & Blood & Marrow Transplantat, Los Angeles, CA 90007 USA.,New York Univ Langone Hlth, New York, NY USA.,TriStar Centennial, Childrens Hosp, Nashville, TN USA.;Sarah Cannon Res Inst, Nashville, TN USA. (author)
  • Ahmed, IAChildrens Mercy Hosp & Clin, Dept Hematol Oncol & Bone Marrow Transplantat, Kansas City, MO USA. (author)
  • Al-Homsi, ASDokkyo Med Univ, Dept Hematol & Oncol, Mibu, Tochigi, Japan.,St Jude Childrens Res Hosp, Dept Bone Marrow Transplantat & Cellular Therapy, 332 N Lauderdale St, Memphis, TN 38105 USA.,Christian Med Coll & Hosp, Ctr Stem Cell Res, Vellore, Tamil Nadu, India.,Mt Sinai Hosp, Div Hematol & Oncol, New York, NY 10029 USA. (author)
  • Aljurf, MKing Faisal Specialist Hosp Ctr & Res, Dept Oncol, Riyadh, Saudi Arabia. (author)
  • Arnold, SDEmory Univ, Childrens Healthcare Atlanta, Aflac Canc & Blood Disorder Ctr, Atlanta, GA 30322 USA.,Univ Manitoba, CancerCare Manitoba, Winnipeg, MB, Canada. (author)
  • Badawy, SMAnn & Robert H Lurie Childrens Hosp Chicago, Div Hematol Oncol & Stem Cell Transplant, Chicago, IL 60611 USA.;Northwestern Univ, Dept Pediat, Feinberg Sch Med, Chicago, IL 60611 USA. (author)
  • Battiwalla, MSarah Cannon Blood Canc Network, Nashville, TN USA. (author)
  • Beattie, STom Baker Canc Clin, Dept Psychosocial Oncol & Rehabil, Calgary, AB, Canada.;Univ Calgary, Dept Oncol, Calgary, AB, Canada. (author)
  • Bhatt, NSFred Hutchinson Canc Res Ctr, 1124 Columbia St, Seattle, WA 98104 USA. (author)
  • Dalal, JCleveland Case Western Reserve Sch Med, Rainbow Babies & Childrens Hosp, Cleveland, OH USA. (author)
  • Dandoy, CEUniv Cincinnati, Sch Med, Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH USA. (author)
  • Diaz, MAHosp Infantil Univ Nino Jesus, Dept Hematol Oncol, Madrid, Spain. (author)
  • Frangoul, HA (author)
  • Freytes, COTexas Transplant Inst, San Antonio, TX USA. (author)
  • Ganguly, SUniv Kansas Hlth Syst, Div Hematol Malignancy & Cellular Therapeut, Kansas City, KS USA. (author)
  • George, BChristian Med Coll & Hosp, Dept Haematol, Vellore, Tamil Nadu, India. (author)
  • Gomez-Almaguer, DUniv Autonoma Nuevo, Hosp Univ Dr Jose E Gonzalez, Monterrey, Mexico. (author)
  • Hahn, TRoswell Park Comprehens Canc Ctr, Dept Med, Buffalo, NY USA. (author)
  • Kamble, RTBaylor Coll Med, Ctr Cell & Gene Therapy, Div Hematol & Oncol, Houston, TX USA. (author)
  • Knight, JMMed Coll Wisconsin, Dept Psychiat, Milwaukee, WI 53226 USA. (author)
  • LeMaistre, CFSarah Cannon Blood Canc Network, Nashville, TN USA. (author)
  • Law, JTufts Med Ctr, Div Pediat Hematol Oncol, Floating Hosp Children, Boston, MA 02111 USA. (author)
  • Lazarus, HMCase Western Reserve Univ, Univ Hosp Cleveland Med Ctr, Cleveland, OH 44106 USA. (author)
  • Majhail, NSCleveland Clin, Blood & Marrow Transplant Program, Taussig Canc Inst, Cleveland, OH 44106 USA. (author)
  • Olsson, RFUppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD),Karolinska Inst, Dept Lab Med, Stockholm, Sweden. (author)
  • Preussler, JNatl Marrow Donor Program Be Match, CIBMTR, Minneapolis, MN USA. (author)
  • Savani, BNVanderbilt Univ, Med Ctr, Dept Med, Div Hematol Oncol, Nashville, TN USA. (author)
  • Schears, RUniv Cent Florida, Dept Emergency Med, Orlando, FL 32816 USA. (author)
  • Seo, S (author)
  • Sharma, A (author)
  • Srivastava, A (author)
  • Steinberg, A (author)
  • Szwajcer, D (author)
  • Wirk, BPenn State Canc Inst, Bone Marrow Transplant Program, Hershey, PA USA. (author)
  • Yoshimi, AUniv Freiburg, Med Ctr, Dept Pediat & Adolescent Med, Div Pediat Hematol & Oncol, Freiburg, Germany. (author)
  • Khera, NMayo Clin, Dept Hematol Oncol, Phoenix, AZ USA. (author)
  • Wood, WAUniv N Carolina, Dept Med, Div Hematol Oncol, Chapel Hill, NC USA. (author)
  • Hashmi, SMayo Clin, Dept Internal Med, Minneapolis, MN USA.;King Faisal Specialist Hosp & Res Ctr, Oncol Ctr, Riyadh, Saudi Arabia. (author)
  • Duncan, CNHarvard Med Sch, Dana Farber Canc Inst, Dept Pediat Oncol, Boston Childrens Hosp, Boston, MA 02115 USA. (author)
  • Saber, WMed Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res CIBMTR, Inst Hlth & Equ, Milwaukee, WI 53226 USA. (author)
  • Harvard Med Sch, Dana Farber Canc Inst, Dept Pediat Oncol, Div Populat Sci, Boston, MA 02115 USA.Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res CIBMTR, Inst Hlth & Equ, Milwaukee, WI 53226 USA.;Med Coll Wisconsin, Inst Hlth & Equ, Div Biostat, Milwaukee, WI 53226 USA. (creator_code:org_t)

Related titles

  • In:Blood: American Society of Hematology137:4, s. 556-5681528-00200006-4971

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