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Salivary Biomarkers...
Salivary Biomarkers for Dental Caries Detection and Personalized Monitoring
- Artikel/kapitelEngelska2021
Förlag, utgivningsår, omfång ...
Nummerbeteckningar
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:146285273
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http://kipublications.ki.se/Default.aspx?queryparsed=id:146285273URI
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https://doi.org/10.3390/jpm11030235DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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This study investigated the potential of salivary bacterial and protein markers for evaluating the disease status in healthy individuals or patients with gingivitis or caries. Saliva samples from caries- and gingivitis-free individuals (n = 18), patients with gingivitis (n = 17), or patients with deep caries lesions (n = 38) were collected and analyzed for 44 candidate biomarkers (cytokines, chemokines, growth factors, matrix metalloproteinases, a metallopeptidase inhibitor, proteolytic enzymes, and selected oral bacteria). The resulting data were subjected to principal component analysis and used as a training set for random forest (RF) modeling. This computational analysis revealed four biomarkers (IL-4, IL-13, IL-2-RA, and eotaxin/CCL11) to be of high importance for the correct depiction of caries in 37 of 38 patients. The RF model was then used to classify 10 subjects (five caries-/gingivitis-free and five with caries), who were followed over a period of six months. The results were compared to the clinical assessments of dental specialists, revealing a high correlation between the RF prediction and the clinical classification. Due to the superior sensitivity of the RF model, there was a divergence in the prediction of two caries and four caries-/gingivitis-free subjects. These findings suggest IL-4, IL-13, IL-2-RA, and eotaxin/CCL11 as potential salivary biomarkers for identifying noninvasive caries. Furthermore, we suggest a potential association between JAK/STAT signaling and dental caries onset and progression.
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Herz, C
(författare)
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Wiedemeier, DB
(författare)
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Mitsakakis, K
(författare)
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Attin, T
(författare)
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Bao, KKarolinska Institutet
(författare)
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Belibasakis, GNKarolinska Institutet
(författare)
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Hays, JP
(författare)
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Jenzer, JS
(författare)
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Kaman, WE
(författare)
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Karpisek, M
(författare)
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Korner, P
(författare)
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Peham, JR
(författare)
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Schmidlin, PR
(författare)
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Thurnheer, T
(författare)
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Wegehaupt, FJ
(författare)
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Bostanci, NKarolinska Institutet
(författare)
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Karolinska Institutet
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of personalized medicine: MDPI AG11:32075-4426
Internetlänk
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Till lärosätets databas
- Av författaren/redakt...
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Paque, PN
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Herz, C
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Wiedemeier, DB
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Mitsakakis, K
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Attin, T
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Bao, K
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visa fler...
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Belibasakis, GN
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Hays, JP
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Jenzer, JS
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Kaman, WE
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Karpisek, M
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Korner, P
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Peham, JR
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Schmidlin, PR
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Thurnheer, T
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Wegehaupt, FJ
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Bostanci, N
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visa färre...
- Artiklar i publikationen
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Journal of perso ...
- Av lärosätet
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Karolinska Institutet