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- Bergstrom, A (author)
Severe liver disease resembling PSC in mice with K5-Cre mediated deletion of Krüppel-like factor 5 (Klf5)
- Article/chapterEnglish2021
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- 2021-06-11
- Springer Science and Business Media LLC,2021
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- LIBRIS-ID:oai:prod.swepub.kib.ki.se:146849649
- http://kipublications.ki.se/Default.aspx?queryparsed=id:146849649URI
- https://doi.org/10.1007/s11248-021-00267-6DOI
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- Language:English
- Summary in:English
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- Chronic cholestatic liver diseases including primary sclerosing cholangitis (PSC) present a complex spectrum with regards to the cause, age of manifestation and histopathological features. Current treatment options are severely limited primarily due to a paucity of model systems mirroring the disease. Here, we describe the Keratin 5 (K5)-Cre; Klf5fl/fl mouse that spontaneously develops severe liver disease during the postnatal period with features resembling PSC including a prominent ductular reaction, fibrotic obliteration of the bile ducts and secondary degeneration/necrosis of liver parenchyma. Over time, there is an expansion of Sox9+ hepatocytes in the damaged livers suggestive of a hepatocyte-mediated regenerative response. We conclude that Klf5 is required for the normal function of the hepatobiliary system and that the K5-Cre; Klf5fl/fl mouse is an excellent model to probe the molecular events interlinking damage and regenerative response in the liver.
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- Gerling, MKarolinska Institutet (author)
- Van Hul, NKarolinska Institutet (author)
- Moro, CFKarolinska Institutet (author)
- Rozell, B (author)
- Toftgard, RKarolinska Institutet (author)
- Sur, IKarolinska Institutet (author)
- Karolinska Institutet (creator_code:org_t)
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- In:Transgenic research: Springer Science and Business Media LLC30:5, s. 701-7071573-93680962-8819
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