Syndecan-1 Expression Is Increased in the Aortic Wall of Patients with Type 2 Diabetes but Is Unrelated to Elevated Fasting Plasma Glucagon-Like Peptide-1

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Ntika, SKarolinska Institutet (författare)

Syndecan-1 Expression Is Increased in the Aortic Wall of Patients with Type 2 Diabetes but Is Unrelated to Elevated Fasting Plasma Glucagon-Like Peptide-1

Artikel/kapitelEngelska2021

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2021-06-20
MDPI AG,2021

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LIBRIS-ID:oai:prod.swepub.kib.ki.se:146930742
http://kipublications.ki.se/Default.aspx?queryparsed=id:146930742URI
https://doi.org/10.3390/biomedicines9060697DOI

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Språk:engelska
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A reduced prevalence of a thoracic aortic aneurysm (thoracic AA) is observed in type 2 diabetes (T2D). Glucagon-like peptide-1 (GLP-1)/GLP-1-based anti-diabetic therapy has indicated protective effects in thoracic AA and regulates the processes controlling the vascular tissue expression of Syndecan-1 (Sdc-1). Sdc-1 expression on macrophages infiltrating the aortic tissue contributes to a counter-regulatory response to thoracic AA formation in animal models through the interplay with inflammation/proteolytic activity. We hypothesized that elevated fasting plasma GLP-1 (fpGLP-1) increases the aortic Sdc-1 expression in T2D, which may contribute to a reduced prevalence of thoracic AA. Consequently, we determined whether T2D/thoracic AA associates with an altered Sdc-1 expression in the aortic tissue and the possible associations with fpGLP-1 and inflammation/proteolytic activity. From a cohort of surgical patients with an aortic valve pathology, we compared different disease groups (T2D/thoracic AA) with the same sub-cohort group of controls (patients without T2D and thoracic AA). The MMP-2 activity and Sdc-1, GLP-1R and CD68 expression were analyzed in the aortic tissue. GLP-1, Sdc-1 and cytokines were analyzed in the plasma. The aortic Sdc-1 expression was increased in T2D patients but did not correlate with fpGLP-1. Thoracic AA was associated with an increased aortic expression of Sdc-1 and the macrophage marker CD68. CD68 was not detected in T2D. In conclusion, an increased aortic Sdc-1 expression may contribute to a reduced prevalence of thoracic AA in T2D.

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Tracy, LM (författare)
Franco-Cereceda, AKarolinska Institutet (författare)
Bjorck, HMKarolinska Institutet (författare)
Krizhanovskii, C (författare)
Karolinska Institutet (creator_code:org_t)

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Ingår i:Biomedicines: MDPI AG9:62227-9059

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Av författaren/redakt...: Ntika, S; Tracy, LM; Franco-Cereceda, ...; Bjorck, HM; Krizhanovskii, C

Artiklar i publikationen: Biomedicines

Av lärosätet: Karolinska Institutet

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