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The γ-tubulin meshw...
The γ-tubulin meshwork assists in the recruitment of PCNA to chromatin in mammalian cells
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- Corvaisier, Matthieu (author)
- Lund University,Lunds universitet,Molekylär patologi, Malmö,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Molecular Pathology, Malmö,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital
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- Zhou, Jingkai (author)
- Lund University,Lunds universitet,Molekylär patologi, Malmö,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Molecular Pathology, Malmö,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital
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- Malycheva, Darina (author)
- Lund University,Lunds universitet,Molekylär patologi, Malmö,Forskargrupper vid Lunds universitet,Molecular Pathology, Malmö,Lund University Research Groups,Skåne University Hospital
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- Cornella, Nicola (author)
- Lund University,Lunds universitet,Molekylär patologi, Malmö,Forskargrupper vid Lunds universitet,Molecular Pathology, Malmö,Lund University Research Groups,Skåne University Hospital
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- Chioureas, D (author)
- Karolinska Institutet
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- Gustafsson, NMS (author)
- Karolinska Institutet
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- Rossello, CA (author)
- Lund University,Skåne University Hospital
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- Ayora, S (author)
- CSIC National Center for Biotechnology (CNB)
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- Li, TB (author)
- Accura science LLC
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- Ekström-Holka, Kristina (author)
- Lund University,Lunds universitet,Molekylär patologi, Malmö,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Molecular Pathology, Malmö,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital
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- Jirström, Karin (author)
- Lund University,Lunds universitet,Terapeutisk patologi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Therapeutic pathology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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- Lindström, Lisa (author)
- Lund University,Lunds universitet,Molekylär patologi, Malmö,Forskargrupper vid Lunds universitet,Molecular Pathology, Malmö,Lund University Research Groups
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- Alvarado Kristensson, Maria (author)
- Lund University,Lunds universitet,Molekylär patologi, Malmö,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Molecular Pathology, Malmö,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital
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(creator_code:org_t)
- 2021-06-22
- 2021
- English.
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In: Communications biology. - : Springer Science and Business Media LLC. - 2399-3642. ; 4:1, s. 767-
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http://dx.doi.org/10... (free)
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Abstract
Subject headings
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- Changes in the location of γ-tubulin ensure cell survival and preserve genome integrity. We investigated whether the nuclear accumulation of γ-tubulin facilitates the transport of proliferating cell nuclear antigen (PCNA) between the cytosolic and the nuclear compartment in mammalian cells. We found that the γ-tubulin meshwork assists in the recruitment of PCNA to chromatin. Also, decreased levels of γ-tubulin reduce the nuclear pool of PCNA. In addition, the γ-tubulin C terminus encodes a PCNA-interacting peptide (PIP) motif, and a γ-tubulin–PIP-mutant affects the nuclear accumulation of PCNA. In a cell-free system, PCNA and γ-tubulin formed a complex. In tumors, there is a significant positive correlation between TUBG1 and PCNA expression. Thus, we report a novel mechanism that constitutes the basis for tumor growth by which the γ-tubulin meshwork maintains indefinite proliferation by acting as an opportune scaffold for the transport of PCNA from the cytosol to the chromatin.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Corvaisier, Matt ...
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Zhou, Jingkai
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Malycheva, Darin ...
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Cornella, Nicola
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Chioureas, D
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Gustafsson, NMS
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show more...
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Rossello, CA
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Ayora, S
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Li, TB
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Ekström-Holka, K ...
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Jirström, Karin
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Lindström, Lisa
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Alvarado Kristen ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
- Articles in the publication
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Communications b ...
- By the university
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Karolinska Institutet
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Lund University