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Risk of depression ...
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Longinetti, EKarolinska Institutet
(författare)
Risk of depression in multiple sclerosis across disease-modifying therapies
- Artikel/kapitelEngelska2022
Förlag, utgivningsår, omfång ...
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2021-07-15
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SAGE Publications,2022
Nummerbeteckningar
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:147155142
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http://kipublications.ki.se/Default.aspx?queryparsed=id:147155142URI
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https://doi.org/10.1177/13524585211031128DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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Depression and use of antidepressants are more common among patients with multiple sclerosis (MS) compared to the general population, but the relation of psychiatric comorbidity to use of different disease-modifying therapies (DMTs) is less clear. Objective: To determine whether risk of incident depression or antidepressant use differed across DMTs, and to assess whether depression and antidepressants affected risk of DMT discontinuation and MS relapses. Methods: We prospectively followed for 8 years a register-based nationwide cohort of 3803 relapsing-remitting MS patients. Results: Patients on rituximab had a lower risk of being diagnosed with depression or initiating antidepressants compared with the reference group treated with interferons (hazard ratio (HR) = 0.72, 95% confidence interval (CI) = 0.54–0.96). Patients diagnosed with depression discontinued interferon treatment to a higher extent than patients without depression (HR = 1.51; 95% CI = 1.15–1.98), as did patients on fingolimod initiating an antidepressant compared to patients who did not initiate an antidepressant (HR = 1.47; 95% CI = 1.04–2.08). Conclusions: Our results indicate that the choice of DMT is associated with subsequent risk of depression in MS, but further studies are needed to establish whether there is a causal link. Overall, depression and use of antidepressants displayed limited associations with DMT discontinuation and MS relapse.
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Frisell, TKarolinska Institutet
(författare)
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Englund, SKarolinska Institutet
(författare)
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Reutfors, JKarolinska Institutet
(författare)
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Fang, FKarolinska Institutet
(författare)
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Piehl, FKarolinska Institutet
(författare)
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Karolinska Institutet
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Multiple sclerosis (Houndmills, Basingstoke, England): SAGE Publications28:4, s. 632-6411477-09701352-4585
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