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Preexisting autoant...
Preexisting autoantibodies to type I IFNs underlie critical COVID-19 pneumonia in patients with APS-1
- Article/chapterEnglish2021
Publisher, publication year, extent ...
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2021-04-23
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Rockefeller University Press,2021
Numbers
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:147389237
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http://kipublications.ki.se/Default.aspx?queryparsed=id:147389237URI
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https://doi.org/10.1084/jem.20210554DOI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Patients with biallelic loss-of-function variants of AIRE suffer from autoimmune polyendocrine syndrome type-1 (APS-1) and produce a broad range of autoantibodies (auto-Abs), including circulating auto-Abs neutralizing most type I interferons (IFNs). These auto-Abs were recently reported to account for at least 10% of cases of life-threatening COVID-19 pneumonia in the general population. We report 22 APS-1 patients from 21 kindreds in seven countries, aged between 8 and 48 yr and infected with SARS-CoV-2 since February 2020. The 21 patients tested had auto-Abs neutralizing IFN-α subtypes and/or IFN-ω; one had anti–IFN-β and another anti–IFN-ε, but none had anti–IFN-κ. Strikingly, 19 patients (86%) were hospitalized for COVID-19 pneumonia, including 15 (68%) admitted to an intensive care unit, 11 (50%) who required mechanical ventilation, and four (18%) who died. Ambulatory disease in three patients (14%) was possibly accounted for by prior or early specific interventions. Preexisting auto-Abs neutralizing type I IFNs in APS-1 patients confer a very high risk of life-threatening COVID-19 pneumonia at any age.
Added entries (persons, corporate bodies, meetings, titles ...)
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Orlova, E
(author)
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Sozaeva, L
(author)
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Levy, R
(author)
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James, A
(author)
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Schmitt, MM
(author)
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Ochoa, S
(author)
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Kareva, M
(author)
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Rodina, Y
(author)
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Gervais, A
(author)
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Le Voyer, T
(author)
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Rosain, J
(author)
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Philippot, Q
(author)
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Neehus, AL
(author)
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Shaw, E
(author)
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Migaud, M
(author)
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Bizien, L
(author)
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Ekwall, O
(author)
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Berg, S
(author)
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Beccuti, G
(author)
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Ghizzoni, L
(author)
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Thiriez, G
(author)
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Pavot, A
(author)
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Goujard, C
(author)
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Fremond, ML
(author)
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Carter, E
(author)
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Rothenbuhler, A
(author)
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Linglart, A
(author)
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Mignot, B
(author)
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Comte, A
(author)
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Cheikh, N
(author)
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Hermine, O
(author)
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Breivik, L
(author)
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Husebye, ES
(author)
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Humbert, S
(author)
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Rohrlich, P
(author)
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Coaquette, A
(author)
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Vuoto, F
(author)
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Faure, K
(author)
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Mahlaoui, N
(author)
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Kotnik, P
(author)
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Battelino, T
(author)
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Podkrajsek, KT
(author)
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Kisand, K
(author)
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Ferre, EMN
(author)
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DiMaggio, T
(author)
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Rosen, LB
(author)
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Burbelo, PD
(author)
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McIntyre, M
(author)
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Kann, NY
(author)
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Shcherbina, A
(author)
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Pavlova, M
(author)
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Kolodkina, A
(author)
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Holland, SM
(author)
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Zhang, SY
(author)
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Crow, YJ
(author)
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Notarangelo, LD
(author)
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Su, HC
(author)
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Abel, L
(author)
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Anderson, MS
(author)
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Jouanguy, E
(author)
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Neven, B
(author)
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Puel, A
(author)
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Casanova, JL
(author)
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Lionakis, MS
(author)
Related titles
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In:The Journal of experimental medicine: Rockefeller University Press218:71540-95380022-1007
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Find in a library
To the university's database
- By the author/editor
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Bastard, P
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Orlova, E
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Sozaeva, L
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Levy, R
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James, A
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Schmitt, MM
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show more...
-
Ochoa, S
-
Kareva, M
-
Rodina, Y
-
Gervais, A
-
Le Voyer, T
-
Rosain, J
-
Philippot, Q
-
Neehus, AL
-
Shaw, E
-
Migaud, M
-
Bizien, L
-
Ekwall, O
-
Berg, S
-
Beccuti, G
-
Ghizzoni, L
-
Thiriez, G
-
Pavot, A
-
Goujard, C
-
Fremond, ML
-
Carter, E
-
Rothenbuhler, A
-
Linglart, A
-
Mignot, B
-
Comte, A
-
Cheikh, N
-
Hermine, O
-
Breivik, L
-
Husebye, ES
-
Humbert, S
-
Rohrlich, P
-
Coaquette, A
-
Vuoto, F
-
Faure, K
-
Mahlaoui, N
-
Kotnik, P
-
Battelino, T
-
Podkrajsek, KT
-
Kisand, K
-
Ferre, EMN
-
DiMaggio, T
-
Rosen, LB
-
Burbelo, PD
-
McIntyre, M
-
Kann, NY
-
Shcherbina, A
-
Pavlova, M
-
Kolodkina, A
-
Holland, SM
-
Zhang, SY
-
Crow, YJ
-
Notarangelo, LD
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Su, HC
-
Abel, L
-
Anderson, MS
-
Jouanguy, E
-
Neven, B
-
Puel, A
-
Casanova, JL
-
Lionakis, MS
-
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- Articles in the publication
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The Journal of e ...
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Karolinska Institutet