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Association between...
Association between polygenic propensity for psychiatric disorders and nutrient intake
- Article/chapterEnglish2021
Publisher, publication year, extent ...
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2021-08-26
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Springer Science and Business Media LLC,2021
Numbers
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:147480112
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http://kipublications.ki.se/Default.aspx?queryparsed=id:147480112URI
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https://doi.org/10.1038/s42003-021-02469-4DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Despite the observed associations between psychiatric disorders and nutrient intake, genetic studies are limited. We examined whether polygenic scores for psychiatric disorders are associated with nutrient intake in UK Biobank (N = 163,619) using linear mixed models. We found polygenic scores for attention-deficit/hyperactivity disorder, bipolar disorder, and schizophrenia showed the highest number of associations, while a polygenic score for autism spectrum disorder showed no association. The relatively weaker obsessive-compulsive disorder polygenic score showed the greatest effect sizes suggesting its association with diet traits may become more apparent with larger genome-wide analyses. A higher alcohol dependence polygenic score was associated with higher alcohol intake and individuals with higher persistent thinness polygenic scores reported their food to weigh less, both independent of socioeconomic status. Our findings suggest that polygenic propensity for a psychiatric disorder is associated with dietary behaviour. Note, nutrient intake was self-reported and findings must therefore be interpreted mindfully.
Added entries (persons, corporate bodies, meetings, titles ...)
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Hubel, CKarolinska Institutet
(author)
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Lin, YH
(author)
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Eley, TC
(author)
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Breen, G
(author)
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Karolinska Institutet
(creator_code:org_t)
Related titles
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In:Communications biology: Springer Science and Business Media LLC4:1, s. 965-2399-3642
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