Search: id:"swepub:oai:prod.swepub.kib.ki.se:147550283" >
Role of the PD-1/PD...
Role of the PD-1/PD-L1 Signaling in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis: Recent Insights and Future Directions
- Article/chapterEnglish2021
Publisher, publication year, extent ...
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2021-09-03
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Springer Science and Business Media LLC,2021
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:147550283
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http://kipublications.ki.se/Default.aspx?queryparsed=id:147550283URI
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https://doi.org/10.1007/s12035-021-02495-7DOI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Multiple sclerosis (MS) is an autoimmunity-related chronic demyelination disease of the central nervous system (CNS), causing young disability. Currently, highly specific immunotherapies for MS are still lacking. Programmed cell death 1 (PD-1) is an immunosuppressive co-stimulatory molecule, which is expressed on activated T lymphocytes, B lymphocytes, natural killer cells, and other immune cells. PD-L1, the ligand of PD-1, is expressed on T lymphocytes, B lymphocytes, dendritic cells, and macrophages. PD-1/PD-L1 delivers negative regulatory signals to immune cells, maintaining immune tolerance and inhibiting autoimmunity. This review comprehensively summarizes current insights into the role of PD-1/PD-L1 signaling in MS and its animal model experimental autoimmune encephalomyelitis (EAE). The potentiality of PD-1/PD-L1 as biomarkers or therapeutic targets for MS will also be discussed.
Added entries (persons, corporate bodies, meetings, titles ...)
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Han, JM
(author)
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Zhu, J
(author)
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Jin, T
(author)
Related titles
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In:Molecular neurobiology: Springer Science and Business Media LLC58:12, s. 6249-62711559-11820893-7648
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