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Targeting SARS-CoV-...
Targeting SARS-CoV-2 receptor-binding domain to cells expressing CD40 improves protection to infection in convalescent macaques
- Article/chapterEnglish2021
Publisher, publication year, extent ...
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2021-09-01
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Springer Science and Business Media LLC,2021
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:147601739
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http://kipublications.ki.se/Default.aspx?queryparsed=id:147601739URI
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https://doi.org/10.1038/s41467-021-25382-0DOI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Achieving sufficient worldwide vaccination coverage against SARS-CoV-2 will require additional approaches to currently approved viral vector and mRNA vaccines. Subunit vaccines may have distinct advantages when immunizing vulnerable individuals, children and pregnant women. Here, we present a new generation of subunit vaccines targeting viral antigens to CD40-expressing antigen-presenting cells. We demonstrate that targeting the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein to CD40 (αCD40.RBD) induces significant levels of specific T and B cells, with long-term memory phenotypes, in a humanized mouse model. Additionally, we demonstrate that a single dose of the αCD40.RBD vaccine, injected without adjuvant, is sufficient to boost a rapid increase in neutralizing antibodies in convalescent non-human primates (NHPs) exposed six months previously to SARS-CoV-2. Vaccine-elicited antibodies cross-neutralize different SARS-CoV-2 variants, including D614G, B1.1.7 and to a lesser extent B1.351. Such vaccination significantly improves protection against a new high-dose virulent challenge versus that in non-vaccinated convalescent animals.
Added entries (persons, corporate bodies, meetings, titles ...)
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Godot, V
(author)
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Cardinaud, S
(author)
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Galhaut, M
(author)
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Coleon, S
(author)
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Zurawski, S
(author)
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Dereuddre-Bosquet, N
(author)
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Cavarelli, M
(author)
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Gallouet, AS
(author)
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Maisonnasse, P
(author)
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Dupaty, L
(author)
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Fenwick, C
(author)
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Naninck, T
(author)
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Lemaitre, J
(author)
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Gomez-Pacheco, M
(author)
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Kahlaoui, N
(author)
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Contreras, V
(author)
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Relouzat, F
(author)
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Fang, RHT
(author)
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Wang, ZQ
(author)
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Ellis, J
(author)
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Chapon, C
(author)
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Centlivre, M
(author)
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Wiedemann, A
(author)
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Lacabaratz, C
(author)
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Surenaud, M
(author)
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Szurgot, I
(author)
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Liljestrom, P
(author)
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Planas, D
(author)
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Bruel, T
(author)
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Schwartz, O
(author)
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van der Werf, S
(author)
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Pantaleo, G
(author)
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Prague, M
(author)
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Thiebaut, R
(author)
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Zurawski, G
(author)
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Levy, Y
(author)
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Le Grand, R
(author)
Related titles
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In:Nature communications: Springer Science and Business Media LLC12:1, s. 5215-2041-1723
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Marlin, R
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Godot, V
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Cardinaud, S
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Galhaut, M
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Coleon, S
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Zurawski, S
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show more...
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Dereuddre-Bosque ...
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Cavarelli, M
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Gallouet, AS
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Maisonnasse, P
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Dupaty, L
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Fenwick, C
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Naninck, T
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Lemaitre, J
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Gomez-Pacheco, M
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Kahlaoui, N
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Contreras, V
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Relouzat, F
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Fang, RHT
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Wang, ZQ
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Ellis, J
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Chapon, C
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Centlivre, M
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Wiedemann, A
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Lacabaratz, C
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Surenaud, M
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Szurgot, I
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Liljestrom, P
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Planas, D
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Bruel, T
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Schwartz, O
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van der Werf, S
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Pantaleo, G
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Prague, M
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Thiebaut, R
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Zurawski, G
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Levy, Y
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Le Grand, R
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Nature communica ...
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Karolinska Institutet