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A multimodal cell c...
A multimodal cell census and atlas of the mammalian primary motor cortex
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Callaway, EM (author)
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Dong, HW (author)
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Ecker, JR (author)
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show more...
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Hawrylycz, MJ (author)
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Huang, ZJ (author)
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Lein, ES (author)
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Ngai, J (author)
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Osten, P (author)
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Ren, B (author)
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Tolias, AS (author)
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White, O (author)
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Zeng, HK (author)
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Zhuang, XW (author)
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Ascoli, GA (author)
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Behrens, MM (author)
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Chun, J (author)
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Feng, GP (author)
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Gee, JC (author)
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Ghosh, SS (author)
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Halchenko, YO (author)
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Hertzano, R (author)
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Lim, BK (author)
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Martone, ME (author)
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Ng, L (author)
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Pachter, L (author)
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Ropelewski, AJ (author)
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Tickle, TL (author)
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Yang, XW (author)
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Zhang, K (author)
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Bakken, TE (author)
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Berens, P (author)
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Daigle, TL (author)
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Harris, JA (author)
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Jorstad, NL (author)
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Kalmbach, BE (author)
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Kobak, D (author)
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Li, YE (author)
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Liu, HQ (author)
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Matho, KS (author)
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Mukamel, EA (author)
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Naeemi, M (author)
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Scala, F (author)
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Tan, PC (author)
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Ting, JT (author)
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Xie, FM (author)
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Zhang, M (author)
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Zhang, ZZ (author)
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Zhou, JT (author)
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Zingg, B (author)
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Bertagnolli, D (author)
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Casper, T (author)
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Crichton, K (author)
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Dee, N (author)
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Diep, D (author)
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Ding, SL (author)
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Dong, WX (author)
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Dougherty, EL (author)
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Fong, O (author)
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Goldman, M (author)
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Goldy, J (author)
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Hodge, RD (author)
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Hu, LJ (author)
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Keene, CD (author)
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Krienen, FM (author)
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Kroll, M (author)
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Lake, BB (author)
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Lathia, K (author)
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- Linnarsson, S (author)
- Karolinska Institutet
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Liu, CS (author)
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Macosko, EZ (author)
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McCarroll, SA (author)
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McMillen, D (author)
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Nadaf, NM (author)
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Nguyen, TN (author)
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Palmer, CR (author)
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Pham, T (author)
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Plongthongkum, N (author)
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Reed, NM (author)
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Regev, A (author)
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Rimorin, C (author)
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Romanow, WJ (author)
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Savoia, S (author)
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Siletti, K (author)
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Smith, K (author)
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Sulc, J (author)
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Tasic, B (author)
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Tieu, M (author)
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Torkelson, A (author)
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Tung, H (author)
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van Velthoven, CTJ (author)
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Vanderburg, CR (author)
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Yanny, AM (author)
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Fang, RX (author)
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Hou, XM (author)
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Lucero, JD (author)
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Osteen, JK (author)
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Pinto-Duarte, A (author)
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Poirion, O (author)
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Preissl, S (author)
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Wang, XX (author)
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Aldridge, A (author)
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Bartlett, A (author)
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Boggeman, L (author)
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O'Connor, C (author)
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Castanon, RG (author)
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Chen, HM (author)
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Fitzpatrick, C (author)
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Luo, CY (author)
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Nery, JR (author)
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Nunn, M (author)
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Rivkin, AC (author)
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Tian, W (author)
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Dominguez, B (author)
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Ito-Cole, T (author)
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Jacobs, M (author)
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Jin, X (author)
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Lee, CT (author)
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Lee, KF (author)
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Miyazaki, PA (author)
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Pang, Y (author)
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Rashid, M (author)
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Smith, JB (author)
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Vu, M (author)
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Williams, E (author)
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Armand, E (author)
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Biancalani, T (author)
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Booeshaghi, AS (author)
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Crow, M (author)
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Dudoit, S (author)
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Fischer, S (author)
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Gillis, J (author)
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Hu, QW (author)
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Kharchenko, P (author)
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Niu, SY (author)
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Ntranos, V (author)
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Purdom, E (author)
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Risso, D (author)
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de Bezieux, HR (author)
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Somasundaram, S (author)
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Street, K (author)
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Svensson, V (author)
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Vaishnav, ED (author)
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Van den Berge, K (author)
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Welch, JD (author)
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Yao, ZZ (author)
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An, X (author)
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Bateup, HS (author)
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Bowman, I (author)
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Chance, RK (author)
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Foster, NN (author)
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Galbavy, W (author)
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Gong, H (author)
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Gou, L (author)
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Hatfield, JT (author)
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Hintiryan, H (author)
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Hirokawa, KE (author)
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Kim, G (author)
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Kramer, DJ (author)
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Li, AA (author)
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Li, XN (author)
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Luo, QM (author)
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Munoz-Castaneda, R (author)
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Stafford, DA (author)
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Feng, Z (author)
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Jia, XY (author)
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Jiang, SD (author)
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Jiang, T (author)
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Kuang, XL (author)
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Larsen, R (author)
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Lesnar, P (author)
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Li, YY (author)
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Li, YY (author)
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Liu, LJ (author)
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Peng, HC (author)
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Qu, L (author)
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Ren, M (author)
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Ruan, ZC (author)
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Shen, E (author)
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Song, YY (author)
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Wakeman, W (author)
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Wang, P (author)
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Wang, YM (author)
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Wang, Y (author)
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Yin, LL (author)
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Yuan, J (author)
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Zhao, SJ (author)
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Zhao, X (author)
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Narasimhan, A (author)
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Palaniswamy, R (author)
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Banerjee, S (author)
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Ding, LY (author)
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Huilgol, D (author)
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Huo, BX (author)
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Kuo, HC (author)
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Laturnus, S (author)
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Li, X (author)
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Mitra, PP (author)
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Mizrachi, J (author)
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Wang, QX (author)
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Xie, P (author)
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Xiong, F (author)
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Yu, Y (author)
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Eichhorn, SW (author)
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Berg, J (author)
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Bernabucci, M (author)
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Bernaerts, Y (author)
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Cadwell, CR (author)
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Castro, JR (author)
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Dalley, R (author)
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- Hartmanis, L (author)
- Karolinska Institutet
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Horwitz, GD (author)
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Jiang, XL (author)
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Ko, AL (author)
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Miranda, E (author)
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Mulherkar, S (author)
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Nicovich, PR (author)
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Owen, SF (author)
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- Sandberg, R (author)
- Karolinska Institutet
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Sorensen, SA (author)
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Tan, ZH (author)
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Allen, S (author)
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Hockemeyer, D (author)
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Lee, AY (author)
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Veldman, MB (author)
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Adkins, RS (author)
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Ament, SA (author)
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Bravo, HC (author)
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Carter, R (author)
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Chatterjee, A (author)
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Colantuoni, C (author)
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Crabtree, J (author)
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Creasy, H (author)
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Felix, V (author)
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Giglio, M (author)
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Herb, BR (author)
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Kancherla, J (author)
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Mahurkar, A (author)
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McCracken, C (author)
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Nickel, L (author)
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Olley, D (author)
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Orvis, J (author)
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Schor, M (author)
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Hood, G (author)
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Dichter, B (author)
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Grauer, M (author)
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Helba, B (author)
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Bandrowski, A (author)
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Barkas, N (author)
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Carlin, B (author)
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D'Orazi, FD (author)
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Degatano, K (author)
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Gillespie, TH (author)
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Khajouei, F (author)
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Konwar, K (author)
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Thompson, C (author)
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Kelly, K (author)
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Mok, S (author)
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Sunkin, S (author)
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show less...
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(creator_code:org_t)
- 2021-10-06
- 2021
- English.
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In: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 598:7879, s. 86-102
- Related links:
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https://www.nature.c...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Here we report the generation of a multimodal cell census and atlas of the mammalian primary motor cortex as the initial product of the BRAIN Initiative Cell Census Network (BICCN). This was achieved by coordinated large-scale analyses of single-cell transcriptomes, chromatin accessibility, DNA methylomes, spatially resolved single-cell transcriptomes, morphological and electrophysiological properties and cellular resolution input–output mapping, integrated through cross-modal computational analysis. Our results advance the collective knowledge and understanding of brain cell-type organization1–5. First, our study reveals a unified molecular genetic landscape of cortical cell types that integrates their transcriptome, open chromatin and DNA methylation maps. Second, cross-species analysis achieves a consensus taxonomy of transcriptomic types and their hierarchical organization that is conserved from mouse to marmoset and human. Third, in situ single-cell transcriptomics provides a spatially resolved cell-type atlas of the motor cortex. Fourth, cross-modal analysis provides compelling evidence for the transcriptomic, epigenomic and gene regulatory basis of neuronal phenotypes such as their physiological and anatomical properties, demonstrating the biological validity and genomic underpinning of neuron types. We further present an extensive genetic toolset for targeting glutamatergic neuron types towards linking their molecular and developmental identity to their circuit function. Together, our results establish a unifying and mechanistic framework of neuronal cell-type organization that integrates multi-layered molecular genetic and spatial information with multi-faceted phenotypic properties.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
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Nature
(Search for host publication in LIBRIS)
To the university's database
- By the author/editor
-
Callaway, EM
-
Dong, HW
-
Ecker, JR
-
Hawrylycz, MJ
-
Huang, ZJ
-
Lein, ES
-
show more...
-
Ngai, J
-
Osten, P
-
Ren, B
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Tolias, AS
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White, O
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Zeng, HK
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Zhuang, XW
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Ascoli, GA
-
Behrens, MM
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Chun, J
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Feng, GP
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Gee, JC
-
Ghosh, SS
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Halchenko, YO
-
Hertzano, R
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Lim, BK
-
Martone, ME
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Ng, L
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Pachter, L
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Ropelewski, AJ
-
Tickle, TL
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Yang, XW
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Zhang, K
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Bakken, TE
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Berens, P
-
Daigle, TL
-
Harris, JA
-
Jorstad, NL
-
Kalmbach, BE
-
Kobak, D
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Li, YE
-
Liu, HQ
-
Matho, KS
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Mukamel, EA
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Naeemi, M
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Scala, F
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Tan, PC
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Ting, JT
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Xie, FM
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Zhang, M
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Zhang, ZZ
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Zhou, JT
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Zingg, B
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Bertagnolli, D
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Casper, T
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Crichton, K
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Dee, N
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Diep, D
-
Ding, SL
-
Dong, WX
-
Dougherty, EL
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Fong, O
-
Goldman, M
-
Goldy, J
-
Hodge, RD
-
Hu, LJ
-
Keene, CD
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Krienen, FM
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Kroll, M
-
Lake, BB
-
Lathia, K
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Linnarsson, S
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Liu, CS
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Macosko, EZ
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McCarroll, SA
-
McMillen, D
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Nadaf, NM
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Nguyen, TN
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Palmer, CR
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Pham, T
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Plongthongkum, N
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Reed, NM
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Regev, A
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Rimorin, C
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Romanow, WJ
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Savoia, S
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Siletti, K
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Smith, K
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Sulc, J
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Tasic, B
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Tieu, M
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Torkelson, A
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Tung, H
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van Velthoven, C ...
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Vanderburg, CR
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Yanny, AM
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Fang, RX
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Hou, XM
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Lucero, JD
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Osteen, JK
-
Pinto-Duarte, A
-
Poirion, O
-
Preissl, S
-
Wang, XX
-
Aldridge, A
-
Bartlett, A
-
Boggeman, L
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O'Connor, C
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Castanon, RG
-
Chen, HM
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Fitzpatrick, C
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Luo, CY
-
Nery, JR
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Nunn, M
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Rivkin, AC
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Tian, W
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Dominguez, B
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Ito-Cole, T
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Jacobs, M
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Jin, X
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Lee, CT
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Lee, KF
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Miyazaki, PA
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Pang, Y
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Rashid, M
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Smith, JB
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Vu, M
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Williams, E
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Armand, E
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Biancalani, T
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Booeshaghi, AS
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Crow, M
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Dudoit, S
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Fischer, S
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Gillis, J
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Hu, QW
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Kharchenko, P
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Niu, SY
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Ntranos, V
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Purdom, E
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Risso, D
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de Bezieux, HR
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Somasundaram, S
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Street, K
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Svensson, V
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Vaishnav, ED
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Van den Berge, K
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Welch, JD
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Yao, ZZ
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An, X
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Bateup, HS
-
Bowman, I
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Chance, RK
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Foster, NN
-
Galbavy, W
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Gong, H
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Gou, L
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Hatfield, JT
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Hintiryan, H
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Hirokawa, KE
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Kim, G
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Kramer, DJ
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Li, AA
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Li, XN
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Luo, QM
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Munoz-Castaneda, ...
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Stafford, DA
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Feng, Z
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Jia, XY
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Jiang, SD
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Jiang, T
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Kuang, XL
-
Larsen, R
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Lesnar, P
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Li, YY
-
Liu, LJ
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Peng, HC
-
Qu, L
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Ren, M
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Ruan, ZC
-
Shen, E
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Song, YY
-
Wakeman, W
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Wang, P
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Wang, YM
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Wang, Y
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Yin, LL
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Yuan, J
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Zhao, SJ
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Zhao, X
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Narasimhan, A
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Palaniswamy, R
-
Banerjee, S
-
Ding, LY
-
Huilgol, D
-
Huo, BX
-
Kuo, HC
-
Laturnus, S
-
Li, X
-
Mitra, PP
-
Mizrachi, J
-
Wang, QX
-
Xie, P
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Xiong, F
-
Yu, Y
-
Eichhorn, SW
-
Berg, J
-
Bernabucci, M
-
Bernaerts, Y
-
Cadwell, CR
-
Castro, JR
-
Dalley, R
-
Hartmanis, L
-
Horwitz, GD
-
Jiang, XL
-
Ko, AL
-
Miranda, E
-
Mulherkar, S
-
Nicovich, PR
-
Owen, SF
-
Sandberg, R
-
Sorensen, SA
-
Tan, ZH
-
Allen, S
-
Hockemeyer, D
-
Lee, AY
-
Veldman, MB
-
Adkins, RS
-
Ament, SA
-
Bravo, HC
-
Carter, R
-
Chatterjee, A
-
Colantuoni, C
-
Crabtree, J
-
Creasy, H
-
Felix, V
-
Giglio, M
-
Herb, BR
-
Kancherla, J
-
Mahurkar, A
-
McCracken, C
-
Nickel, L
-
Olley, D
-
Orvis, J
-
Schor, M
-
Hood, G
-
Dichter, B
-
Grauer, M
-
Helba, B
-
Bandrowski, A
-
Barkas, N
-
Carlin, B
-
D'Orazi, FD
-
Degatano, K
-
Gillespie, TH
-
Khajouei, F
-
Konwar, K
-
Thompson, C
-
Kelly, K
-
Mok, S
-
Sunkin, S
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Neurosciences
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Medical Genetics
- Articles in the publication
-
Nature
- By the university
-
Karolinska Institutet