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Fractional flow res...
Fractional flow reserve-guided percutaneous coronary intervention vs. medical therapy for patients with stable coronary lesions : meta-analysis of individual patient data
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- Zimmermann, Frederik M. (författare)
- Catharina Hospital
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- Omerovic, Elmir (författare)
- Sahlgrenska University Hospital
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- Fournier, Stephane (författare)
- Hartcentrum OLV Aalst,Lausanne University Hospital
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- Kelbæk, Henning (författare)
- Zealand University Hospital
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- Johnson, Nils P. (författare)
- University of Texas Health Science Center at Houston,Memorial Hermann-Texas Medical Center
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- Rothenbühler, Martina (författare)
- University of Bern
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- Xaplanteris, Panagiotis (författare)
- Hartcentrum OLV Aalst
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- Abdel-Wahab, Mohamed (författare)
- Segeberger Kliniken
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- Barbato, Emanuele (författare)
- University of Naples Federico II,Hartcentrum OLV Aalst
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- Høfsten, Dan Eik (författare)
- Copenhagen University Hospital,University of Copenhagen
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- Tonino, Pim A.L. (författare)
- Catharina Hospital
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- Boxma-de Klerk, Bianca M. (författare)
- Maasstad Ziekenhuis
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- Fearon, William F. (författare)
- Stanford University
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- Køber, Lars (författare)
- Copenhagen University Hospital,University of Copenhagen
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- Smits, Pieter C. (författare)
- Maasstad Ziekenhuis
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- De Bruyne, Bernard (författare)
- Lausanne University Hospital,Hartcentrum OLV Aalst
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- Pijls, Nico H.J. (författare)
- Eindhoven University of Technology,Catharina Hospital
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- Jüni, Peter (författare)
- University of Toronto,Saint Michael's Hospital
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- Engstrøm, Thomas (författare)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Copenhagen University Hospital,University of Copenhagen
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(creator_code:org_t)
- 2018-12-28
- 2019
- Engelska 7 s.
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Ingår i: European Heart Journal. - : Oxford University Press (OUP). - 1522-9645 .- 0195-668X. ; 40:2, s. 180-186
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://academic.oup...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Aims: To assess the effect of fractional flow reserve (FFR)-guided percutaneous coronary intervention (PCI) with contemporary drug-eluting stents on the composite of cardiac death or myocardial infarction (MI) vs. medical therapy in patients with stable coronary lesions. Methods and results: We performed a systematic review and meta-analysis of individual patient data (IPD) of the three available randomized trials of contemporary FFR-guided PCI vs. medical therapy for patients with stable coronary lesions: FAME 2 (NCT01132495), DANAMI-3-PRIMULTI (NCT01960933), and Compare-Acute (NCT01399736). FAME 2 enrolled patients with stable coronary artery disease (CAD), while the other two focused on non-culprit lesions in stabilized patients after acute coronary syndrome. A total of 2400 subjects were recruited from 54 sites world-wide with 1056 randomly assigned to FFR-guided PCI and 1344 to medical therapy. The pre-specified primary outcome was a composite of cardiac death or MI. We included data from extended follow-ups for FAME 2 (up to 5.5 years follow-up) and DANAMI-3-PRIMULTI (up to 4.7 years follow-up). After a median follow-up of 35 months (interquartile range 12-60 months), a reduction in the composite of cardiac death or MI was observed with FFR-guided PCI as compared with medical therapy (hazard ratio 0.72, 95% confidence interval 0.54-0.96; P = 0.02). The difference between groups was driven by MI. Conclusion: In this IPD meta-analysis of the three available randomized controlled trials to date, FFR-guided PCI resulted in a reduction of the composite of cardiac death or MI compared with medical therapy, which was driven by a decreased risk of MI.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
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Zimmermann, Fred ...
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Omerovic, Elmir
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Fournier, Stepha ...
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Kelbæk, Henning
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Johnson, Nils P.
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Rothenbühler, Ma ...
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visa fler...
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Xaplanteris, Pan ...
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Abdel-Wahab, Moh ...
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Barbato, Emanuel ...
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Høfsten, Dan Eik
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Tonino, Pim A.L.
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Boxma-de Klerk, ...
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Fearon, William ...
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Køber, Lars
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Smits, Pieter C.
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De Bruyne, Berna ...
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Pijls, Nico H.J.
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Jüni, Peter
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Engstrøm, Thomas
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
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European Heart J ...
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Lunds universitet