COVID-19 severity and mortality in patients with CLL: an update of the international ERIC and Campus CLL study

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Chatzikonstantinou, T (author)

COVID-19 severity and mortality in patients with CLL: an update of the international ERIC and Campus CLL study

Article/chapterEnglish2021

Publisher, publication year, extent ...

2021-11-01
Springer Science and Business Media LLC,2021

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LIBRIS-ID:oai:prod.swepub.kib.ki.se:148002911
http://kipublications.ki.se/Default.aspx?queryparsed=id:148002911URI
https://doi.org/10.1038/s41375-021-01450-8DOI
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-463478URI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Patients with chronic lymphocytic leukemia (CLL) may be more susceptible to Coronavirus disease 2019 (COVID-19) due to age, disease, and treatment-related immunosuppression. We aimed to assess risk factors of outcome and elucidate the impact of CLL-directed treatments on the course of COVID-19. We conducted a retrospective, international study, collectively including 941 patients with CLL and confirmed COVID-19. Data from the beginning of the pandemic until March 16, 2021, were collected from 91 centers. The risk factors of case fatality rate (CFR), disease severity, and overall survival (OS) were investigated. OS analysis was restricted to patients with severe COVID-19 (definition: hospitalization with need of oxygen or admission into an intensive care unit). CFR in patients with severe COVID-19 was 38.4%. OS was inferior for patients in all treatment categories compared to untreated (p < 0.001). Untreated patients had a lower risk of death (HR = 0.54, 95% CI:0.41–0.72). The risk of death was higher for older patients and those suffering from cardiac failure (HR = 1.03, 95% CI:1.02–1.04; HR = 1.79, 95% CI:1.04–3.07, respectively). Age, CLL-directed treatment, and cardiac failure were significant risk factors of OS. Untreated patients had a better chance of survival than those on treatment or recently treated.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Hematologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Hematology hsv//eng

Added entries (persons, corporate bodies, meetings, titles ...)

Kapetanakis, A (author)
Scarfo, L (author)
Karakatsoulis, G (author)
Allsup, D (author)
Cabrero, AA (author)
Andres, M (author)
Antic, D (author)
Baile, M (author)
Baliakas, Panagiotis,1977-Uppsala universitet,Experimentell och klinisk onkologi(Swepub:uu)panba345 (author)
Bron, D (author)
Capasso, A (author)
Chatzileontiadou, S (author)
Cordoba, R (author)
Correa, JG (author)
Cuellar-Garcia, C (author)
De Paoli, L (author)
Mattsson, MattiasUppsala universitet,Hematologi,Experimentell och klinisk onkologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)matma431 (author)
Del Poeta, G (author)
Demosthenous, C (author)
Dimou, M (author)
Donaldson, D (author)
Doubek, M (author)
Efstathopoulou, M (author)
Eichhorst, B (author)
El-Ashwah, S (author)
Enrico, A (author)
Espinet, B (author)
Farina, L (author)
Ferrari, A (author)
Foglietta, M (author)
Frederiksen, H (author)
Furstenau, M (author)
Garcia-Marco, JA (author)
Garcia-Serra, R (author)
Gentile, M (author)
Gimeno, E (author)
Glenthoj, A (author)
da Silva, MG (author)
Gutwein, O (author)
Hakobyan, YK (author)
Herishanu, Y (author)
Hernandez-Rivas, JA (author)
Herold, T (author)
Innocenti, I (author)
Itchaki, G (author)
Jaksic, O (author)
Janssens, A (author)
Kalashnikova, OB (author)
Kalicinska, E (author)
Karlsson, LK (author)
Kater, AP (author)
Kersting, S (author)
Labrador, J (author)
Lad, D (author)
Laurenti, L (author)
Levin, MD (author)
Lista, E (author)
Lopez-Garcia, A (author)
Malerba, L (author)
Marasca, R (author)
Marchetti, M (author)
Marquet, J (author)
Mattsson, M (author)
Mauro, FR (author)
Milosevic, I (author)
Miras, F (author)
Morawska, M (author)
Motta, M (author)
Munir, T (author)
Murru, R (author)
Niemann, CU (author)
Rodrigues, RN (author)
Olivieri, J (author)
Orsucci, L (author)
Papaioannou, M (author)
Pavlovsky, MA (author)
Piskunova, I (author)
Popov, VM (author)
Quaglia, FM (author)
Quaresmini, G (author)
Qvist, K (author)
Reda, G (author)
Rigolin, GM (author)
Ruchlemer, R (author)
Saghumyan, G (author)
Shrestha, A (author)
Simkovic, M (author)
Spacek, M (author)
Sportoletti, P (author)
Stanca, O (author)
Stavroyianni, N (author)
Tadmor, T (author)
Te Raa, D (author)
Tonino, SH (author)
Trentin, L (author)
Van der Spek, E (author)
van Gelder, M (author)
van Kampen, R (author)
Varettoni, M (author)
Visentin, A (author)
Vitale, C (author)
Wasik-Szczepanek, E (author)
Wrobel, T (author)
San Segundo, LY (author)
Yassin, M (author)
Coscia, M (author)
Rambaldi, A (author)
Montserrat, E (author)
Foa, R (author)
Cuneo, A (author)
Stamatopoulos, KKarolinska Institutet (author)
Ghia, P (author)
Kalashnikova, Оlga B. (author)
Uppsala universitetExperimentell och klinisk onkologi (creator_code:org_t)

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In:Leukemia: Springer Science and Business Media LLC35:12, s. 3444-34541476-55510887-6924

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By the author/editor: Chatzikonstantin ...; Kapetanakis, A; Scarfo, L; Karakatsoulis, G; Allsup, D; Cabrero, AA; show more...; Andres, M; Antic, D; Baile, M; Baliakas, Panagi ...; Bron, D; Capasso, A; Chatzileontiadou ...; Cordoba, R; Correa, JG; Cuellar-Garcia, ...; De Paoli, L; Mattsson, Mattia ...; Del Poeta, G; Demosthenous, C; Dimou, M; Donaldson, D; Doubek, M; Efstathopoulou, ...; Eichhorst, B; El-Ashwah, S; Enrico, A; Espinet, B; Farina, L; Ferrari, A; Foglietta, M; Frederiksen, H; Furstenau, M; Garcia-Marco, JA; Garcia-Serra, R; Gentile, M; Gimeno, E; Glenthoj, A; da Silva, MG; Gutwein, O; Hakobyan, YK; Herishanu, Y; Hernandez-Rivas, ...; Herold, T; Innocenti, I; Itchaki, G; Jaksic, O; Janssens, A; Kalashnikova, OB; Kalicinska, E; Karlsson, LK; Kater, AP; Kersting, S; Labrador, J; Lad, D; Laurenti, L; Levin, MD; Lista, E; Lopez-Garcia, A; Malerba, L; Marasca, R; Marchetti, M; Marquet, J; Mattsson, M; Mauro, FR; Milosevic, I; Miras, F; Morawska, M; Motta, M; Munir, T; Murru, R; Niemann, CU; Rodrigues, RN; Olivieri, J; Orsucci, L; Papaioannou, M; Pavlovsky, MA; Piskunova, I; Popov, VM; Quaglia, FM; Quaresmini, G; Qvist, K; Reda, G; Rigolin, GM; Ruchlemer, R; Saghumyan, G; Shrestha, A; Simkovic, M; Spacek, M; Sportoletti, P; Stanca, O; Stavroyianni, N; Tadmor, T; Te Raa, D; Tonino, SH; Trentin, L; Van der Spek, E; van Gelder, M; van Kampen, R; Varettoni, M; Visentin, A; Vitale, C; Wasik-Szczepanek ...; Wrobel, T; San Segundo, LY; Yassin, M; Coscia, M; Rambaldi, A; Montserrat, E; Foa, R; Cuneo, A; Stamatopoulos, K; Ghia, P; Kalashnikova, Оl ...; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Hematology

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