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  • Paquin-Proulx, D (author)

Preferential and persistent impact of acute HIV-1 infection on CD4+ iNKT cells in colonic mucosa

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • 2021-11-09
  • Proceedings of the National Academy of Sciences,2021

Numbers

  • LIBRIS-ID:oai:prod.swepub.kib.ki.se:148253777
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:148253777URI
  • https://doi.org/10.1073/pnas.2104721118DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Evidence suggests that HIV-1 disease progression is determined in the early stages of infection. Here, preinfection invariant natural killer T (iNKT) cell levels were predictive of the peak viral load during acute HIV-1 infection (AHI). Furthermore, iNKT cells were preferentially lost in AHI. This was particularly striking in the colonic mucosa, where iNKT cells were depleted more profoundly than conventional CD4+T cells. The initiation of antiretroviral therapy during AHI-prevented iNKT cell dysregulation in peripheral blood but not in the colonic mucosa. Overall, our results support a model in which iNKT cells are early and preferential targets for HIV-1 infection during AHI.

Added entries (persons, corporate bodies, meetings, titles ...)

  • Lal, KG (author)
  • Phuang-Ngern, Y (author)
  • Creegan, M (author)
  • Tokarev, A (author)
  • Suhkumvittaya, S (author)
  • Alrubayyi, A (author)
  • Kroon, E (author)
  • Pinyakorn, S (author)
  • Slike, BM (author)
  • Bolton, DL (author)
  • Krebs, SJ (author)
  • Eller, LA (author)
  • Sajjaweerawan, C (author)
  • Pagliuzza, A (author)
  • Chomont, N (author)
  • Rerknimitr, R (author)
  • Chomchey, N (author)
  • Phanuphak, N (author)
  • de Souza, MS (author)
  • Michael, NL (author)
  • Robb, ML (author)
  • Ananworanich, J (author)
  • Sandberg, JKKarolinska Institutet (author)
  • Eller, MA (author)
  • Schuetz, A (author)
  • Karolinska Institutet (creator_code:org_t)

Related titles

  • In:Proceedings of the National Academy of Sciences of the United States of America: Proceedings of the National Academy of Sciences118:461091-6490
  • In:Proceedings of the National Academy of Sciences: Proceedings of the National Academy of Sciences118:460027-8424

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