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WFRF:(van der Werff S. J. A.)
 

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  • Hedberg, PKarolinska Institutet (author)

Clinical phenotypes and outcomes of SARS-CoV-2, influenza, RSV and seven other respiratory viruses: a retrospective study using complete hospital data

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • 2021-07-05
  • BMJ,2022

Numbers

  • LIBRIS-ID:oai:prod.swepub.kib.ki.se:148312939
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:148312939URI
  • https://doi.org/10.1136/thoraxjnl-2021-216949DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • An understanding of differences in clinical phenotypes and outcomes COVID-19 compared with other respiratory viral infections is important to optimise the management of patients and plan healthcare. Herein we sought to investigate such differences in patients positive for SARS-CoV-2 compared with influenza, respiratory syncytial virus (RSV) and other respiratory viruses.MethodsWe performed a retrospective cohort study of hospitalised adults and children (≤15 years) who tested positive for SARS-CoV-2, influenza virus A/B, RSV, rhinovirus, enterovirus, parainfluenza viruses, metapneumovirus, seasonal coronaviruses, adenovirus or bocavirus in a respiratory sample at admission between 2011 and 2020.ResultsA total of 6321 adult (1721 SARS-CoV-2) and 6379 paediatric (101 SARS-CoV-2) healthcare episodes were included in the study. In adults, SARS-CoV-2 positivity was independently associated with younger age, male sex, overweight/obesity, diabetes and hypertension, tachypnoea as well as better haemodynamic measurements, white cell count, platelet count and creatinine values. Furthermore, SARS-CoV-2 was associated with higher 30-day mortality as compared with influenza (adjusted HR (aHR) 4.43, 95% CI 3.51 to 5.59), RSV (aHR 3.81, 95% CI 2.72 to 5.34) and other respiratory viruses (aHR 3.46, 95% CI 2.61 to 4.60), as well as higher 90-day mortality, ICU admission, ICU mortality and pulmonary embolism in adults. In children, patients with SARS-CoV-2 were older and had lower prevalence of chronic cardiac and respiratory diseases compared with other viruses.ConclusionsSARS-CoV-2 is associated with more severe outcomes compared with other respiratory viruses, and although associated with specific patient and clinical characteristics at admission, a substantial overlap precludes discrimination based on these characteristics.

Added entries (persons, corporate bodies, meetings, titles ...)

  • Valik, JKKarolinska Institutet (author)
  • van der Werff, SKarolinska Institutet (author)
  • Tanushi, H (author)
  • Mendez, ARKarolinska Institutet (author)
  • Granath, FKarolinska Institutet (author)
  • Bell, MKarolinska Institutet (author)
  • Martensson, JKarolinska Institutet (author)
  • Dyrdak, RKarolinska Institutet (author)
  • Hertting, OKarolinska Institutet (author)
  • Farnert, AKarolinska Institutet (author)
  • Ternhag, AKarolinska Institutet (author)
  • Naucler, PKarolinska Institutet (author)
  • Karolinska Institutet (creator_code:org_t)

Related titles

  • In:Thorax: BMJ77:2, s. 154-1631468-32960040-6376

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