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Epigenome-wide meta...
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Jia, TYKings Coll London, Social Genet & Dev Psychiat Ctr, Inst Psychiat Psychol & Neurosci, London, England.;Fudan Univ, Inst Sci & Technol Brain Inspired Intelligence, Shanghai, Peoples R China.;Fudan Univ, MOE Key Lab Computat Neurosci & Brain Inspired In, Shanghai, Peoples R China.
(author)
Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group
- Article/chapterEnglish2021
Publisher, publication year, extent ...
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2019-12-06
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Springer Science and Business Media LLC,2021
Numbers
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:148639309
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http://kipublications.ki.se/Default.aspx?queryparsed=id:148639309URI
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https://doi.org/10.1038/s41380-019-0605-zDOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-466960URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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DNA methylation, which is modulated by both genetic factors and environmental exposures, may offer a unique opportunity to discover novel biomarkers of disease-related brain phenotypes, even when measured in other tissues than brain, such as blood. A few studies of small sample sizes have revealed associations between blood DNA methylation and neuropsychopathology, however, large-scale epigenome-wide association studies (EWAS) are needed to investigate the utility of DNA methylation profiling as a peripheral marker for the brain. Here, in an analysis of eleven international cohorts, totalling 3337 individuals, we report epigenome-wide meta-analyses of blood DNA methylation with volumes of the hippocampus, thalamus and nucleus accumbens (NAcc)—three subcortical regions selected for their associations with disease and heritability and volumetric variability. Analyses of individual CpGs revealed genome-wide significant associations with hippocampal volume at two loci. No significant associations were found for analyses of thalamus and nucleus accumbens volumes. Cluster-based analyses revealed additional differentially methylated regions (DMRs) associated with hippocampal volume. DNA methylation at these loci affected expression of proximal genes involved in learning and memory, stem cell maintenance and differentiation, fatty acid metabolism and type-2 diabetes. These DNA methylation marks, their interaction with genetic variants and their impact on gene expression offer new insights into the relationship between epigenetic variation and brain structure and may provide the basis for biomarker discovery in neurodegeneration and neuropsychiatric conditions.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Chu, CYKings Coll London, Social Genet & Dev Psychiat Ctr, Inst Psychiat Psychol & Neurosci, London, England.
(author)
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Liu, YFudan Univ, Zhongshan Hosp, Sch Basic Med Sci, Dept Biochem & Mol Biol,MOE Key Lab Metab & Mol M, Shanghai, Peoples R China.
(author)
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van Dongen, JVrije Univ Amsterdam, Dept Biol Psychol, Van der Boechorststr 1, NL-1081 BT Amsterdam, Netherlands.,Univ New South Wales, Ctr Hlth Brain Ageing, Sch Psychiat, Sydney, NSW, Australia.
(author)
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Papastergios, EKings Coll London, Social Genet & Dev Psychiat Ctr, Inst Psychiat Psychol & Neurosci, London, England.
(author)
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Armstrong, NJMurdoch Univ, Math & Stat, Perth, WA, Australia.,Univ Southern Calif, Keck Sch Med, Imaging Genet Ctr, Mark & Mary Stevens Neuroimaging & Informat Inst, Marina Del Rey, CA USA.
(author)
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Bastin, MEUniv Edinburgh MEB, Brain Res Imaging Ctr, Ctr Clin Brain Sci, Edinburgh, Midlothian, Scotland.;Univ Edinburgh MEB, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh, Midlothian, Scotland.
(author)
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Carrillo-Roa, TMax Planck Inst Psychiat, Dept Translat Res Psychiat, Kraepelinstr 2-10, D-80804 Munich, Germany.
(author)
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den Braber, AVrije Univ Amsterdam, Dept Biol Psychol, Van der Boechorststr 1, NL-1081 BT Amsterdam, Netherlands.
(author)
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Harris, MUniv Edinburgh, Ctr Clin Brain Sci, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Edinburgh Imaging, Edinburgh, Midlothian, Scotland.
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Jansen, RVrije Univ Amsterdam Med Ctr, Dept Psychiat, Amsterdam, Netherlands.
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Liu, JYUniv New Mexico, Dept Elect Engn, Albuquerque, NM 87131 USA.
(author)
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Luciano, MUniv Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Dept Psychol, Edinburgh, Midlothian, Scotland.,Queensland Univ Technol, Sch Clin Sci, Herston Imaging Res Facil, Brisbane, Qld, Australia.
(author)
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Ori, APSUniv Calif Los Angeles, UCLA Ctr Neurobehav Genet, Los Angeles, CA USA.,Univ New South Wales, Ctr Hlth Brain Ageing, Sch Psychiat, Sydney, NSW, Australia.;Prince Wales Hosp, Neuropsychiat Inst, Sydney, NSW, Australia.,Indiana Univ Sch Med, Radiol & Imaging Sci, Indianapolis, IN 46202 USA.
(author)
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Santianez, RRUniv Cantabria, Univ Hosp Marques de Valdecilla, Sch Med, Dept Psychiat, Santander, Spain.;Ctr Invest Biomed Red Salud Mental, Santander, Spain.
(author)
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Ruggeri, BKings Coll London, Social Genet & Dev Psychiat Ctr, Inst Psychiat Psychol & Neurosci, London, England.
(author)
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Sarkisyan, DaniilUppsala universitet,Institutionen för farmaceutisk biovetenskap(Swepub:uu)dansa302
(author)
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Shin, JUniv Toronto, Hosp Sick Children, Toronto, ON, Canada.
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Sungeun, KIndiana Univ Sch Med, Ctr Neuroimaging, Dept Radiol & Imaging Sci, Indianapolis, IN 46202 USA.;Indiana Univ Sch Med, Ctr Computat Biol & Bioinformat, Indianapolis, IN 46202 USA.
(author)
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Gutierrez, DTUniv Cantabria, Univ Hosp Marques de Valdecilla, Sch Med, Dept Psychiat, Santander, Spain.;Valdecilla Biomed Res Inst IDIVAL, Neuroimaging Unit, Technol Facil, Santander, Cantabria, Spain.
(author)
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van't Ent, DVrije Univ Amsterdam, Dept Biol Psychol, Van der Boechorststr 1, NL-1081 BT Amsterdam, Netherlands.
(author)
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Ames, DNatl Ageing Res Inst, Parkville, Vic, Australia.;Univ Melbourne, Acad Unit Psychiat Old Age, St Georges Hosp, Kew, Vic, Australia.
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Artiges, EUniv Paris 05, Inst Natl Sante & Rech Med, INSERM Unit 1000 Neuroimaging & Psychiat, Univ Paris Sud Paris Saclay, Orsay, France.;DIGITEO Labs, Gif Sur Yvette, France.;GH Nord Essonne Psychiat Dept 91G16, Orsay, France.
(author)
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Bakalkin, GeorgyUppsala universitet,Institutionen för farmaceutisk biovetenskap(Swepub:uu)gueba200
(author)
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Banaschewski, THeidelberg Univ, Dept Child & Adolescent Psychiat & Psychotherapy, Cent Inst Mental Hlth, Med Fac Mannheim, Sq J5, D-68159 Mannheim, Germany.
(author)
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Bokde, ALWTrinity Coll Dublin, Sch Med, Discipline Psychiat, Dublin, Ireland.;Trinity Coll Dublin, Trinity Inst Neurosci, Dublin, Ireland.,Univ New South Wales, Ctr Hlth Brain Ageing, Sch Psychiat, Sydney, NSW, Australia.
(author)
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Brodaty, HUniv New South Wales, Ctr Hlth Brain Ageing, Sch Psychiat, Sydney, NSW, Australia.;Univ New South Wales, Dementia Ctr Res Collaborat, Sch OfPsychiat, Sydney, NSW, Australia.
(author)
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Bromberg, UUniv Med Ctr Hamburg Eppendorf, House W34,3 OG,Martinistr 52, D-3 Hamburg, Germany.
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Brouwer, RUniv Med Ctr Utrecht, Dept Psychiat, Utrecht, Netherlands.;Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Utrecht, Netherlands.
(author)
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Buchel, CUniv Med Ctr Hamburg Eppendorf, House W34,3 OG,Martinistr 52, D-3 Hamburg, Germany.
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Quinlan, EBKings Coll London, Social Genet & Dev Psychiat Ctr, Inst Psychiat Psychol & Neurosci, London, England.
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Cahn, WUniv Med Ctr Utrecht, Dept Psychiat, Utrecht, Netherlands.;Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Utrecht, Netherlands.
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de Zubicaray, GIQueensland Univ Technol, Fac Hlth, Inst Hlth & Biomed Innovat, Brisbane, Qld, Australia.
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Ehrlich, STech Univ Dresden, Div Psychol & Social Med & Dev Neurosci, Fac Med, Dresden, Germany.
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Ekstrom, TJKarolinska Institutet,Karolinska Univ Hosp, Ctr Mol Med, Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden.,Univ Calif Los Angeles, UCLA Ctr Neurobehav Genet, Los Angeles, CA USA.;Univ Med Ctr Utrecht, Dept Psychiat, Utrecht, Netherlands.;Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Utrecht, Netherlands.,Univ New South Wales, Ctr Hlth Brain Ageing, Sch Psychiat, Sydney, NSW, Australia.;Univ New South Wales, Sch Psychiat, Dept Dev Disabil Neuropsychiat, Sydney, NSW, Australia.
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Flor, HHeidelberg Univ, Med Fac Mannheim, CentralInst Mental Hlth, Dept Cognit & Clin Neurosci, Sq J5, Mannheim, Germany.;Univ Mannheim, Sch Social Sci, Dept Psychol, D-68131 Mannheim, Germany.
(author)
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Frohner, JHTech Univ Dresden, Dept Psychiat, Dresden, Germany.;Tech Univ Dresden, Neuroimaging Ctr, Dresden, Germany.,Univ Cape Town, Dept Psychiat, Cape Town, South Africa.;Univ Cape Town, Neurosci Inst, Cape Town, South Africa.
(author)
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Frouin, VUniv Paris Saclay, NeuroSpin, CEA, F-91191 Gif Sur Yvette, France.
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Garavan, HUniv Vermont, Dept Psychiat, Burlington, VT 05405 USA.
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Gowland, PUniv Nottingham, Sir Peter Mansfield Imaging Ctr, Sch Phys & Astron, Univ Pk, Nottingham, England.,Max Planck Inst Psychiat, Dept Translat Res Psychiat, Kraepelinstr 2-10, D-80804 Munich, Germany.
(author)
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Heinz, ACharite Univ Med Berlin, Freie Univ Berlin, Humboldt Univ Berlin, Berlin, Germany.;Berlin Inst Hlth, Dept Psychiat & Psychotherapy, Campus Charite Mitte, Charitepl 1, Berlin, Germany.
(author)
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Hoare, J
(author)
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Ittermann, BPhys Tech Bundesanstalt PTB, Berlin, Germany.,Vrije Univ Amsterdam, Dept Biol Psychol, Van der Boechorststr 1, NL-1081 BT Amsterdam, Netherlands.
(author)
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Jahanshad, N
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Jiang, JY
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Kwok, JBUniv Sydney, Cent Clin Sch, Brain & Mind Ctr, Camperdown, NSW 2050, Australia.;Univ New South Wales, Sch Med Sci, Sydney, NSW, Australia.
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Martin, NGQIMR Berghofer Med Res Inst, Genet Epidemiol, Brisbane, Qld, Australia.
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Martinot, JLUniv Paris 05, Inst Natl Sante & Rech Med, INSERM Unit 1000 Neuroimaging & Psychiat, Univ Paris Sud Paris Saclay, Orsay, France.;DIGITEO Labs, Gif Sur Yvette, France.;Cochin Hosp, Maison Solenn, Paris, France.
(author)
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Mather, KAUniv New South Wales, Ctr Hlth Brain Ageing, Sch Psychiat, Sydney, NSW, Australia.;Neurosci Res Australia, Sydney, NSW, Australia.
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McMahon, KL
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McRae, AFUniv Queensland, Inst Mol Biosci, Brisbane, Qld, Australia.
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Nees, FHeidelberg Univ, Dept Child & Adolescent Psychiat & Psychotherapy, Cent Inst Mental Hlth, Med Fac Mannheim, Sq J5, D-68159 Mannheim, Germany.;Heidelberg Univ, Med Fac Mannheim, CentralInst Mental Hlth, Dept Cognit & Clin Neurosci, Sq J5, Mannheim, Germany.
(author)
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Orfanos, DPUniv Paris Saclay, NeuroSpin, CEA, F-91191 Gif Sur Yvette, France.
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Paus, TUniv Toronto, Bloorview Res Inst, Holland Bloorview Kids Rehabil Hosp, Toronto, ON M6A 2E1, Canada.;Univ Toronto, Dept Psychol, Toronto, ON M6A 2E1, Canada.;Univ Toronto, Dept Psychiat, Toronto, ON M6A 2E1, Canada.,Univ Southern Calif, Keck Sch Med, Imaging Genet Ctr, Mark & Mary Stevens Neuroimaging & Informat Inst, Marina Del Rey, CA USA.
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Poustka, LUniv Med Ctr Gottingen, Dept Child & Adolescent Psychiat & Psychotherapy, von Siebold Str 5, D-37075 Gottingen, Germany.
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Samann, PG
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Schofield, PRNeurosci Res Australia, Sydney, NSW, Australia.;Univ New South Wales, Fac Med, Sydney, NSW, Australia.
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Smolka, MNTech Univ Dresden, Dept Psychiat, Dresden, Germany.;Tech Univ Dresden, Neuroimaging Ctr, Dresden, Germany.
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Stein, DJUniv Cape Town, Dept Psychiat, Cape Town, South Africa.;Univ Cape Town, Neurosci Inst, Cape Town, South Africa.;SAMRC Unit Risk & Resilience Mental Disorders, Cape Town, South Africa.
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Strike, LTUniv Queensland, Queensland Brain Inst, Brisbane, Qld, Australia.
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Teeuw, J
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Thalamuthu, AUniv New South Wales, Ctr Hlth Brain Ageing, Sch Psychiat, Sydney, NSW, Australia.;Neurosci Res Australia, Sydney, NSW, Australia.
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Trollor, J
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Walter, HCharite Univ Med Berlin, Freie Univ Berlin, Humboldt Univ Berlin, Berlin, Germany.;Berlin Inst Hlth, Dept Psychiat & Psychotherapy, Campus Charite Mitte, Charitepl 1, Berlin, Germany.
(author)
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Wardlaw, JMUniv Edinburgh, Brain Res Imaging Ctr, Ctr Clin Brain Sci, Edinburgh Dementia Res Ctr, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, UK Dementia Res Inst, Edinburgh, Midlothian, Scotland.
(author)
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Wen, W
(author)
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Whelan, RTrinity Coll Dublin, Sch Psychol, Dublin, Ireland.;Trinity Coll Dublin, Global Brain Hlth Inst, Dublin, Ireland.
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Apostolova, LGIndiana Univ Sch Med, Dept Neurol, Indianapolis, IN 46202 USA.;Indiana Univ Sch Med, Dept Radiol & Imaging Sci, Indianapolis, IN 46202 USA.;Indiana Univ Sch Med, Dept Med & Mol Genet, Indianapolis, IN 46202 USA.;Indiana Univ Sch Med, Indiana Alzheimer Dis Ctr, Indianapolis, IN 46202 USA.
(author)
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Binder, EBMax Planck Inst Psychiat, Dept Translat Res Psychiat, Kraepelinstr 2-10, D-80804 Munich, Germany.
(author)
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Boomsma, DI
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Calhoun, VUniv New Mexico, Dept Elect Engn, Albuquerque, NM 87131 USA.;Emory Univ, Triinst Ctr Translat Res Neuroimaging & Data Sci, Atlanta, GA 30303 USA.
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Crespo-Facorro, BUniv Cantabria, Univ Hosp Marques de Valdecilla, Sch Med, Dept Psychiat, Santander, Spain.
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Deary, IJUniv Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Dept Psychol, Edinburgh, Midlothian, Scotland.
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Pol, HHUniv Med Ctr Utrecht, Dept Psychiat, Utrecht, Netherlands.;Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Utrecht, Netherlands.
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Ophoff, RAUniv Med Ctr Utrecht, Dept Psychiat, Utrecht, Netherlands.;Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Utrecht, Netherlands.;Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, Los Angeles, CA 90024 USA.
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Pausova, ZUniv Toronto, Hosp Sick Children, Toronto, ON, Canada.
(author)
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Sachdev, PS
(author)
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Saykin, A
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Wright, MJQIMR Berghofer Med Res Inst, Genet Epidemiol, Brisbane, Qld, Australia.
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Thompson, PM
(author)
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Schumann, GKings Coll London, Social Genet & Dev Psychiat Ctr, Inst Psychiat Psychol & Neurosci, London, England.
(author)
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Desrivieres, SKings Coll London, Social Genet & Dev Psychiat Ctr, Inst Psychiat Psychol & Neurosci, London, England.
(author)
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Kings Coll London, Social Genet & Dev Psychiat Ctr, Inst Psychiat Psychol & Neurosci, London, England.;Fudan Univ, Inst Sci & Technol Brain Inspired Intelligence, Shanghai, Peoples R China.;Fudan Univ, MOE Key Lab Computat Neurosci & Brain Inspired In, Shanghai, Peoples R China.Kings Coll London, Social Genet & Dev Psychiat Ctr, Inst Psychiat Psychol & Neurosci, London, England.
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In:Molecular psychiatry: Springer Science and Business Media LLC26:8, s. 3884-38951476-55781359-4184
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- By the author/editor
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Jia, TY
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Chu, CY
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Liu, Y
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van Dongen, J
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Papastergios, E
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Armstrong, NJ
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show more...
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Bastin, ME
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Carrillo-Roa, T
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den Braber, A
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Harris, M
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Jansen, R
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Liu, JY
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Luciano, M
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Ori, APS
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Santianez, RR
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Ruggeri, B
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Sarkisyan, Danii ...
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Shin, J
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Sungeun, K
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Gutierrez, DT
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van't Ent, D
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Ames, D
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Artiges, E
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Bakalkin, Georgy
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Banaschewski, T
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Bokde, ALW
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Brodaty, H
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Bromberg, U
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Brouwer, R
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Buchel, C
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Quinlan, EB
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Cahn, W
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de Zubicaray, GI
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Ehrlich, S
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Ekstrom, TJ
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Flor, H
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Frohner, JH
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Frouin, V
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Garavan, H
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Gowland, P
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Heinz, A
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Hoare, J
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Ittermann, B
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Jahanshad, N
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Jiang, JY
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Kwok, JB
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Martin, NG
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Martinot, JL
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Mather, KA
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McMahon, KL
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McRae, AF
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Nees, F
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Orfanos, DP
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Paus, T
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Poustka, L
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Samann, PG
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Schofield, PR
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Smolka, MN
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Stein, DJ
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Strike, LT
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Teeuw, J
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Thalamuthu, A
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Trollor, J
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Walter, H
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Wardlaw, JM
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Wen, W
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Whelan, R
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Apostolova, LG
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Binder, EB
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Boomsma, DI
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Calhoun, V
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Crespo-Facorro, ...
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Deary, IJ
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Pol, HH
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Ophoff, RA
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Pausova, Z
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Sachdev, PS
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Saykin, A
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Wright, MJ
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Thompson, PM
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Schumann, G
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Desrivieres, S
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Molecular psychi ...
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