Molecular, behavioral, and growth responses of juvenile yellow catfish ( Tachysurus fulvidraco ) exposed to carbamazepine

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Chen, HuihuiUppsala universitet,Institutionen för organismbiologi,Chinese Acad Sci, Nanjing Inst Geog & Limnol, State Key Lab Lake Sci & Environm, 73 East Beijing Rd, Nanjing 210008, Jiangsu, Peoples R China. (författare)

Molecular, behavioral, and growth responses of juvenile yellow catfish ( Tachysurus fulvidraco ) exposed to carbamazepine

Artikel/kapitelEngelska2024

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Elsevier,2024
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LIBRIS-ID:oai:DiVA.org:uu-531107
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-531107URI
https://doi.org/10.1016/j.aquatox.2024.106929DOI

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Språk:engelska
Sammanfattning på:engelska

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Carbamazepine (CBZ) is an anticonvulsant medication used to treat epilepsy and bipolar disorder. Due to its persistence and low removal rate in wastewater treatment plants, it is frequently detected in the environment, raising concerns regarding its potential adverse effects on aquatic organisms and ecosystems. In this study, we aimed to assess the impact of CBZ on the behavior and growth of juvenile yellow catfish Tachysurus fulvidraco , a native and economically important species in China. Fish were exposed to CBZ at three concentrations of 1, 10, or 100 mu g/L for 14 days. The fish exposed to 10 and 100 mu g/L of CBZ exhibited decreased feeding, and a significant increase in cannibalistic tendencies was observed in fish exposed to 100 mu g/L CBZ. Acetylcholinesterase activity was increased in the brain of fish exposed to 100 mu g/L CBZ. CBZ also inhibited the growth of yellow catfish. To better elucidate mechanisms of toxicity, transcriptomics was conducted in both the brain and liver. In the brain, gene networks associated with neurotransmitter dysfunction were altered by CBZ, as well as networks associated with mitochondrial dysfunction and metabolism. In the liver, gene networks associated with the immune system were altered by CBZ. The current study improves comprehension of the sub-lethal effects of CBZ and reveals novel insight into molecular and biochemical pathways disrupted by CBZ, identifying putative key events associated with reduced growth and altered behavior. This study emphasizes the necessity for improved comprehension of the effects of pharmaceutical contaminants on fish at environmentally relevant levels.

Ämnesord och genrebeteckningar

NATURVETENSKAP Geovetenskap och miljövetenskap Miljövetenskap hsv//swe
NATURAL SCIENCES Earth and Related Environmental Sciences Environmental Sciences hsv//eng
Pharmaceuticals
Food consumption
Growth
Cannibalism
RNA-seq
Mechanisms

Biuppslag (personer, institutioner, konferenser, titlar ...)

Gu, XiaohongChinese Acad Sci, Nanjing Inst Geog & Limnol, State Key Lab Lake Sci & Environm, 73 East Beijing Rd, Nanjing 210008, Jiangsu, Peoples R China.;Huaiyin Normal Univ, Jiangsu Collaborat Innovat Ctr Reg Modern Agr & En, Huaian 223300, Peoples R China. (författare)
Mao, ZhigangChinese Acad Sci, Nanjing Inst Geog & Limnol, State Key Lab Lake Sci & Environm, 73 East Beijing Rd, Nanjing 210008, Jiangsu, Peoples R China. (författare)
Zeng, QingfeiChinese Acad Sci, Nanjing Inst Geog & Limnol, State Key Lab Lake Sci & Environm, 73 East Beijing Rd, Nanjing 210008, Jiangsu, Peoples R China. (författare)
Jin, MiaoChinese Acad Sci, Nanjing Inst Geog & Limnol, State Key Lab Lake Sci & Environm, 73 East Beijing Rd, Nanjing 210008, Jiangsu, Peoples R China. (författare)
Wang, WenxiaChinese Acad Sci, Nanjing Inst Geog & Limnol, State Key Lab Lake Sci & Environm, 73 East Beijing Rd, Nanjing 210008, Jiangsu, Peoples R China.;Linyi Univ, Coll Life Sci, Linyi 276000, Peoples R China. (författare)
Martyniuk, Christopher J.Univ Florida, Genet Inst, Coll Vet Med, Dept Physiol Sci,Interdisciplinary Program Biomed, Gainesville, FL 32611 USA.;Univ Florida, Genet Inst, Ctr Environm & Human Toxicol, Coll Vet Med,Interdisciplinary Program Biomed Sci, Gainesville, FL 32611 USA. (författare)
Uppsala universitetInstitutionen för organismbiologi (creator_code:org_t)

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Ingår i:Aquatic Toxicology: Elsevier2710166-445X1879-1514

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Av författaren/redakt...: Chen, Huihui; Gu, Xiaohong; Mao, Zhigang; Zeng, Qingfei; Jin, Miao; Wang, Wenxia; visa fler...; Martyniuk, Chris ...; visa färre...

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