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New insights into t...
New insights into the genetic etiology of Alzheimer's disease and related dementias
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- Bellenguez, C (author)
- Univ Lille, Facteurs Risque & Terminants Mol Malad Liees Viei, Inst Pasteur Lille, INSERM,U1167 RID AGE,CHU Lille, Lille, France
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Kucukali, F (author)
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Jansen, IE (author)
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show more...
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Kleineidam, L (author)
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Moreno-Grau, S (author)
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Amin, N (author)
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Naj, AC (author)
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Campos-Martin, R (author)
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Grenier-Boley, B (author)
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Andrade, V (author)
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Holmans, PA (author)
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Boland, A (author)
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Damotte, V (author)
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van der Lee, SJ (author)
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Costa, MR (author)
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Kuulasmaa, T (author)
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Yang, Q (author)
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De Rojas, I (author)
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- Bis, JC (author)
- Karolinska Institutet
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Yaqub, A (author)
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Prokic, I (author)
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Chapuis, J (author)
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- Ahmad, S (author)
- Karolinska Institutet
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- Giedraitis, Vilmantas (author)
- Uppsala universitet,Geriatrik
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- Aarsland, D (author)
- Karolinska Institutet
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- Garcia-Gonzalez, P (author)
- Karolinska Institutet
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Abdelnour, C (author)
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Alarcon-Martin, E (author)
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Alcolea, D (author)
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Alegret, M (author)
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Alvarez, I (author)
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Alvarez, V (author)
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Armstrong, NJ (author)
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Tsolaki, A (author)
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Antunez, C (author)
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Appollonio, I (author)
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Arcaro, M (author)
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Archetti, S (author)
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Pastor, AA (author)
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Arosio, B (author)
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Athanasiu, L (author)
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Bailly, H (author)
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Banaj, N (author)
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Baquero, M (author)
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Barral, S (author)
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Beiser, A (author)
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Pastor, AB (author)
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Below, JE (author)
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Benchek, P (author)
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Benussi, L (author)
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Berr, C (author)
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Besse, C (author)
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Bessi, V (author)
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Binetti, G (author)
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Bizarro, A (author)
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Blesa, R (author)
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Boada, M (author)
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Boerwinkle, E (author)
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Borroni, B (author)
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Boschi, S (author)
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Bossu, P (author)
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Brathen, G (author)
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Bressler, J (author)
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Bresner, C (author)
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Brodaty, H (author)
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Brookes, KJ (author)
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Brusco, LI (author)
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Buiza-Rueda, D (author)
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Burger, K (author)
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Burholt, V (author)
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Bush, WS (author)
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Calero, M (author)
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Cantwell, LB (author)
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- Chene, G (author)
- Karolinska Institutet
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Chung, J (author)
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Cuccaro, ML (author)
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Cecchetti, R (author)
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Cervera-Carles, L (author)
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Charbonnier, C (author)
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Chen, HH (author)
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Chillotti, C (author)
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Ciccone, S (author)
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Claassen, JAHR (author)
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Clark, C (author)
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Conti, E (author)
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Corma-Gomez, A (author)
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Costantini, E (author)
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Custodero, C (author)
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Daian, D (author)
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Dalmasso, MC (author)
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Daniele, A (author)
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Dardiotis, E (author)
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Dartigues, JF (author)
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de Deyn, PP (author)
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Lopes, KD (author)
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De Witte, LD (author)
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Debette, S (author)
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Deckert, J (author)
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del Ser, T (author)
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Denning, N (author)
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Destefano, A (author)
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Dichgans, M (author)
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Diehl-Schmid, J (author)
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- Diez-Fairen, M (author)
- Karolinska Institutet
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Rossi, PD (author)
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Djurovic, S (author)
-
Duron, E (author)
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Duzel, E (author)
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Dufouil, C (author)
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Eiriksdottir, G (author)
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Engelborghs, S (author)
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Escott-Price, V (author)
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Espinosa, A (author)
-
Ewers, M (author)
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- Faber, KM (author)
- Karolinska Institutet
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Fabrizio, T (author)
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Nielsen, SF (author)
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Fardo, DW (author)
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Farotti, L (author)
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Fenoglio, C (author)
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Fernandez-Fuertes, M (author)
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Ferrari, R (author)
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Ferreira, CB (author)
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Ferri, E (author)
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Fin, B (author)
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Fischer, P (author)
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Fladby, T (author)
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Fliessbach, K (author)
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Fongang, B (author)
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Fornage, M (author)
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Fortea, J (author)
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Foroud, TM (author)
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Fostinelli, S (author)
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Fox, NC (author)
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Franco-Macias, E (author)
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Bullido, MJ (author)
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Frank-Garcia, A (author)
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Froelich, L (author)
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Fulton-Howard, B (author)
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Galimberti, D (author)
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Garcia-Alberca, JM (author)
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Garcia-Madrona, S (author)
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- Garcia-Ribas, G (author)
- Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)
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Ghidoni, R (author)
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Giegling, I (author)
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Giorgio, G (author)
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Goate, AM (author)
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Goldhardt, O (author)
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Gomez-Fonseca, D (author)
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Gonzalez-Perez, A (author)
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- Graff, C (author)
- Karolinska Institutet
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- Grande, G (author)
- Karolinska Institutet
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Green, E (author)
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Grimmer, T (author)
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Grunblatt, E (author)
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Grunin, M (author)
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Gudnason, V (author)
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Guetta-Baranes, T (author)
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Haapasalo, A (author)
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Hadjigeorgiou, G (author)
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Haines, JL (author)
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Hamilton-Nelson, KL (author)
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Hampel, H (author)
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Hanon, O (author)
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Hardy, J (author)
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Hartmann, AM (author)
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Hausner, L (author)
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Harwood, J (author)
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Heilmann-Heimbach, S (author)
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Helisalmi, S (author)
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Heneka, MT (author)
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Hernandez, I (author)
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Herrmann, MJ (author)
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Hoffmann, P (author)
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Holmes, C (author)
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Holstege, H (author)
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Vilas, RH (author)
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Hulsman, M (author)
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Humphrey, J (author)
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Biessels, GJ (author)
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Jian, XQ (author)
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- Johansson, C (author)
- Karolinska Institutet
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Jun, GR (author)
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Kastumata, Y (author)
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Kauwe, J (author)
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- Kehoe, PG (author)
- Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)
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Kilander, L (author)
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Stahlbom, AK (author)
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- Kivipelto, M (author)
- Karolinska Institutet
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Koivisto, A (author)
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Kornhuber, J (author)
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Kosmidis, MH (author)
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Kukull, WA (author)
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Kuksa, PP (author)
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Kunkle, BW (author)
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Kuzma, AB (author)
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Lage, C (author)
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- Laukka, EJ (author)
- Stockholms universitet,Karolinska Institutet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Stockholm Gerontology Research Center, Sweden
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Launer, L (author)
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Lauria, A (author)
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Lee, CY (author)
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Lehtisalo, J (author)
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Lerch, O (author)
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Lleo, A (author)
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Longstreth, W (author)
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Lopez, O (author)
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de Munain, AL (author)
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Love, S (author)
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Lowemark, M (author)
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Luckcuck, L (author)
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Lunetta, KL (author)
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Ma, YY (author)
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Macias, J (author)
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Macleod, CA (author)
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Maier, W (author)
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- Mangialasche, F (author)
- Karolinska Institutet
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Spallazzi, M (author)
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Marquie, M (author)
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Marshall, R (author)
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Martin, ER (author)
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Montes, AM (author)
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Rodriguez, CM (author)
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Masullo, C (author)
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Mayeux, R (author)
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Mead, S (author)
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- Mecocci, P (author)
- Karolinska Institutet
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Medina, M (author)
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Meggy, A (author)
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Mehrabian, S (author)
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Mendoza, S (author)
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Menendez-Gonzalez, M (author)
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Mir, P (author)
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Moebus, S (author)
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Mol, M (author)
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Molina-Porcel, L (author)
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Montrreal, L (author)
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Morelli, L (author)
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Moreno, F (author)
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Morgan, K (author)
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Mosley, T (author)
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Nothen, MM (author)
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Muchnik, C (author)
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Mukherjee, S (author)
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Nacmias, B (author)
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- Ngandu, T (author)
- Karolinska Institutet
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Nicolas, G (author)
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Nordestgaard, BG (author)
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Olaso, R (author)
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Orellana, A (author)
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Orsini, M (author)
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Ortega, G (author)
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Padovani, A (author)
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Paolo, C (author)
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- Papenberg, G (author)
- Karolinska Institutet
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Parnetti, L (author)
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Pasquier, F (author)
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Pastor, P (author)
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Peloso, G (author)
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Perez-Cordon, A (author)
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Perez-Tur, J (author)
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Pericard, P (author)
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Peters, O (author)
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Pijnenburg, YAL (author)
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Pineda, JA (author)
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Pinol-Ripoll, G (author)
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Pisanu, L (author)
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Polak, T (author)
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Popp, J (author)
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Posthuma, D (author)
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Priller, J (author)
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Puerta, R (author)
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Quenez, O (author)
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Quintela, I (author)
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Thomassen, JQ (author)
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Rabano, A (author)
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Rainero, I (author)
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Rajabli, F (author)
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Ramakers, I (author)
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Real, LM (author)
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Reinders, MJT (author)
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Reitz, C (author)
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Reyes-Dumeyer, D (author)
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Ridge, P (author)
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Riedel-Heller, S (author)
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Riederer, P (author)
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Roberto, N (author)
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Rodriguez-Rodriguez, E (author)
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Rongve, A (author)
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Allende, IR (author)
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Rosende-Roca, M (author)
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Royo, JL (author)
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Rubino, E (author)
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Rujescu, D (author)
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Saez, ME (author)
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Sakka, P (author)
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Saltvedt, I (author)
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Sanchez-Arjona, MB (author)
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Sanchez-Garcia, F (author)
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Juan, PS (author)
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Sanchez-Valle, R (author)
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Sando, SB (author)
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Sarnowski, C (author)
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Satizabal, CL (author)
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Scamosci, M (author)
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Scarmeas, N (author)
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Scarpini, E (author)
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Scheltens, P (author)
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Scherbaum, N (author)
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Scherer, M (author)
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Schmid, M (author)
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Schneider, A (author)
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Schott, JM (author)
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Selbaek, G (author)
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Seripa, D (author)
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Serrano, M (author)
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Sha, J (author)
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Shadrin, AA (author)
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Skrobot, O (author)
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Slifer, S (author)
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Snijders, GJL (author)
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Soininen, H (author)
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Solfrizzi, V (author)
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- Solomon, A (author)
- Karolinska Institutet
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Song, Y (author)
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Sorbi, S (author)
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Sotolongo-Grau, O (author)
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Spalletta, G (author)
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Spottke, A (author)
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Squassina, A (author)
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Stordal, E (author)
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Tartan, JP (author)
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Tarraga, L (author)
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Tesi, N (author)
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Thalamuthu, A (author)
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Thomas, T (author)
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Tosto, G (author)
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Traykov, L (author)
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Tremolizzo, L (author)
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Tybjaeg-Hansen, A (author)
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Uitterlinden, A (author)
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- Karolinska Institutet
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Ulstein, I (author)
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Valero, S (author)
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Valladares, O (author)
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Van Broeckhoven, C (author)
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Vance, J (author)
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Vardarajan, BN (author)
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van der Lugt, A (author)
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Van Dongen, J (author)
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van Rooij, J (author)
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van Swieten, J (author)
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Vandenberghe, R (author)
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Verhey, F (author)
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Vidal, JS (author)
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Vogelgsang, J (author)
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Vyhnalek, M (author)
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Wagner, M (author)
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Wallon, D (author)
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Wang, LS (author)
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Wang, RQ (author)
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Windle, G (author)
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Woods, B (author)
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Yannakoulia, M (author)
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Zare, H (author)
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Zhao, Y (author)
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Zhang, XL (author)
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Zhu, CC (author)
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Zulaica, M (author)
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Farrer, LA (author)
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Psaty, BM (author)
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Ghanbari, M (author)
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Raj, T (author)
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Sachdev, P (author)
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Mather, K (author)
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Jessen, F (author)
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Ikram, MA (author)
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de Mendonca, A (author)
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Hort, J (author)
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Tsolaki, M (author)
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Pericak-Vance, MA (author)
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Amouyel, P (author)
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Williams, J (author)
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Frikke-Schmidt, R (author)
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Clarimon, J (author)
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Deleuze, JF (author)
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Rossi, G (author)
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Seshadri, S (author)
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Andreassen, OA (author)
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- Ingelsson, Martin (author)
- Uppsala universitet,Geriatrik
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Hiltunen, M (author)
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Sleegers, K (author)
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Schellenberg, GD (author)
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van Duijn, CM (author)
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Sims, R (author)
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van der Flier, WM (author)
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Ruiz, A (author)
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Ramirez, A (author)
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- Lambert, JC (author)
- Univ Lille, Facteurs Risque & Terminants Mol Malad Liees Viei, Inst Pasteur Lille, INSERM,U1167 RID AGE,CHU Lille, Lille, France
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(creator_code:org_t)
- 2022-04-04
- 2022
- English.
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In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 54:4, s. 412-436
- Related links:
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https://doi.org/10.1...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
Close
- Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Bellenguez, C
-
Kucukali, F
-
Jansen, IE
-
Kleineidam, L
-
Moreno-Grau, S
-
Amin, N
-
show more...
-
Naj, AC
-
Campos-Martin, R
-
Grenier-Boley, B
-
Andrade, V
-
Holmans, PA
-
Boland, A
-
Damotte, V
-
van der Lee, SJ
-
Costa, MR
-
Kuulasmaa, T
-
Yang, Q
-
De Rojas, I
-
Bis, JC
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Yaqub, A
-
Prokic, I
-
Chapuis, J
-
Ahmad, S
-
Giedraitis, Vilm ...
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Aarsland, D
-
Garcia-Gonzalez, ...
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Abdelnour, C
-
Alarcon-Martin, ...
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Alcolea, D
-
Alegret, M
-
Alvarez, I
-
Alvarez, V
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Armstrong, NJ
-
Tsolaki, A
-
Antunez, C
-
Appollonio, I
-
Arcaro, M
-
Archetti, S
-
Pastor, AA
-
Arosio, B
-
Athanasiu, L
-
Bailly, H
-
Banaj, N
-
Baquero, M
-
Barral, S
-
Beiser, A
-
Pastor, AB
-
Below, JE
-
Benchek, P
-
Benussi, L
-
Berr, C
-
Besse, C
-
Bessi, V
-
Binetti, G
-
Bizarro, A
-
Blesa, R
-
Boada, M
-
Boerwinkle, E
-
Borroni, B
-
Boschi, S
-
Bossu, P
-
Brathen, G
-
Bressler, J
-
Bresner, C
-
Brodaty, H
-
Brookes, KJ
-
Brusco, LI
-
Buiza-Rueda, D
-
Burger, K
-
Burholt, V
-
Bush, WS
-
Calero, M
-
Cantwell, LB
-
Chene, G
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Chung, J
-
Cuccaro, ML
-
Cecchetti, R
-
Cervera-Carles, ...
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Charbonnier, C
-
Chen, HH
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Chillotti, C
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Ciccone, S
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Claassen, JAHR
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Clark, C
-
Conti, E
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Corma-Gomez, A
-
Costantini, E
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Custodero, C
-
Daian, D
-
Dalmasso, MC
-
Daniele, A
-
Dardiotis, E
-
Dartigues, JF
-
de Deyn, PP
-
Lopes, KD
-
De Witte, LD
-
Debette, S
-
Deckert, J
-
del Ser, T
-
Denning, N
-
Destefano, A
-
Dichgans, M
-
Diehl-Schmid, J
-
Diez-Fairen, M
-
Rossi, PD
-
Djurovic, S
-
Duron, E
-
Duzel, E
-
Dufouil, C
-
Eiriksdottir, G
-
Engelborghs, S
-
Escott-Price, V
-
Espinosa, A
-
Ewers, M
-
Faber, KM
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Fabrizio, T
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Nielsen, SF
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Fardo, DW
-
Farotti, L
-
Fenoglio, C
-
Fernandez-Fuerte ...
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Ferrari, R
-
Ferreira, CB
-
Ferri, E
-
Fin, B
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Fischer, P
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Fladby, T
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Fliessbach, K
-
Fongang, B
-
Fornage, M
-
Fortea, J
-
Foroud, TM
-
Fostinelli, S
-
Fox, NC
-
Franco-Macias, E
-
Bullido, MJ
-
Frank-Garcia, A
-
Froelich, L
-
Fulton-Howard, B
-
Galimberti, D
-
Garcia-Alberca, ...
-
Garcia-Madrona, ...
-
Garcia-Ribas, G
-
Ghidoni, R
-
Giegling, I
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Giorgio, G
-
Goate, AM
-
Goldhardt, O
-
Gomez-Fonseca, D
-
Gonzalez-Perez, ...
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Graff, C
-
Grande, G
-
Green, E
-
Grimmer, T
-
Grunblatt, E
-
Grunin, M
-
Gudnason, V
-
Guetta-Baranes, ...
-
Haapasalo, A
-
Hadjigeorgiou, G
-
Haines, JL
-
Hamilton-Nelson, ...
-
Hampel, H
-
Hanon, O
-
Hardy, J
-
Hartmann, AM
-
Hausner, L
-
Harwood, J
-
Heilmann-Heimbac ...
-
Helisalmi, S
-
Heneka, MT
-
Hernandez, I
-
Herrmann, MJ
-
Hoffmann, P
-
Holmes, C
-
Holstege, H
-
Vilas, RH
-
Hulsman, M
-
Humphrey, J
-
Biessels, GJ
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Nature genetics
- By the university
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Karolinska Institutet
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Stockholm University
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Uppsala University