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MAIT cell compartme...
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Boulouis, CKarolinska Institutet
(author)
MAIT cell compartment characteristics are associated with the immune response magnitude to the BNT162b2 mRNA anti-SARS-CoV-2 vaccine
- Article/chapterEnglish2022
Publisher, publication year, extent ...
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2022-05-13
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Springer Science and Business Media LLC,2022
Numbers
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:149571252
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http://kipublications.ki.se/Default.aspx?queryparsed=id:149571252URI
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https://doi.org/10.1186/s10020-022-00484-7DOI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Mucosa-associated invariant T (MAIT) cells are unconventional T cells with innate-like capacity to rapidly respond to microbial infection via MR1-restricted antigen recognition. Emerging evidence indicate that they can also act as rapid sensors of viral infection via innate cytokine activation. However, their possible role in the immune response to mRNA vaccination is unknown. Here, we evaluated the involvement of MAIT cells in individuals vaccinated with the BNT162b2 mRNA SARS-CoV-2 vaccine. MAIT cell levels, phenotype and function in circulation were preserved and unperturbed through day 35 post-vaccination in healthy donor (HD) vaccinees, as well as people living with HIV (PLWH) or with primary immunodeficiency (PID). Unexpectedly, pre-vaccination and post-vaccination levels of MAIT cells correlated positively with the magnitude of the SARS-CoV-2 spike protein-specific CD4 T cell and antibody responses in the HD vaccinees. This pattern was largely preserved in the PID group, but less so in the PLWH group. Furthermore, in the HD vaccinees levels of MAIT cell activation and cytolytic potential correlated negatively to the adaptive antigen-specific immune responses. These findings indicate an unexpected association between MAIT cell compartment characteristics and the immune response magnitude to the BNT162b2 mRNA vaccine.
Added entries (persons, corporate bodies, meetings, titles ...)
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Kammann, TKarolinska Institutet
(author)
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Cuapio, A
(author)
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Parrot, T
(author)
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Gao, Y
(author)
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Mouchtaridi, E
(author)
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Wullimann, D
(author)
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Lange, J
(author)
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Chen, P
(author)
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Akber, M
(author)
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Ballesteros, OR
(author)
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Muvva, JR
(author)
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Smith, CIEKarolinska Institutet
(author)
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Vesterbacka, JKarolinska Institutet
(author)
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Kieri, OKarolinska Institutet
(author)
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Nowak, PKarolinska Institutet
(author)
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Bergman, PKarolinska Institutet
(author)
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Buggert, MKarolinska Institutet
(author)
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Ljunggren, HGKarolinska Institutet
(author)
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Aleman, SKarolinska Institutet
(author)
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Sandberg, JKKarolinska Institutet
(author)
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Karolinska Institutet
(creator_code:org_t)
Related titles
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In:Molecular medicine (Cambridge, Mass.): Springer Science and Business Media LLC28:1, s. 54-1528-36581076-1551
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To the university's database
- By the author/editor
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Boulouis, C
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Kammann, T
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Cuapio, A
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Parrot, T
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Gao, Y
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Mouchtaridi, E
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show more...
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Wullimann, D
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Lange, J
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Chen, P
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Akber, M
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Ballesteros, OR
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Muvva, JR
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Smith, CIE
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Vesterbacka, J
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Kieri, O
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Nowak, P
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Bergman, P
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Buggert, M
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Ljunggren, HG
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Aleman, S
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Sandberg, JK
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- Articles in the publication
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Molecular medici ...
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Karolinska Institutet