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Plasma proteins ele...
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Mikus, MSKarolinska Institutet,Dept of Protein Science, KTH Royal Institute of Technology, SciLifeLab, Stockholm, Sweden; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden,Dept of Thoracic Medicine, Medical School, University of Crete, Heraklion, Crete, Greece
(författare)
Plasma proteins elevated in severe asthma despite oral steroid use and unrelated to Type-2 inflammation
- Artikel/kapitelEngelska2022
Förlag, utgivningsår, omfång ...
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2021-11-04
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European Respiratory Society (ERS),2022
Nummerbeteckningar
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:149615290
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http://kipublications.ki.se/Default.aspx?queryparsed=id:149615290URI
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https://doi.org/10.1183/13993003.00142-2021DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-192784URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-313314URI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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QC 20220602
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Asthma phenotyping requires novel biomarker discovery.ObjectivesTo identify plasma biomarkers associated with asthma phenotypes by application of a new proteomic panel to samples from two well-characterised cohorts of severe (SA) and mild-to-moderate (MMA) asthmatics, COPD subjects and healthy controls (HCs).MethodsAn antibody-based array targeting 177 proteins predominantly involved in pathways relevant to inflammation, lipid metabolism, signal transduction and extracellular matrix was applied to plasma from 525 asthmatics and HCs in the U-BIOPRED cohort, and 142 subjects with asthma and COPD from the validation cohort BIOAIR. Effects of oral corticosteroids (OCS) were determined by a 2-week, placebo-controlled OCS trial in BIOAIR, and confirmed by relation to objective OCS measures in U-BIOPRED.ResultsIn U-BIOPRED, 110 proteins were significantly different, mostly elevated, in SA compared to MMA and HCs. 10 proteins were elevated in SA versus MMA in both U-BIOPRED and BIOAIR (alpha-1-antichymotrypsin, apolipoprotein-E, complement component 9, complement factor I, macrophage inflammatory protein-3, interleukin-6, sphingomyelin phosphodiesterase 3, TNF receptor superfamily member 11a, transforming growth factor-β and glutathione S-transferase). OCS treatment decreased most proteins, yet differences between SA and MMA remained following correction for OCS use. Consensus clustering of U-BIOPRED protein data yielded six clusters associated with asthma control, quality of life, blood neutrophils, high-sensitivity C-reactive protein and body mass index, but not Type-2 inflammatory biomarkers. The mast cell specific enzyme carboxypeptidase A3 was one major contributor to cluster differentiation.ConclusionsThe plasma proteomic panel revealed previously unexplored yet potentially useful Type-2-independent biomarkers and validated several proteins with established involvement in the pathophysiology of SA.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Kolmert, JKarolinska Institutet,Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden
(författare)
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Andersson, LIKarolinska Institutet,Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden
(författare)
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Ostling, JGothenburg, Sweden
(författare)
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Knowles, RGKnowles Consulting, Stevenage Bioscience Catalyst, Stevenage, United Kingdom
(författare)
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Gomez, CInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden
(författare)
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Ericsson, MDept of Laboratory Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden
(författare)
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Thorngren, JODept of Laboratory Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden
(författare)
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Khoonsari, PEDept of Biochemistry and Biophysics, National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Solna, Sweden
(författare)
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Dahlen, BKarolinska Institutet,Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden; Dept of Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden
(författare)
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Kupczyk, MInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden; Dept of Internal Medicine, Asthma and Allergy, Medical University of Lodz, University of Lodz, Lodz, Poland
(författare)
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De Meulder, BEuropean Institute for Systems Biology and Medicine, Lyon, France,Dept of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Modena, Italy
(författare)
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Auffray, CEuropean Institute for Systems Biology and Medicine, Lyon, France
(författare)
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Bakke, PSDept of Clinical Science, University of Bergen, Bergen, Norway
(författare)
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Beghe, B
(författare)
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Bel, EHDept of Respiratory Medicine, University of Amsterdam, Amsterdam, Netherlands
(författare)
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Caruso, MDept of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy
(författare)
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Chanez, PAssistance Publique des Hôpitaux de Marseille, Clinique des Bronches, Allergies et Sommeil, Aix Marseille Université, Marseille, France
(författare)
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Chawes, BCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark
(författare)
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Fowler, SJDivision of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, The University of Manchester; Manchester Academic Health Science Centre and NIHR Manchester Biomedical Research Centre, Manchester University Hospitals NHS Foundation Trust, Manchester, UK
(författare)
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Gaga, MRespiratory Medicine Dept and Asthma Centre, Athens Chest Hospital "Sotiria", University of Athens, Athens, Greece
(författare)
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Geiser, TDept for Pulmonary Medicine, University Hospital and University of Bern, Bern, Switzerland
(författare)
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Gjomarkaj, MInstitute for Research and Biomedical Innovation, Italian National Research Council, Palermo, Italy
(författare)
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Horvath, IDept of Pulmonology, Semmelweis University, Budapest, Hungary
(författare)
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Howarth, PHNIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom
(författare)
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Johnston, SLNational Heart and Lung Institute, Imperial College London, London, United Kingdom
(författare)
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Joos, GDept of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium; Dept of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium
(författare)
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Krug, NFraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany
(författare)
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Montuschi, PDept of Pharmacology, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy
(författare)
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Musial, JKarolinska Institutet
(författare)
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Nizankowska-Mogilnicka, EDept of Internal Medicine, Jagiellonian University Medical College, Krakow, Poland
(författare)
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Olsson, HKTranslational Science and Experimental Medicine, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden
(författare)
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Papi, ADivision of lnternal and Cardiorespiratory Medicine, University of Ferrara, Ferrara, Italy
(författare)
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Rabe, KFDept of Internal Medicine, Christian Albrechts University Kiel, Kiel, Germany
(författare)
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Sandström, Thomas,1957-Umeå universitet,Avdelningen för medicin(Swepub:umu)thsa0001
(författare)
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Shaw, DEKarolinska Institutet
(författare)
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Siafakas, NM
(författare)
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Uhlén, MathiasKTH,Science for Life Laboratory, SciLifeLab,Systembiologi,Karolinska Inst, Dept Neurosci, Stockholm, Sweden.(Swepub:kth)u1dulvmw
(författare)
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Riley, JHRespiratory Therapeutic Unit, GlaxoSmithKline, London, United Kingdom
(författare)
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Bates, SRespiratory Therapeutic Unit, GlaxoSmithKline, London, United Kingdom
(författare)
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Middelveld, RJMKarolinska Institutet
(författare)
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Wheelock, CEKarolinska Institutet,Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden; Dept of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden; Dept of Respiratory Medicine and Allergy, Karolinska University Hospital, Stockholm, Sweden
(författare)
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Chung, KFNational Heart and Lung Institute, Imperial College London, London, United Kingdom
(författare)
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Adcock, IMNational Heart and Lung Institute, Imperial College London, London, United Kingdom
(författare)
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Sterk, PJDept of Respiratory Medicine, University of Amsterdam, Amsterdam, Netherlands
(författare)
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Djukanovic, RNIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom
(författare)
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Nilsson, PeterKTH,Science for Life Laboratory, SciLifeLab,Affinitets-proteomik(Swepub:kth)u1ws88sk
(författare)
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Dahlen, SEKarolinska Institutet,Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden; Dept of Respiratory Medicine and Allergy, Karolinska University Hospital, Stockholm, Sweden
(författare)
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James, AInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Inst Environm Med, Stockholm, Sweden.;Karolinska Inst, Ctr Allergy Res, Stockholm, Sweden.
(författare)
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Karolinska InstitutetDept of Protein Science, KTH Royal Institute of Technology, SciLifeLab, Stockholm, Sweden; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:The European respiratory journal: European Respiratory Society (ERS)59:21399-30030903-1936
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Till lärosätets databas
- Av författaren/redakt...
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Mikus, MS
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Kolmert, J
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Andersson, LI
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Ostling, J
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Knowles, RG
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Gomez, C
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visa fler...
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Ericsson, M
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Thorngren, JO
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Khoonsari, PE
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Dahlen, B
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Kupczyk, M
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De Meulder, B
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Auffray, C
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Bakke, PS
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Beghe, B
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Bel, EH
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Caruso, M
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Chanez, P
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Chawes, B
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Fowler, SJ
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Gaga, M
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Geiser, T
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Gjomarkaj, M
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Horvath, I
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Howarth, PH
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Johnston, SL
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Joos, G
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Krug, N
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Montuschi, P
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Musial, J
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Nizankowska-Mogi ...
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Olsson, HK
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Papi, A
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Rabe, KF
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Sandström, Thoma ...
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Shaw, DE
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Siafakas, NM
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Uhlén, Mathias
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Riley, JH
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Bates, S
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Middelveld, RJM
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Wheelock, CE
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Chung, KF
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Adcock, IM
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Sterk, PJ
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Djukanovic, R
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Nilsson, Peter
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Dahlen, SE
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James, A
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