Search: WFRF:(Wheelock M)
> (2020-2024) >
Plasma proteins ele...
Plasma proteins elevated in severe asthma despite oral steroid use and unrelated to Type-2 inflammation
-
- Mikus, MS (author)
- Karolinska Institutet,Dept of Protein Science, KTH Royal Institute of Technology, SciLifeLab, Stockholm, Sweden; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden,Dept of Thoracic Medicine, Medical School, University of Crete, Heraklion, Crete, Greece
-
- Kolmert, J (author)
- Karolinska Institutet,Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden
-
- Andersson, LI (author)
- Karolinska Institutet,Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden
-
show more...
-
- Ostling, J (author)
- Gothenburg, Sweden
-
- Knowles, RG (author)
- Knowles Consulting, Stevenage Bioscience Catalyst, Stevenage, United Kingdom
-
- Gomez, C (author)
- Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden
-
- Ericsson, M (author)
- Dept of Laboratory Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden
-
- Thorngren, JO (author)
- Dept of Laboratory Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden
-
- Khoonsari, PE (author)
- Dept of Biochemistry and Biophysics, National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Solna, Sweden
-
- Dahlen, B (author)
- Karolinska Institutet,Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden; Dept of Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden
-
- Kupczyk, M (author)
- Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden; Dept of Internal Medicine, Asthma and Allergy, Medical University of Lodz, University of Lodz, Lodz, Poland
-
- De Meulder, B (author)
- European Institute for Systems Biology and Medicine, Lyon, France,Dept of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Modena, Italy
-
- Auffray, C (author)
- European Institute for Systems Biology and Medicine, Lyon, France
-
- Bakke, PS (author)
- Dept of Clinical Science, University of Bergen, Bergen, Norway
-
Beghe, B (author)
-
- Bel, EH (author)
- Dept of Respiratory Medicine, University of Amsterdam, Amsterdam, Netherlands
-
- Caruso, M (author)
- Dept of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy
-
- Chanez, P (author)
- Assistance Publique des Hôpitaux de Marseille, Clinique des Bronches, Allergies et Sommeil, Aix Marseille Université, Marseille, France
-
- Chawes, B (author)
- COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark
-
- Fowler, SJ (author)
- Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, The University of Manchester; Manchester Academic Health Science Centre and NIHR Manchester Biomedical Research Centre, Manchester University Hospitals NHS Foundation Trust, Manchester, UK
-
- Gaga, M (author)
- Respiratory Medicine Dept and Asthma Centre, Athens Chest Hospital "Sotiria", University of Athens, Athens, Greece
-
- Geiser, T (author)
- Dept for Pulmonary Medicine, University Hospital and University of Bern, Bern, Switzerland
-
- Gjomarkaj, M (author)
- Institute for Research and Biomedical Innovation, Italian National Research Council, Palermo, Italy
-
- Horvath, I (author)
- Dept of Pulmonology, Semmelweis University, Budapest, Hungary
-
- Howarth, PH (author)
- NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom
-
- Johnston, SL (author)
- National Heart and Lung Institute, Imperial College London, London, United Kingdom
-
- Joos, G (author)
- Dept of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium; Dept of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium
-
- Krug, N (author)
- Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany
-
- Montuschi, P (author)
- Dept of Pharmacology, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy
-
- Musial, J (author)
- Karolinska Institutet
-
- Nizankowska-Mogilnicka, E (author)
- Dept of Internal Medicine, Jagiellonian University Medical College, Krakow, Poland
-
- Olsson, HK (author)
- Translational Science and Experimental Medicine, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden
-
- Papi, A (author)
- Division of lnternal and Cardiorespiratory Medicine, University of Ferrara, Ferrara, Italy
-
- Rabe, KF (author)
- Dept of Internal Medicine, Christian Albrechts University Kiel, Kiel, Germany
-
- Sandström, Thomas, 1957- (author)
- Umeå universitet,Avdelningen för medicin
-
- Shaw, DE (author)
- Karolinska Institutet
-
Siafakas, NM (author)
-
- Uhlén, Mathias (author)
- KTH,Science for Life Laboratory, SciLifeLab,Systembiologi,Karolinska Inst, Dept Neurosci, Stockholm, Sweden.
-
- Riley, JH (author)
- Respiratory Therapeutic Unit, GlaxoSmithKline, London, United Kingdom
-
- Bates, S (author)
- Respiratory Therapeutic Unit, GlaxoSmithKline, London, United Kingdom
-
- Middelveld, RJM (author)
- Karolinska Institutet
-
- Wheelock, CE (author)
- Karolinska Institutet,Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden; Dept of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden; Dept of Respiratory Medicine and Allergy, Karolinska University Hospital, Stockholm, Sweden
-
- Chung, KF (author)
- National Heart and Lung Institute, Imperial College London, London, United Kingdom
-
- Adcock, IM (author)
- National Heart and Lung Institute, Imperial College London, London, United Kingdom
-
- Sterk, PJ (author)
- Dept of Respiratory Medicine, University of Amsterdam, Amsterdam, Netherlands
-
- Djukanovic, R (author)
- NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom
-
- Nilsson, Peter (author)
- KTH,Science for Life Laboratory, SciLifeLab,Affinitets-proteomik
-
- Dahlen, SE (author)
- Karolinska Institutet,Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden; Dept of Respiratory Medicine and Allergy, Karolinska University Hospital, Stockholm, Sweden
-
- James, A (author)
- Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Inst Environm Med, Stockholm, Sweden.;Karolinska Inst, Ctr Allergy Res, Stockholm, Sweden.
-
show less...
-
(creator_code:org_t)
- 2021-11-04
- 2022
- English.
-
In: The European respiratory journal. - : European Respiratory Society (ERS). - 1399-3003 .- 0903-1936. ; 59:2
- Related links:
-
https://erj.ersjourn...
-
show more...
-
https://doi.org/10.1...
-
https://umu.diva-por... (primary) (Raw object)
-
http://kipublication...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
https://urn.kb.se/re...
-
show less...
Abstract
Subject headings
Close
- Asthma phenotyping requires novel biomarker discovery.ObjectivesTo identify plasma biomarkers associated with asthma phenotypes by application of a new proteomic panel to samples from two well-characterised cohorts of severe (SA) and mild-to-moderate (MMA) asthmatics, COPD subjects and healthy controls (HCs).MethodsAn antibody-based array targeting 177 proteins predominantly involved in pathways relevant to inflammation, lipid metabolism, signal transduction and extracellular matrix was applied to plasma from 525 asthmatics and HCs in the U-BIOPRED cohort, and 142 subjects with asthma and COPD from the validation cohort BIOAIR. Effects of oral corticosteroids (OCS) were determined by a 2-week, placebo-controlled OCS trial in BIOAIR, and confirmed by relation to objective OCS measures in U-BIOPRED.ResultsIn U-BIOPRED, 110 proteins were significantly different, mostly elevated, in SA compared to MMA and HCs. 10 proteins were elevated in SA versus MMA in both U-BIOPRED and BIOAIR (alpha-1-antichymotrypsin, apolipoprotein-E, complement component 9, complement factor I, macrophage inflammatory protein-3, interleukin-6, sphingomyelin phosphodiesterase 3, TNF receptor superfamily member 11a, transforming growth factor-β and glutathione S-transferase). OCS treatment decreased most proteins, yet differences between SA and MMA remained following correction for OCS use. Consensus clustering of U-BIOPRED protein data yielded six clusters associated with asthma control, quality of life, blood neutrophils, high-sensitivity C-reactive protein and body mass index, but not Type-2 inflammatory biomarkers. The mast cell specific enzyme carboxypeptidase A3 was one major contributor to cluster differentiation.ConclusionsThe plasma proteomic panel revealed previously unexplored yet potentially useful Type-2-independent biomarkers and validated several proteins with established involvement in the pathophysiology of SA.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Mikus, MS
-
Kolmert, J
-
Andersson, LI
-
Ostling, J
-
Knowles, RG
-
Gomez, C
-
show more...
-
Ericsson, M
-
Thorngren, JO
-
Khoonsari, PE
-
Dahlen, B
-
Kupczyk, M
-
De Meulder, B
-
Auffray, C
-
Bakke, PS
-
Beghe, B
-
Bel, EH
-
Caruso, M
-
Chanez, P
-
Chawes, B
-
Fowler, SJ
-
Gaga, M
-
Geiser, T
-
Gjomarkaj, M
-
Horvath, I
-
Howarth, PH
-
Johnston, SL
-
Joos, G
-
Krug, N
-
Montuschi, P
-
Musial, J
-
Nizankowska-Mogi ...
-
Olsson, HK
-
Papi, A
-
Rabe, KF
-
Sandström, Thoma ...
-
Shaw, DE
-
Siafakas, NM
-
Uhlén, Mathias
-
Riley, JH
-
Bates, S
-
Middelveld, RJM
-
Wheelock, CE
-
Chung, KF
-
Adcock, IM
-
Sterk, PJ
-
Djukanovic, R
-
Nilsson, Peter
-
Dahlen, SE
-
James, A
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Respiratory Medi ...
- Articles in the publication
-
The European res ...
- By the university
-
Karolinska Institutet
-
Umeå University
-
Royal Institute of Technology