Search: id:"swepub:oai:prod.swepub.kib.ki.se:149687294" >
Autophagy regulatio...
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Gonzalez-Rodriguez, P
(author)
Autophagy regulation by RNA alternative splicing and implications in human diseases
- Article/chapterEnglish2022
Publisher, publication year, extent ...
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2022-05-18
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Springer Science and Business Media LLC,2022
Numbers
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:149687294
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http://kipublications.ki.se/Default.aspx?queryparsed=id:149687294URI
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https://doi.org/10.1038/s41467-022-30433-1DOI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Autophagy and RNA alternative splicing are two evolutionarily conserved processes involved in overlapping physiological and pathological processes. However, the extent of functional connection is not well defined. Here, we consider the role for alternative splicing and generation of autophagy-related gene isoforms in the regulation of autophagy in recent work. The impact of changes to the RNA alternative splicing machinery and production of alternative spliced isoforms on autophagy are reviewed with particular focus on disease relevance. The use of drugs targeting both alternative splicing and autophagy as well as the selective regulation of single autophagy-related protein isoforms, are considered as therapeutic strategies.
Added entries (persons, corporate bodies, meetings, titles ...)
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Klionsky, DJ
(author)
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Joseph, BKarolinska Institutet
(author)
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Karolinska Institutet
(creator_code:org_t)
Related titles
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In:Nature communications: Springer Science and Business Media LLC13:1, s. 2735-2041-1723
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