Search: WFRF:(Janoueix Lerosey I.) >
BET and CDK Inhibit...
BET and CDK Inhibition Reveal Differences in the Proliferation Control of Sympathetic Ganglion Neuroblasts and Adrenal Chromaffin Cells
- Article/chapterEnglish2022
Publisher, publication year, extent ...
Numbers
-
LIBRIS-ID:oai:prod.swepub.kib.ki.se:149841233
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:149841233URI
-
https://doi.org/10.3390/cancers14112755DOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
Neuroblastoma arising from the adrenal differ from ganglionic neuroblastoma both genetically and clinically, with adrenal tumors being associated with a more severe prognosis. The different tumor properties may be linked to specific tumor founder cells in adrenal and sympathetic ganglia. To address this question, we first set up cultures of mouse sympathetic neuroblasts and adrenal chromaffin cells. These cultures were then treated with various proliferation inhibitors to identify lineage-specific responses. We show that neuroblast and chromaffin cell proliferation was affected by WNT, ALK, IGF1, and PRC2/EZH2 signaling inhibitors to a similar extent. However, differential effects were observed in response to bromodomain and extraterminal (BET) protein inhibitors (JQ1, GSK1324726A) and to the CDK-7 inhibitor THZ1, with BET inhibitors preferentially affecting chromaffin cells, and THZ1 preferentially affecting neuroblasts. The differential dependence of chromaffin cells and neuroblasts on BET and CDK signaling may indicate different mechanisms during tumor initiation in sympathetic ganglia and adrenal.
Added entries (persons, corporate bodies, meetings, titles ...)
-
Louis-Brennetot, C
(author)
-
Pierre-Eugene, C
(author)
-
Baulande, S
(author)
-
Raynal, V
(author)
-
Kramdi, A
(author)
-
Adameyko, IKarolinska Institutet
(author)
-
Ernsberger, U
(author)
-
Deller, T
(author)
-
Delattre, O
(author)
-
Janoueix-Lerosey, I
(author)
-
Rohrer, H
(author)
-
Karolinska Institutet
(creator_code:org_t)
Related titles
-
In:Cancers: MDPI AG14:112072-6694
Internet link
Find in a library
-
Cancers
(Search for host publication in LIBRIS)
To the university's database
- By the author/editor
-
Sriha, J
-
Louis-Brennetot, ...
-
Pierre-Eugene, C
-
Baulande, S
-
Raynal, V
-
Kramdi, A
-
show more...
-
Adameyko, I
-
Ernsberger, U
-
Deller, T
-
Delattre, O
-
Janoueix-Lerosey ...
-
Rohrer, H
-
show less...
- Articles in the publication
-
Cancers
- By the university
-
Karolinska Institutet