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Echocardiographic P...
Echocardiographic Prognosis Relevance of Attenuated Right Heart Remodeling in Idiopathic Pulmonary Arterial Hypertension
- Article/chapterEnglish2021
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2021-05-07
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Frontiers Media SA,2021
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:149869992
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http://kipublications.ki.se/Default.aspx?queryparsed=id:149869992URI
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https://doi.org/10.3389/fcvm.2021.650848DOI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Background: Right ventricular (RV) function is a great determination of the fate in patients with pulmonary arterial hypertension (PAH). Monitoring RV structure back to normal or improvement should be useful for evaluation of RV function. The aims of this study were to assess the prognostic relevance of changed right heart (RH) dimensions by echocardiography and attenuated RH remodeling (ARHR) in idiopathic PAH (IPAH).Methods: We retrospectively analyzed 232 consecutive adult IPAH patients at baseline assessment and included RH catheterization and echocardiography. ARHR at the mean 20 ± 12 months' follow-up was defined by a decreased right atrium area, RV mid-diameter, and left ventricular end-diastolic eccentricity index. The follow-up end point was all-cause mortality.Results: At mean 20 ± 12 months' follow-up, 33 of 232 patients (14.2%) presented with ARHR. The remaining 199 surviving patients were monitored for another 25 ± 20 months. At the end of follow-up, the survival rates at 1, 3, and 5 years were 89, 89, and 68% in patients with ARHR, respectively, and 84, 65 and 41% in patients without ARHR (log-rank p = 0.01). ARHR was an independent prognostic factor for mortality. Besides, ARHR was available to further stratify patients' risk assessment through the French PAH non-invasive-risk criteria.Conclusions: Echocardiographic ARHR is an independent determinant of prognosis in IPAH at long-term follow-up. ARHR might be a useful tool to indicate the RV morphologic and functional improvement associated with better prognostic likelihood.
Added entries (persons, corporate bodies, meetings, titles ...)
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Gong, SG
(author)
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Jiang, R
(author)
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Li, C
(author)
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Chen, GFKarolinska Institutet
(author)
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Luo, CJ
(author)
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Qiu, HL
(author)
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Liu, JM
(author)
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Wang, L
(author)
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Zhang, R
(author)
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Karolinska Institutet
(creator_code:org_t)
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In:Frontiers in cardiovascular medicine: Frontiers Media SA8, s. 650848-2297-055X
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Zhao, QH
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Gong, SG
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Jiang, R
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Li, C
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Chen, GF
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Luo, CJ
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Qiu, HL
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Liu, JM
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Wang, L
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Zhang, R
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Karolinska Institutet