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Long COVID burden and risk factors in 10 UK longitudinal studies and electronic health records

Thompson, EJ (author)
Williams, DM (author)
Walker, AJ (author)
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Mitchell, RE (author)
Niedzwiedz, CL (author)
Yang, TC (author)
Huggins, CF (author)
Kwong, ASF (author)
Silverwood, RJ (author)
Di Gessa, G (author)
Bowyer, RCE (author)
Northstone, K (author)
Hou, B (author)
Green, MJ (author)
Dodgeon, B (author)
Doores, KJ (author)
Duncan, EL (author)
Williams, FMK (author)
Steptoe, A (author)
Porteous, DJ (author)
McEachan, RRC (author)
Tomlinson, L (author)
Goldacre, B (author)
Patalay, P (author)
Ploubidis, GB (author)
Katikireddi, SV (author)
Tilling, K (author)
Rentsch, CT (author)
Timpson, NJ (author)
Chaturvedi, N (author)
Steves, CJ (author)
Walker, AJ (author)
MacKenna, B (author)
Inglesby, P (author)
Curtis, HJ (author)
Morton, CE (author)
Morley, J (author)
Mehrkar, A (author)
Bacon, S (author)
Hickman, G (author)
Bates, C (author)
Croker, R (author)
Evans, D (author)
Ward, T (author)
Cockburn, J (author)
Davy, S (author)
Bhaskaran, K (author)
Schultze, A (author)
Williamson, EJ (author)
Hulme, WJ (author)
Davy, S (author)
McDonald, HI (author)
Mathur, R (author)
Eggo, RM (author)
Wing, K (author)
Wong, AYS (author)
Forbes, H (author)
Tazare, J (author)
Parry, J (author)
Hester, F (author)
Harper, S (author)
Douglas, IJ (author)
Evans, SJW (author)
Smeeth, L (author)
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2022-06-28
2022
English.
In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 13:1, s. 3528-
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • The frequency of, and risk factors for, long COVID are unclear among community-based individuals with a history of COVID-19. To elucidate the burden and possible causes of long COVID in the community, we coordinated analyses of survey data from 6907 individuals with self-reported COVID-19 from 10 UK longitudinal study (LS) samples and 1.1 million individuals with COVID-19 diagnostic codes in electronic healthcare records (EHR) collected by spring 2021. Proportions of presumed COVID-19 cases in LS reporting any symptoms for 12+ weeks ranged from 7.8% and 17% (with 1.2 to 4.8% reporting debilitating symptoms). Increasing age, female sex, white ethnicity, poor pre-pandemic general and mental health, overweight/obesity, and asthma were associated with prolonged symptoms in both LS and EHR data, but findings for other factors, such as cardio-metabolic parameters, were inconclusive.

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