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Factors associated ...
Factors associated with severe COVID-19 in people with idiopathic inflammatory myopathy: results from the COVID-19 Global Rheumatology Alliance physician-reported registry
- Article/chapterEnglish2022
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:150673946
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http://kipublications.ki.se/Default.aspx?queryparsed=id:150673946URI
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https://doi.org/10.1136/rmdopen-2022-002508DOI
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Language:English
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Summary in:English
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To investigate factors associated with severe COVID-19 in people with idiopathic inflammatory myopathy (IIM).MethodsDemographic data, clinical characteristics and COVID-19 outcome severity of adults with IIM were obtained from the COVID-19 Global Rheumatology Alliance physician-reported registry. A 3-point ordinal COVID-19 severity scale was defined: (1) no hospitalisation, (2) hospitalisation (and no death) and (3) death. ORs were estimated using multivariable ordinal logistic regression. Sensitivity analyses were performed using a 4-point ordinal scale: (1) no hospitalisation, (2) hospitalisation with no oxygen (and no death), (3) hospitalisation with oxygen/ventilation (and no death) and 4) death.ResultsOf 348 patients, 48% were not hospitalised, 39% were hospitalised (and did not die) and 13% died. Older age (OR=1.59/decade, 95% CI 1.31 to 1.91), high disease activity (OR=3.50, 95% CI 1.25 to 9.83; vs remission), ≥2 comorbidities (OR=2.63, 95% CI 1.39 to 4.98; vs none), prednisolone-equivalent dose >7.5 mg/day (OR=2.40, 95% CI 1.09 to 5.28; vs no intake) and exposure to rituximab (OR=2.71, 95% CI 1.28 to 5.72; vs conventional synthetic disease-modifying antirheumatic drugs only) were independently associated with severe COVID-19. In addition to these variables, in the sensitivity analyses, male sex (OR range: 1.65–1.83; vs female) was also significantly associated with severe outcomes, while COVID-19 diagnosis after 1 October 2020 (OR range: 0.51–0.59; vs on/before 15 June 2020) was significantly associated with less severe outcomes, but these associations were not significant in the main model (OR=1.57, 95% CI 0.95 to 2.59; and OR=0.61, 95% CI 0.37 to 1.00; respectively).ConclusionsThis is the first large registry data on outcomes of COVID-19 in people with IIM. Older age, male sex, higher comorbidity burden, high disease activity, prednisolone-equivalent dose >7.5 mg/day and rituximab exposure were associated with severe COVID-19. These findings will enable risk stratification and inform management decisions for patients with IIM.
Added entries (persons, corporate bodies, meetings, titles ...)
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Gianfrancesco, M
(author)
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Lawson-Tovey, S
(author)
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Hyrich, KL
(author)
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Strangfeld, A
(author)
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Gossec, L
(author)
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Carmona, L
(author)
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Mateus, EF
(author)
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Schafer, M
(author)
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Richez, C
(author)
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Hachulla, E
(author)
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Holmqvist, MKarolinska Institutet
(author)
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Scire, CA
(author)
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Lorenz, HM
(author)
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Voll, RE
(author)
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Hasseli, R
(author)
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Jayatilleke, A
(author)
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Hsu, TYT
(author)
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D'Silva, KM
(author)
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Pimentel-Quiroz, VR
(author)
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del Mercado, MV
(author)
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Shinjo, SK
(author)
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Neto, ETD
(author)
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da Rocha, LF
(author)
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Montandon, ACDES
(author)
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Pons-Estel, GJ
(author)
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Ornella, S
(author)
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Exeni, MED
(author)
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Velozo, E
(author)
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Jordan, P
(author)
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Sirotich, E
(author)
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Hausmann, JS
(author)
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Liew, JW
(author)
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Jacobsohn, L
(author)
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Gore-Massy, M
(author)
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Sufka, P
(author)
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Grainger, R
(author)
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Bhana, S
(author)
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Wallace, Z
(author)
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Robinson, PC
(author)
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Yazdany, J
(author)
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Machado, PM
(author)
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Karolinska Institutet
(creator_code:org_t)
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Jordan, P
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