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Allergen provocatio...
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Gauvreau, GMMcMaster University
(författare)
Allergen provocation tests in respiratory research: building on 50 years of experience
- Artikel/kapitelEngelska2022
Förlag, utgivningsår, omfång ...
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2022-01-27
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European Respiratory Society (ERS),2022
Nummerbeteckningar
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:150788552
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http://kipublications.ki.se/Default.aspx?queryparsed=id:150788552URI
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https://doi.org/10.1183/13993003.02782-2021DOI
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https://lup.lub.lu.se/record/14eb09f3-319f-4611-8f36-a1454186900aURI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
Ingår i deldatabas
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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The allergen provocation test is an established model of allergic airway diseases, including asthma and allergic rhinitis, allowing the study of allergen-induced changes in respiratory physiology and inflammatory mechanisms in sensitised individuals as well as their associations. In the upper airways, allergen challenge is focused on the clinical and pathophysiological sequelae of the early allergic response, and is applied both as a diagnostic tool and in research settings. In contrast, bronchial allergen challenge has almost exclusively served as a research tool in specialised research settings with a focus on the late asthmatic response and the underlying type 2 inflammation. The allergen-induced late asthmatic response is also characterised by prolonged airway narrowing, increased nonspecific airway hyperresponsiveness and features of airway remodelling including the small airways, and hence allows the study of several key mechanisms and features of asthma. In line with these characteristics, allergen challenge has served as a valued tool to study the cross-talk of the upper and lower airways and in proof-of-mechanism studies of drug development. In recent years, several new insights into respiratory phenotypes and endotypes including the involvement of the upper and small airways, innovative biomarker sampling methods and detection techniques, refined lung function testing as well as targeted treatment options further shaped the applicability of the allergen provocation test in precision medicine. These topics, along with descriptions of subject populations and safety, in line with the updated Global Initiative for Asthma 2021 document, will be addressed in this review.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Davis, BEUniversity of Saskatchewan
(författare)
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Scadding, GImperial College London
(författare)
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Boulet, LPLaval University
(författare)
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Bjermer, LeifLund University,Lunds universitet,Lungmedicin, allergologi och palliativ medicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Klinisk lungmedicin,Forskargrupper vid Lunds universitet,Respiratory Medicine, Allergology, and Palliative Medicine,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Clinical Respiratory Medicine,Lund University Research Groups(Swepub:lu)lung-lbj
(författare)
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Chaker, ATechnical University of Munich,Klinikum rechts der Isar
(författare)
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Cockcroft, DWUniversity of Saskatchewan
(författare)
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Dahlen, BKarolinska Institute,Karolinska Institutet
(författare)
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Fokkens, WTechnical University of Munich,Klinikum rechts der Isar
(författare)
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Hellings, PUniversity of Amsterdam
(författare)
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Lazarinis, NKarolinska Institute,Karolinska Institutet
(författare)
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O'Byrne, PMMcMaster University
(författare)
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Tufvesson, EllenLund University,Lunds universitet,Lungmedicin, allergologi och palliativ medicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neonatologi,Forskargrupper vid Lunds universitet,Tornbladinstitutet,Lungfysiologi och biomarkörer,Respiratory Medicine, Allergology, and Palliative Medicine,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Neonatology,Lund University Research Groups,Tornblad Institute,Lung physiology and biomarkers(Swepub:lu)medk-etu
(författare)
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Quirce, SUniversity Hospital La Paz
(författare)
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Van Maaren, MErasmus University Medical Center
(författare)
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de Jongh, FHUniversity of Twente
(författare)
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Diamant, ZuzanaLund University,Lunds universitet,Lungmedicin, allergologi och palliativ medicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Respiratory Medicine, Allergology, and Palliative Medicine,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Catholic University of Leuven,University Medical Center Groningen,Skåne University Hospital(Swepub:lu)med-zdt
(författare)
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McMaster UniversityUniversity of Saskatchewan
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:The European respiratory journal: European Respiratory Society (ERS)60:21399-30030903-1936
Internetlänk
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Gauvreau, GM
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Davis, BE
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Scadding, G
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Boulet, LP
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Bjermer, Leif
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Chaker, A
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visa fler...
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Cockcroft, DW
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Dahlen, B
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Fokkens, W
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Hellings, P
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Lazarinis, N
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O'Byrne, PM
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Tufvesson, Ellen
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Quirce, S
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Van Maaren, M
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de Jongh, FH
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Diamant, Zuzana
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Lungmedicin och ...
- Artiklar i publikationen
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The European res ...
- Av lärosätet
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Karolinska Institutet
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Lunds universitet