SwePub
Sök i LIBRIS databas

  Extended search

WFRF:(de Gans K)
 

Search: WFRF:(de Gans K) > (2020-2024) > Heterogeneity on lo...

  • Signori, A (author)

Heterogeneity on long-term disability trajectories in patients with secondary progressive MS: a latent class analysis from Big MS Data network

  • Article/chapterEnglish2023

Publisher, publication year, extent ...

  • 2022-09-28
  • BMJ,2023

Numbers

  • LIBRIS-ID:oai:prod.swepub.kib.ki.se:150794163
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:150794163URI
  • https://doi.org/10.1136/jnnp-2022-329987DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Over the decades, several natural history studies on patients with primary (PPMS) or secondary progressive multiple sclerosis (SPMS) were reported from international registries. In PPMS, a consistent heterogeneity on long-term disability trajectories was demonstrated. The aim of this study was to identify subgroups of patients with SPMS with similar longitudinal trajectories of disability over time.MethodsAll patients with MS collected within Big MS registries who received an SPMS diagnosis from physicians (cohort 1) or satisfied the Lorscheider criteria (cohort 2) were considered. Longitudinal Expanded Disability Status Scale (EDSS) scores were modelled by a latent class growth analysis (LCGA), using a non-linear function of time from the first EDSS visit in the range 3–4.ResultsA total of 3613 patients with SPMS were included in the cohort 1. LCGA detected three different subgroups of patients with a mild (n=1297; 35.9%), a moderate (n=1936; 53.6%) and a severe (n=380; 10.5%) disability trajectory. Median time to EDSS 6 was 12.1, 5.0 and 1.7 years, for the three groups, respectively; the probability to reach EDSS 6 at 8 years was 14.4%, 78.4% and 98.3%, respectively. Similar results were found among 7613 patients satisfying the Lorscheider criteria.ConclusionsContrary to previous interpretations, patients with SPMS progress at greatly different rates. Our identification of distinct trajectories can guide better patient selection in future phase 3 SPMS clinical trials. Additionally, distinct trajectories could reflect heterogeneous pathological mechanisms of progression.

Added entries (persons, corporate bodies, meetings, titles ...)

  • Lorscheider, J (author)
  • Vukusic, S (author)
  • Trojano, M (author)
  • Iaffaldano, P (author)
  • Hillert, JKarolinska Institutet (author)
  • Hyde, R (author)
  • Pellegrini, F (author)
  • Magyari, M (author)
  • Koch-Henriksen, N (author)
  • Sorensen, PS (author)
  • Spelman, T (author)
  • van Der Walt, A (author)
  • Horakova, D (author)
  • Havrdova, E (author)
  • Girard, M (author)
  • Eichau, S (author)
  • Grand'Maison, F (author)
  • Gerlach, O (author)
  • Terzi, M (author)
  • Ozakbas, S (author)
  • Skibina, O (author)
  • Van Pesch, V (author)
  • Sa, MJ (author)
  • Prevost, J (author)
  • Alroughani, R (author)
  • McCombe, PA (author)
  • Gouider, R (author)
  • Mrabet, S (author)
  • Castillo-Trivino, T (author)
  • Zhu, C (author)
  • de Gans, K (author)
  • Sanchez-Menoyo, JL (author)
  • Yamout, B (author)
  • Khoury, S (author)
  • Sormani, MP (author)
  • Kalincik, T (author)
  • Butzkueven, H (author)
  • Karolinska Institutet (creator_code:org_t)

Related titles

  • In:Journal of neurology, neurosurgery, and psychiatry: BMJ94:1, s. 23-301468-330X0022-3050

Internet link

Find in a library

To the university's database

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view