Search: WFRF:(Holmer M.) >
Associations betwee...
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Holmer, MKarolinska Institutet
(author)
Associations between subcutaneous adipocyte hypertrophy and nonalcoholic fatty liver disease
- Article/chapterEnglish2022
Publisher, publication year, extent ...
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2022-11-28
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Springer Science and Business Media LLC,2022
Numbers
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:151278844
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http://kipublications.ki.se/Default.aspx?queryparsed=id:151278844URI
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https://doi.org/10.1038/s41598-022-24482-1DOI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Adipocyte hypertrophy and expression of adipokines in subcutaneous adipose tissue (SAT) have been linked to steatosis, nonalcoholic steatohepatitis (NASH) and fibrosis in morbidly obese (BMI ≥ 40 kg/m2) subjects. It is unknown if this is also true for subjects with NAFLD with lesser degrees of obesity (BMI < 35 kg/m2). Thirty-two subjects with biopsy-proven NAFLD and 15 non-diabetic controls matched for BMI underwent fine-needle biopsies of SAT. Adipocyte volume was calculated. RNA-sequencing of SAT was performed in a subset of 20 NAFLD patients. Adipocyte volume and gene expression levels were correlated to the presence of NASH or significant fibrosis. Subjects with NAFLD had larger adipocyte volume compared with controls, (1939 pL, 95% CI 1130–1662 vs. 854 pL, 95% CI 781–926, p < 0.001). There was no association between adipocyte volume and the presence of NASH. Gene expression of adipokines previously described to correlate with NASH in morbid obesity, was not associated with NASH or fibrosis. Our results suggest that persons with NAFLD have larger SAT adipocytes compared with controls and that adipocytes are involved in the pathophysiology of hepatic steatosis in NAFLD. However, adipocyte volume was not associated with NASH or fibrosis in NAFLD subjects with varying degrees of obesity.
Added entries (persons, corporate bodies, meetings, titles ...)
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Hagstrom, HKarolinska Institutet
(author)
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Chen, PKarolinska Institutet
(author)
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Danielsson, O
(author)
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Aouadi, M
(author)
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Ryden, MKarolinska Institutet
(author)
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Stal, PKarolinska Institutet
(author)
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Karolinska Institutet
(creator_code:org_t)
Related titles
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In:Scientific reports: Springer Science and Business Media LLC12:1, s. 20519-2045-2322
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