SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Gatto F)
 

Sökning: WFRF:(Gatto F) > Breast cyst fluid h...

  • Mannello, F.Universita degli Studi di Urbino Carlo Bo,University of Urbino (författare)

Breast cyst fluid heparan sulphate is distinctively N-sulphated depending on apocrine or flattened type

  • Artikel/kapitelEngelska2015

Förlag, utgivningsår, omfång ...

  • 2015-03-06
  • Wiley,2015

Nummerbeteckningar

  • LIBRIS-ID:oai:research.chalmers.se:a1ccac90-7933-4b97-bc53-f0c11655b1ad
  • https://doi.org/10.1002/cbf.3096DOI
  • https://research.chalmers.se/publication/217910URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • Breast cyst fluid (BCF) contained in gross cists is involved with its many biomolecules in different stages of breast cystic development. Type I apocrine and type II flattened cysts are classified based on biochemical, morphological and hormonal differences, and their different patterns of growth factors and active biocompounds may require different regulation. In a previous paper, hyaluronic acid in a very low content and chondroitin sulphate/dermatan sulphate were identified and characterized in BCF. In this new study, various apocrine and flattened BCFs were analyzed for HS concentration and disaccharide pattern. Apocrine HS was found specifically constituted of N-acetyl groups contrary to flattened HS richer in N-sulphate disaccharides with an overall N-acetylated/N-sulphated ratio significantly increased in apocrine compared with flattened (13.5 vs 3.7). Related to this different structural features, the charge density significantly decreased (-30%) in apocrine versus flattened BCFs. Finally, no significant differences were observed for HS amount (0.9-1.3 mu gml(-1)) between the two BCF types even if a greater content was determined for flattened samples. The specifically N-sulphated sequences in flattened BCF HS can exert biologic capacity by regulating growth factors activity. On the other hand, we cannot exclude a peculiar regulation of the activity of biomolecules in apocrine BCF by HS richer in N-acetylated disaccharides. In fact, the different patterns of growth factors and active biocompounds in the two types of cysts may require different regulation by specific sequences in the HS backbone possessing specific structural characteristics and distinctive chemical groups.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Maccari, F.Universita Degli Studi Di Modena E Reggio Emilia,University of Modena and Reggio Emilia (författare)
  • Ligi, D.Universita degli Studi di Urbino Carlo Bo,University of Urbino (författare)
  • Santi, M.Universita degli Studi di Urbino Carlo Bo,University of Urbino (författare)
  • Gatto, Francesco,1987Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)gatto (författare)
  • Linhardt, R. J.Rensselaer Polytechnic Institute (författare)
  • Galeotti, F.Universita Degli Studi Di Modena E Reggio Emilia,University of Modena and Reggio Emilia (författare)
  • Volpi, N.Universita Degli Studi Di Modena E Reggio Emilia,University of Modena and Reggio Emilia (författare)
  • Universita degli Studi di Urbino Carlo BoUniversita Degli Studi Di Modena E Reggio Emilia (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Cell Biochemistry and Function: Wiley33:3, s. 128-1330263-64841099-0844

Internetlänk

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy