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The integration of ...
The integration of large-scale public data and network analysis uncovers molecular characteristics of psoriasis
- Artikel/kapitelEngelska2022
Förlag, utgivningsår, omfång ...
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2022-11-28
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Springer Science and Business Media LLC,2022
Nummerbeteckningar
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:151306902
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http://kipublications.ki.se/Default.aspx?queryparsed=id:151306902URI
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https://doi.org/10.1186/s40246-022-00431-xDOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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In recent years, a growing interest in the characterization of the molecular basis of psoriasis has been observed. However, despite the availability of a large amount of molecular data, many pathogenic mechanisms of psoriasis are still poorly understood. In this study, we performed an integrated analysis of 23 public transcriptomic datasets encompassing both lesional and uninvolved skin samples from psoriasis patients. We defined comprehensive gene co-expression network models of psoriatic lesions and uninvolved skin. Moreover, we curated and exploited a wide range of functional information from multiple public sources in order to systematically annotate the inferred networks. The integrated analysis of transcriptomics data and co-expression networks highlighted genes that are frequently dysregulated and show aberrant patterns of connectivity in the psoriatic lesion compared with the unaffected skin. Our approach allowed us to also identify plausible, previously unknown, actors in the expression of the psoriasis phenotype. Finally, we characterized communities of co-expressed genes associated with relevant molecular functions and expression signatures of specific immune cell types associated with the psoriasis lesion. Overall, integrating experimental driven results with curated functional information from public repositories represents an efficient approach to empower knowledge generation about psoriasis and may be applicable to other complex diseases.
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Pavel, A
(författare)
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Mobus, L
(författare)
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McKean, D
(författare)
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Del Giudice, G
(författare)
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Fortino, V
(författare)
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Niehues, H
(författare)
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Rastrick, J
(författare)
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Eyerich, KKarolinska Institutet
(författare)
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Eyerich, S
(författare)
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van den Bogaard, E
(författare)
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Smith, C
(författare)
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Weidinger, S
(författare)
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de Rinaldis, E
(författare)
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Greco, D
(författare)
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Karolinska Institutet
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Human genomics: Springer Science and Business Media LLC16:1, s. 62-1479-7364
Internetlänk
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Federico, A
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Pavel, A
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Mobus, L
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McKean, D
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Del Giudice, G
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Fortino, V
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visa fler...
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Niehues, H
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Rastrick, J
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Eyerich, K
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Eyerich, S
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van den Bogaard, ...
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Smith, C
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Weidinger, S
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de Rinaldis, E
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Greco, D
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visa färre...
- Artiklar i publikationen
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Human genomics
- Av lärosätet
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Karolinska Institutet