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Autoantibodies agai...
Autoantibodies against type I IFNs in patients with critical influenza pneumonia
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Zhang, Q (author)
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Pizzorno, A (author)
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Miorin, L (author)
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show more...
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Bastard, P (author)
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Gervais, A (author)
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Le Voyer, T (author)
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Bizien, L (author)
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Manry, J (author)
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Rosain, J (author)
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Philippot, Q (author)
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Goavec, K (author)
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Padey, B (author)
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Cupic, A (author)
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Laurent, E (author)
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Saker, K (author)
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Vanker, M (author)
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Sarekannu, K (author)
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Garcia-Salum, T (author)
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Ferres, M (author)
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Le Corre, N (author)
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Sanchez-Cespedes, J (author)
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Balsera-Manzanero, M (author)
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Carratala, J (author)
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Retamar-Gentil, P (author)
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Abelenda-Alonso, G (author)
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Valiente, A (author)
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Tiberghien, P (author)
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Zins, M (author)
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Debette, S (author)
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Meyts, I (author)
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Haerynck, F (author)
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Castagnoli, R (author)
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Notarangelo, LD (author)
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Gonzalez-Granado, LI (author)
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Dominguez-Pinilla, N (author)
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Andreakos, E (author)
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Triantafyllia, V (author)
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Rodriguez-Gallego, C (author)
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Sole-Violan, J (author)
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Ruiz-Hernandez, JJ (author)
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Rodriguez de Castro, F (author)
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Ferreres, J (author)
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Briones, M (author)
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Wauters, J (author)
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Vanderbeke, L (author)
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Feys, S (author)
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Kuo, CY (author)
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Lei, WT (author)
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Ku, CL (author)
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Tal, G (author)
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Etzioni, A (author)
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Hanna, S (author)
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Fournet, T (author)
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Casalegno, JS (author)
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Queromes, G (author)
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Argaud, L (author)
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Javouhey, E (author)
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Rosa-Calatrava, M (author)
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Cordero, E (author)
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Aydillo, T (author)
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Medina, RA (author)
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Kisand, K (author)
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Puel, A (author)
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Jouanguy, E (author)
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Abel, L (author)
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Cobat, A (author)
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Trouillet-Assant, S (author)
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Garcia-Sastre, A (author)
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Casanova, JL (author)
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- 2022-09-16
- 2022
- English.
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In: The Journal of experimental medicine. - : Rockefeller University Press. - 1540-9538 .- 0022-1007. ; 219:11
- Related links:
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http://kipublication...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Autoantibodies neutralizing type I interferons (IFNs) can underlie critical COVID-19 pneumonia and yellow fever vaccine disease. We report here on 13 patients harboring autoantibodies neutralizing IFN-α2 alone (five patients) or with IFN-ω (eight patients) from a cohort of 279 patients (4.7%) aged 6–73 yr with critical influenza pneumonia. Nine and four patients had antibodies neutralizing high and low concentrations, respectively, of IFN-α2, and six and two patients had antibodies neutralizing high and low concentrations, respectively, of IFN-ω. The patients’ autoantibodies increased influenza A virus replication in both A549 cells and reconstituted human airway epithelia. The prevalence of these antibodies was significantly higher than that in the general population for patients <70 yr of age (5.7 vs. 1.1%, P = 2.2 × 10−5), but not >70 yr of age (3.1 vs. 4.4%, P = 0.68). The risk of critical influenza was highest in patients with antibodies neutralizing high concentrations of both IFN-α2 and IFN-ω (OR = 11.7, P = 1.3 × 10−5), especially those <70 yr old (OR = 139.9, P = 3.1 × 10−10). We also identified 10 patients in additional influenza patient cohorts. Autoantibodies neutralizing type I IFNs account for ∼5% of cases of life-threatening influenza pneumonia in patients <70 yr old.
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Zhang, Q
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Pizzorno, A
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Miorin, L
-
Bastard, P
-
Gervais, A
-
Le Voyer, T
-
show more...
-
Bizien, L
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Manry, J
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Rosain, J
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Philippot, Q
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Goavec, K
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Padey, B
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Cupic, A
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Laurent, E
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Saker, K
-
Vanker, M
-
Sarekannu, K
-
Garcia-Salum, T
-
Ferres, M
-
Le Corre, N
-
Sanchez-Cespedes ...
-
Balsera-Manzaner ...
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Carratala, J
-
Retamar-Gentil, ...
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Abelenda-Alonso, ...
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Valiente, A
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Tiberghien, P
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Zins, M
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Debette, S
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Meyts, I
-
Haerynck, F
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Castagnoli, R
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Notarangelo, LD
-
Gonzalez-Granado ...
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Dominguez-Pinill ...
-
Andreakos, E
-
Triantafyllia, V
-
Rodriguez-Galleg ...
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Sole-Violan, J
-
Ruiz-Hernandez, ...
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Rodriguez de Cas ...
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Ferreres, J
-
Briones, M
-
Wauters, J
-
Vanderbeke, L
-
Feys, S
-
Kuo, CY
-
Lei, WT
-
Ku, CL
-
Tal, G
-
Etzioni, A
-
Hanna, S
-
Fournet, T
-
Casalegno, JS
-
Queromes, G
-
Argaud, L
-
Javouhey, E
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Rosa-Calatrava, ...
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Cordero, E
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Aydillo, T
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Medina, RA
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Kisand, K
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Puel, A
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Jouanguy, E
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Abel, L
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Cobat, A
-
Trouillet-Assant ...
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Garcia-Sastre, A
-
Casanova, JL
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show less...
- Articles in the publication
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The Journal of e ...
- By the university
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Karolinska Institutet