SwePub
Sök i LIBRIS databas

  Extended search

(WFRF:(Koup R))
 

Search: (WFRF:(Koup R)) > (2020-2022) > Vaccination induces...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • Leggat, DJ (author)

Vaccination induces HIV broadly neutralizing antibody precursors in humans

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • American Association for the Advancement of Science (AAAS),2022

Numbers

  • LIBRIS-ID:oai:prod.swepub.kib.ki.se:151565566
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:151565566URI
  • https://doi.org/10.1126/science.add6502DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:236454825URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:154904871URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Broadly neutralizing antibodies (bnAbs) can protect against HIV infection but have not been induced by human vaccination. A key barrier to bnAb induction is vaccine priming of rare bnAb-precursor B cells. In a randomized, double-blind, placebo-controlled phase 1 clinical trial, the HIV vaccine–priming candidate eOD-GT8 60mer adjuvanted with AS01Bhad a favorable safety profile and induced VRC01-class bnAb precursors in 97% of vaccine recipients with median frequencies reaching 0.1% among immunoglobulin G B cells in blood. bnAb precursors shared properties with bnAbs and gained somatic hypermutation and affinity with the boost. The results establish clinical proof of concept for germline-targeting vaccine priming, support development of boosting regimens to induce bnAbs, and encourage application of the germline-targeting strategy to other targets in HIV and other pathogens.

Added entries (persons, corporate bodies, meetings, titles ...)

  • Cohen, KW (author)
  • Willis, JR (author)
  • Fulp, WJ (author)
  • deCamp, AC (author)
  • Kalyuzhniy, O (author)
  • Cottrell, CA (author)
  • Menis, S (author)
  • Finak, G (author)
  • Ballweber-Fleming, L (author)
  • Srikanth, A (author)
  • Plyler, JR (author)
  • Schiffner, T (author)
  • Liguori, A (author)
  • Rahaman, F (author)
  • Lombardo, A (author)
  • Philiponis, V (author)
  • Whaley, RE (author)
  • Seese, A (author)
  • Brand, J (author)
  • Ruppel, AM (author)
  • Hoyland, W (author)
  • Yates, NL (author)
  • Williams, LD (author)
  • Greene, KKarolinska Institutet (author)
  • Gao, HM (author)
  • Mahoney, CR (author)
  • Corcoran, MMKarolinska Institutet (author)
  • Cagigi, A (author)
  • Taylor, A (author)
  • Brown, DM (author)
  • Ambrozak, DR (author)
  • Sincomb, T (author)
  • Hu, XZ (author)
  • Tingle, R (author)
  • Georgeson, E (author)
  • Eskandarzadeh, S (author)
  • Alavi, N (author)
  • Lu, D (author)
  • Mullen, TM (author)
  • Kubitz, M (author)
  • Groschel, B (author)
  • Maenza, J (author)
  • Kolokythas, O (author)
  • Khati, N (author)
  • Bethony, J (author)
  • Crotty, S (author)
  • Roederer, M (author)
  • Hedestam, GBKKarolinska Institutet (author)
  • Tomaras, GD (author)
  • Montefiori, D (author)
  • Diemert, D (author)
  • Koup, RA (author)
  • Laufer, DS (author)
  • McElrath, MJ (author)
  • McDermott, AB (author)
  • Schief, WR (author)
  • Karolinska Institutet (creator_code:org_t)

Related titles

  • In:Science (New York, N.Y.): American Association for the Advancement of Science (AAAS)378:6623, s. 964-+1095-92030036-8075

Internet link

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view