SwePub
Sök i LIBRIS databas

  Extended search

WFRF:(Lum L)
 

Search: WFRF:(Lum L) > Notch-dependent coo...

  • Kvedaraite, EKarolinska Institutet (author)

Notch-dependent cooperativity between myeloid lineages promotes Langerhans cell histiocytosis pathology

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • American Association for the Advancement of Science (AAAS),2022

Numbers

  • LIBRIS-ID:oai:prod.swepub.kib.ki.se:151961734
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:151961734URI
  • https://doi.org/10.1126/sciimmunol.add3330DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Langerhans cell histiocytosis (LCH) is a potentially fatal neoplasm characterized by the aberrant differentiation of mononuclear phagocytes, driven by mitogen-activated protein kinase (MAPK) pathway activation. LCH cells may trigger destructive pathology yet remain in a precarious state finely balanced between apoptosis and survival, supported by a unique inflammatory milieu. The interactions that maintain this state are not well known and may offer targets for intervention. Here, we used single-cell RNA-seq and protein analysis to dissect LCH lesions, assessing LCH cell heterogeneity and comparing LCH cells with normal mononuclear phagocytes within lesions. We found LCH discriminatory signatures pointing to senescence and escape from tumor immune surveillance. We also uncovered two major lineages of LCH with DC2- and DC3/monocyte-like phenotypes and validated them in multiple pathological tissue sites by high-content imaging. Receptor-ligand analyses and lineage tracing in vitro revealed Notch-dependent cooperativity between DC2 and DC3/monocyte lineages during expression of the pathognomonic LCH program. Our results present a convergent dual origin model of LCH with MAPK pathway activation occurring before fate commitment to DC2 and DC3/monocyte lineages and Notch-dependent cooperativity between lineages driving the development of LCH cells.

Added entries (persons, corporate bodies, meetings, titles ...)

  • Milne, P (author)
  • Khalilnezhad, A (author)
  • Chevrier, M (author)
  • Sethi, R (author)
  • Lee, HK (author)
  • Hagey, DWKarolinska Institutet (author)
  • Greenwood, TVKarolinska Institutet (author)
  • Mouratidou, N (author)
  • Jadersten, MKarolinska Institutet (author)
  • Lee, NYS (author)
  • Minnerup, L (author)
  • Tan, YR (author)
  • Dutertre, CA (author)
  • Benac, N (author)
  • Hwang, YY (author)
  • Lum, J (author)
  • Loh, AHP (author)
  • Jansson, J (author)
  • Teng, KWW (author)
  • Khalilnezhad, S (author)
  • Xu, WL (author)
  • Resteu, A (author)
  • Tey, HL (author)
  • Guan, NL (author)
  • Larbi, A (author)
  • Howland, SW (author)
  • Arnell, HKarolinska Institutet (author)
  • Andaloussi, SELKarolinska Institutet (author)
  • Braier, J (author)
  • Rassidakis, GKarolinska Institutet (author)
  • Galluzzo, L (author)
  • Dzionek, A (author)
  • Henter, JIKarolinska Institutet (author)
  • Chen, JM (author)
  • Collin, M (author)
  • Ginhoux, F (author)
  • Karolinska Institutet (creator_code:org_t)

Related titles

  • In:Science immunology: American Association for the Advancement of Science (AAAS)7:78, s. eadd3330-2470-9468

Internet link

Find in a library

To the university's database

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view