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Islet Autoantibody ...
Islet Autoantibody Levels Differentiate Progression Trajectories in Individuals with Presymptomatic Type 1 Diabetes
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- Kwon, Bum Chul (author)
- IBM Research Cambridge
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- Achenbach, Peter (author)
- Helmholtz Zentrum München
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- Anand, Vibha (author)
- IBM Research Cambridge
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- Frohnert, Brigitte I (author)
- University of Colorado
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- Hagopian, William (author)
- Pacific Northwest Research Institute
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- Hu, Jianying (author)
- IBM Research
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- Koski, Eileen (author)
- IBM Research
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- Lernmark, Åke (author)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups,Skåne University Hospital
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- Lou, Olivia (author)
- Juvenile Diabetes Research Foundation
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- Martin, Frank (author)
- Juvenile Diabetes Research Foundation
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- Ng, Kenney (author)
- IBM Research Cambridge
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- Toppari, Jorma (author)
- University of Oulu
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- Veijola, Riitta (author)
- Oulu University Hospital,University of Oulu
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(creator_code:org_t)
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- 2022-09-16
- 2022
- English.
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In: Diabetes. - : American Diabetes Association. - 1939-327X .- 0012-1797. ; 71:12, s. 2632-2641
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http://dx.doi.org/10...
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Abstract
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- Our previous data-driven analysis of evolving patterns of islet autoantibodies (IAbs) against insulin (IAA), glutamic acid decarboxylase (GADA) and islet antigen 2 (IA-2A) discovered three trajectories characterized by either multiple IAbs (TR1), IAA (TR2), or GADA (TR3) as the first appearing autoantibodies. Here we examined the evolution of IAb levels within these trajectories in 2,145 IAb-positive participants followed from early life and compared those who progressed to type 1 diabetes (n=643) to those remaining undiagnosed (n=1,502). Using thresholds determined by 5-year diabetes risk, four levels were defined for each IAb and overlayed onto each visit. In diagnosed participants, high IAA levels were seen in TR1 and TR2 at ages <3 years, whereas IAA remained at lower levels in the undiagnosed. Proportions of dwell times (total duration of follow-up at a given level) at the four IAb levels differed between the diagnosed and undiagnosed for GADA and IA-2A in all three trajectories (p<0.001), but for IAA dwell times differed only within TR2 (p<0.05). Overall, undiagnosed participants more frequently had low IAb levels and later appearance of IAb than diagnosed participants. In conclusion, while it has been long appreciated that the number of autoantibodies is an important predictor of type 1 diabetes, consideration of autoantibody levels within the three autoimmune trajectories improved differentiation of IAb positive children who progressed to type 1 diabetes from those who did not.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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Diabetes
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- By the author/editor
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Kwon, Bum Chul
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Achenbach, Peter
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Anand, Vibha
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Frohnert, Brigit ...
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Hagopian, Willia ...
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Hu, Jianying
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show more...
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Koski, Eileen
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Lernmark, Åke
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Lou, Olivia
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Martin, Frank
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Ng, Kenney
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Toppari, Jorma
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Veijola, Riitta
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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Diabetes
- By the university
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Lund University