Vaccine breakthrough hypoxemic COVID-19 pneumonia in patients with auto-Abs neutralizing type I IFNs

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MARC

Bastard, P (author)

Vaccine breakthrough hypoxemic COVID-19 pneumonia in patients with auto-Abs neutralizing type I IFNs

Article/chapterEnglish2022

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2022-06-14
American Association for the Advancement of Science (AAAS),2022

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LIBRIS-ID:oai:prod.swepub.kib.ki.se:151941823
http://kipublications.ki.se/Default.aspx?queryparsed=id:151941823URI
https://doi.org/10.1126/sciimmunol.abp8966DOI

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Language:English
Summary in:English

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Life-threatening ‘breakthrough’ cases of critical COVID-19 are attributed to poor or waning antibody response to the SARS-CoV-2 vaccine in individuals already at risk. Pre-existing autoantibodies (auto-Abs) neutralizing type I IFNs underlie at least 15% of critical COVID-19 pneumonia cases in unvaccinated individuals; however, their contribution to hypoxemic breakthrough cases in vaccinated people remains unknown. Here, we studied a cohort of 48 individuals (age 20-86 years) who received 2 doses of an mRNA vaccine and developed a breakthrough infection with hypoxemic COVID-19 pneumonia 2 weeks to 4 months later. Antibody levels to the vaccine, neutralization of the virus, and auto-Abs to type I IFNs were measured in the plasma. Forty-two individuals had no known deficiency of B cell immunity and a normal antibody response to the vaccine. Among them, ten (24%) had auto-Abs neutralizing type I IFNs (aged 43-86 years). Eight of these ten patients had auto-Abs neutralizing both IFN-α2 and IFN-ω, while two neutralized IFN-ω only. No patient neutralized IFN-β. Seven neutralized 10 ng/mL of type I IFNs, and three 100 pg/mL only. Seven patients neutralized SARS-CoV-2 D614G and the Delta variant (B.1.617.2) efficiently, while one patient neutralized Delta slightly less efficiently. Two of the three patients neutralizing only 100 pg/mL of type I IFNs neutralized both D61G and Delta less efficiently. Despite two mRNA vaccine inoculations and the presence of circulating antibodies capable of neutralizing SARS-CoV-2, auto-Abs neutralizing type I IFNs may underlie a significant proportion of hypoxemic COVID-19 pneumonia cases, highlighting the importance of this particularly vulnerable population.

Added entries (persons, corporate bodies, meetings, titles ...)

Vazquez, S (author)
Liu, J (author)
Laurie, MT (author)
Wang, CY (author)
Gervais, A (author)
Le Voyer, T (author)
Bizien, L (author)
Zamecnik, C (author)
Philippot, Q (author)
Rosain, J (author)
Catherinot, E (author)
Willmore, A (author)
Mitchell, AM (author)
Bair, R (author)
Garcon, P (author)
Kenney, H (author)
Fekkar, A (author)
Salagianni, M (author)
Poulakou, G (author)
Siouti, E (author)
Sahanic, S (author)
Tancevski, I (author)
Weiss, G (author)
Nagl, L (author)
Manry, J (author)
Duvlis, S (author)
Arroyo-Sanchez, D (author)
Artal, EP (author)
Rubio, L (author)
Perani, C (author)
Bezzi, M (author)
Sottini, A (author)
Quaresima, V (author)
Roussel, L (author)
Vinh, DC (author)
Reyes, LF (author)
Garzaro, M (author)
Hatipoglu, N (author)
Boutboul, D (author)
Tandjaoui-Lambiotte, Y (author)
Borghesi, A (author)
Aliberti, A (author)
Cassaniti, I (author)
Venet, F (author)
Monneret, G (author)
Halwani, R (author)
Sharif-Askari, NS (author)
Danielson, J (author)
Burrel, S (author)
Morbieu, C (author)
Stepanovskyy, Y (author)
Bondarenko, A (author)
Volokha, A (author)
Boyarchuk, O (author)
Gagro, A (author)
Neuville, M (author)
Neven, B (author)
Keles, S (author)
Hernu, R (author)
Bal, A (author)
Novelli, A (author)
Novelli, G (author)
Saker, K (author)
Ailioaie, O (author)
Antoli, A (author)
Jeziorski, E (author)
Rocamora-Blanch, G (author)
Teixeira, C (author)
Delaunay, C (author)
Lhuillier, M (author)
Le Turnier, P (author)
Zhang, Y (author)
Mahevas, M (author)
Pan-Hammarstrom, QKarolinska Institutet (author)
Abolhassani, HKarolinska Institutet (author)
Bompoil, T (author)
Dorgham, K (author)
Group, FCS (author)
Gorochov, G (author)
Laouenan, C (author)
Rodriguez-Gallego, C (author)
Ng, LFP (author)
Renia, L (author)
Pujol, A (author)
Belot, A (author)
Raffi, F (author)
Allende, LM (author)
Martinez-Picado, J (author)
Ozcelik, T (author)
Keles, S (author)
Imberti, L (author)
Notarangelo, LD (author)
Troya, J (author)
Solanich, X (author)
Zhang, SY (author)
Puel, A (author)
Wilson, MR (author)
Trouillet-Assants, S (author)
Abe, L (author)
Jouanguy, E (author)
Ye, CJ (author)
Cobat, A (author)
Thompson, LM (author)
Andreakos, E (author)
Zhang, Q (author)
Anderson, MS (author)
Casanova, JL (author)
DeRisi, JL (author)
Karolinska Institutet (creator_code:org_t)

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In:Science immunology: American Association for the Advancement of Science (AAAS)78:7490, s. eabp8966-2470-9468

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By the author/editor: Bastard, P; Vazquez, S; Liu, J; Laurie, MT; Wang, CY; Gervais, A; show more...; Le Voyer, T; Bizien, L; Zamecnik, C; Philippot, Q; Rosain, J; Catherinot, E; Willmore, A; Mitchell, AM; Bair, R; Garcon, P; Kenney, H; Fekkar, A; Salagianni, M; Poulakou, G; Siouti, E; Sahanic, S; Tancevski, I; Weiss, G; Nagl, L; Manry, J; Duvlis, S; Arroyo-Sanchez, ...; Artal, EP; Rubio, L; Perani, C; Bezzi, M; Sottini, A; Quaresima, V; Roussel, L; Vinh, DC; Reyes, LF; Garzaro, M; Hatipoglu, N; Boutboul, D; Tandjaoui-Lambio ...; Borghesi, A; Aliberti, A; Cassaniti, I; Venet, F; Monneret, G; Halwani, R; Sharif-Askari, N ...; Danielson, J; Burrel, S; Morbieu, C; Stepanovskyy, Y; Bondarenko, A; Volokha, A; Boyarchuk, O; Gagro, A; Neuville, M; Neven, B; Keles, S; Hernu, R; Bal, A; Novelli, A; Novelli, G; Saker, K; Ailioaie, O; Antoli, A; Jeziorski, E; Rocamora-Blanch, ...; Teixeira, C; Delaunay, C; Lhuillier, M; Le Turnier, P; Zhang, Y; Mahevas, M; Pan-Hammarstrom, ...; Abolhassani, H; Bompoil, T; Dorgham, K; Group, FCS; Gorochov, G; Laouenan, C; Rodriguez-Galleg ...; Ng, LFP; Renia, L; Pujol, A; Belot, A; Raffi, F; Allende, LM; Martinez-Picado, ...; Ozcelik, T; Imberti, L; Notarangelo, LD; Troya, J; Solanich, X; Zhang, SY; Puel, A; Wilson, MR; Trouillet-Assant ...; Abe, L; Jouanguy, E; Ye, CJ; Cobat, A; Thompson, LM; Andreakos, E; Zhang, Q; Anderson, MS; Casanova, JL; DeRisi, JL; show less...

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