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Vaccine breakthroug...
Vaccine breakthrough hypoxemic COVID-19 pneumonia in patients with auto-Abs neutralizing type I IFNs
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Bastard, P (author)
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Vazquez, S (author)
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Liu, J (author)
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show more...
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Laurie, MT (author)
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Wang, CY (author)
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Gervais, A (author)
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Le Voyer, T (author)
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Bizien, L (author)
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Zamecnik, C (author)
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Philippot, Q (author)
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Rosain, J (author)
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Catherinot, E (author)
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Willmore, A (author)
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Mitchell, AM (author)
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Bair, R (author)
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Garcon, P (author)
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Kenney, H (author)
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Fekkar, A (author)
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Salagianni, M (author)
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Poulakou, G (author)
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Siouti, E (author)
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Sahanic, S (author)
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Tancevski, I (author)
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Weiss, G (author)
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Nagl, L (author)
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Manry, J (author)
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Duvlis, S (author)
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Arroyo-Sanchez, D (author)
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Artal, EP (author)
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Rubio, L (author)
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Perani, C (author)
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Bezzi, M (author)
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Sottini, A (author)
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Quaresima, V (author)
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Roussel, L (author)
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Vinh, DC (author)
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Reyes, LF (author)
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Garzaro, M (author)
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Hatipoglu, N (author)
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Boutboul, D (author)
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Tandjaoui-Lambiotte, Y (author)
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Borghesi, A (author)
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Aliberti, A (author)
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Cassaniti, I (author)
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Venet, F (author)
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Monneret, G (author)
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Halwani, R (author)
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Sharif-Askari, NS (author)
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Danielson, J (author)
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Burrel, S (author)
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Morbieu, C (author)
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Stepanovskyy, Y (author)
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Bondarenko, A (author)
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Volokha, A (author)
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Boyarchuk, O (author)
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Gagro, A (author)
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Neuville, M (author)
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Neven, B (author)
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Keles, S (author)
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Hernu, R (author)
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Bal, A (author)
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Novelli, A (author)
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Novelli, G (author)
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Saker, K (author)
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Ailioaie, O (author)
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Antoli, A (author)
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Jeziorski, E (author)
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Rocamora-Blanch, G (author)
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Teixeira, C (author)
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Delaunay, C (author)
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Lhuillier, M (author)
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Le Turnier, P (author)
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Zhang, Y (author)
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Mahevas, M (author)
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- Pan-Hammarstrom, Q (author)
- Karolinska Institutet
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- Abolhassani, H (author)
- Karolinska Institutet
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Bompoil, T (author)
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Dorgham, K (author)
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Group, FCS (author)
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Gorochov, G (author)
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Laouenan, C (author)
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Rodriguez-Gallego, C (author)
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Ng, LFP (author)
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Renia, L (author)
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Pujol, A (author)
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Belot, A (author)
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Raffi, F (author)
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Allende, LM (author)
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Martinez-Picado, J (author)
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Ozcelik, T (author)
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Keles, S (author)
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Imberti, L (author)
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Notarangelo, LD (author)
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Troya, J (author)
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Solanich, X (author)
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Zhang, SY (author)
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Puel, A (author)
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Wilson, MR (author)
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Trouillet-Assants, S (author)
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Abe, L (author)
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Jouanguy, E (author)
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Ye, CJ (author)
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Cobat, A (author)
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Thompson, LM (author)
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Andreakos, E (author)
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Zhang, Q (author)
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Anderson, MS (author)
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Casanova, JL (author)
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DeRisi, JL (author)
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(creator_code:org_t)
- 2022-06-14
- 2022
- English.
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In: Science immunology. - : American Association for the Advancement of Science (AAAS). - 2470-9468. ; 78:7490, s. eabp8966-
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Life-threatening ‘breakthrough’ cases of critical COVID-19 are attributed to poor or waning antibody response to the SARS-CoV-2 vaccine in individuals already at risk. Pre-existing autoantibodies (auto-Abs) neutralizing type I IFNs underlie at least 15% of critical COVID-19 pneumonia cases in unvaccinated individuals; however, their contribution to hypoxemic breakthrough cases in vaccinated people remains unknown. Here, we studied a cohort of 48 individuals (age 20-86 years) who received 2 doses of an mRNA vaccine and developed a breakthrough infection with hypoxemic COVID-19 pneumonia 2 weeks to 4 months later. Antibody levels to the vaccine, neutralization of the virus, and auto-Abs to type I IFNs were measured in the plasma. Forty-two individuals had no known deficiency of B cell immunity and a normal antibody response to the vaccine. Among them, ten (24%) had auto-Abs neutralizing type I IFNs (aged 43-86 years). Eight of these ten patients had auto-Abs neutralizing both IFN-α2 and IFN-ω, while two neutralized IFN-ω only. No patient neutralized IFN-β. Seven neutralized 10 ng/mL of type I IFNs, and three 100 pg/mL only. Seven patients neutralized SARS-CoV-2 D614G and the Delta variant (B.1.617.2) efficiently, while one patient neutralized Delta slightly less efficiently. Two of the three patients neutralizing only 100 pg/mL of type I IFNs neutralized both D61G and Delta less efficiently. Despite two mRNA vaccine inoculations and the presence of circulating antibodies capable of neutralizing SARS-CoV-2, auto-Abs neutralizing type I IFNs may underlie a significant proportion of hypoxemic COVID-19 pneumonia cases, highlighting the importance of this particularly vulnerable population.
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
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- By the author/editor
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Bastard, P
-
Vazquez, S
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Liu, J
-
Laurie, MT
-
Wang, CY
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Gervais, A
-
show more...
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Le Voyer, T
-
Bizien, L
-
Zamecnik, C
-
Philippot, Q
-
Rosain, J
-
Catherinot, E
-
Willmore, A
-
Mitchell, AM
-
Bair, R
-
Garcon, P
-
Kenney, H
-
Fekkar, A
-
Salagianni, M
-
Poulakou, G
-
Siouti, E
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Sahanic, S
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Tancevski, I
-
Weiss, G
-
Nagl, L
-
Manry, J
-
Duvlis, S
-
Arroyo-Sanchez, ...
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Artal, EP
-
Rubio, L
-
Perani, C
-
Bezzi, M
-
Sottini, A
-
Quaresima, V
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Roussel, L
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Vinh, DC
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Reyes, LF
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Garzaro, M
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Hatipoglu, N
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Boutboul, D
-
Tandjaoui-Lambio ...
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Borghesi, A
-
Aliberti, A
-
Cassaniti, I
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Venet, F
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Monneret, G
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Halwani, R
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Sharif-Askari, N ...
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Danielson, J
-
Burrel, S
-
Morbieu, C
-
Stepanovskyy, Y
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Bondarenko, A
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Volokha, A
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Boyarchuk, O
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Gagro, A
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Neuville, M
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Neven, B
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Keles, S
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Hernu, R
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Bal, A
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Novelli, A
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Novelli, G
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Saker, K
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Ailioaie, O
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Antoli, A
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Jeziorski, E
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Rocamora-Blanch, ...
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Teixeira, C
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Delaunay, C
-
Lhuillier, M
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Le Turnier, P
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Zhang, Y
-
Mahevas, M
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Pan-Hammarstrom, ...
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Abolhassani, H
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Bompoil, T
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Dorgham, K
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Group, FCS
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Gorochov, G
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Laouenan, C
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Rodriguez-Galleg ...
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Ng, LFP
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Renia, L
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Pujol, A
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Belot, A
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Raffi, F
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Allende, LM
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Martinez-Picado, ...
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Ozcelik, T
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Imberti, L
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Notarangelo, LD
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Troya, J
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Solanich, X
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Zhang, SY
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Puel, A
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Wilson, MR
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Trouillet-Assant ...
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Abe, L
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Jouanguy, E
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Ye, CJ
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Cobat, A
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Thompson, LM
-
Andreakos, E
-
Zhang, Q
-
Anderson, MS
-
Casanova, JL
-
DeRisi, JL
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show less...
- Articles in the publication
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Science immunolo ...
- By the university
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Karolinska Institutet