Search: WFRF:(Nunes SL)
> (2023) >
Adverse maternal, f...
Adverse maternal, fetal, and newborn outcomes among pregnant women with SARS-CoV-2 infection: an individual participant data meta-analysis
- Article/chapterEnglish2023
Publisher, publication year, extent ...
Numbers
-
LIBRIS-ID:oai:prod.swepub.kib.ki.se:152011311
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:152011311URI
-
https://doi.org/10.1136/bmjgh-2022-009495DOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
Despite a growing body of research on the risks of SARS-CoV-2 infection during pregnancy, there is continued controversy given heterogeneity in the quality and design of published studies.MethodsWe screened ongoing studies in our sequential, prospective meta-analysis. We pooled individual participant data to estimate the absolute and relative risk (RR) of adverse outcomes among pregnant women with SARS-CoV-2 infection, compared with confirmed negative pregnancies. We evaluated the risk of bias using a modified Newcastle-Ottawa Scale.ResultsWe screened 137 studies and included 12 studies in 12 countries involving 13 136 pregnant women.Pregnant women with SARS-CoV-2 infection—as compared with uninfected pregnant women—were at significantly increased risk of maternal mortality (10 studies; n=1490; RR 7.68, 95% CI 1.70 to 34.61); admission to intensive care unit (8 studies; n=6660; RR 3.81, 95% CI 2.03 to 7.17); receiving mechanical ventilation (7 studies; n=4887; RR 15.23, 95% CI 4.32 to 53.71); receiving any critical care (7 studies; n=4735; RR 5.48, 95% CI 2.57 to 11.72); and being diagnosed with pneumonia (6 studies; n=4573; RR 23.46, 95% CI 3.03 to 181.39) and thromboembolic disease (8 studies; n=5146; RR 5.50, 95% CI 1.12 to 27.12).Neonates born to women with SARS-CoV-2 infection were more likely to be admitted to a neonatal care unit after birth (7 studies; n=7637; RR 1.86, 95% CI 1.12 to 3.08); be born preterm (7 studies; n=6233; RR 1.71, 95% CI 1.28 to 2.29) or moderately preterm (7 studies; n=6071; RR 2.92, 95% CI 1.88 to 4.54); and to be born low birth weight (12 studies; n=11 930; RR 1.19, 95% CI 1.02 to 1.40). Infection was not linked to stillbirth. Studies were generally at low or moderate risk of bias.ConclusionsThis analysis indicates that SARS-CoV-2 infection at any time during pregnancy increases the risk of maternal death, severe maternal morbidities and neonatal morbidity, but not stillbirth or intrauterine growth restriction. As more data become available, we will update these findings per the published protocol.
Added entries (persons, corporate bodies, meetings, titles ...)
-
Oakley, E
(author)
-
Grandner, GW
(author)
-
Ferguson, K
(author)
-
Farooq, F
(author)
-
Afshar, Y
(author)
-
Ahlberg, MKarolinska Institutet
(author)
-
Ahmadzia, H
(author)
-
Akelo, V
(author)
-
Aldrovandi, G
(author)
-
Barr, BAT
(author)
-
Bevilacqua, E
(author)
-
Brandt, JS
(author)
-
Broutet, N
(author)
-
Buhigas, IF
(author)
-
Carrillo, J
(author)
-
Clifton, R
(author)
-
Conry, J
(author)
-
Cosmi, E
(author)
-
Crispi, F
(author)
-
Crovetto, F
(author)
-
Delgado-Lopez, C
(author)
-
Divakar, H
(author)
-
Driscoll, AJ
(author)
-
Favre, G
(author)
-
Flaherman, VJ
(author)
-
Gale, C
(author)
-
Gil, MM
(author)
-
Gottlieb, SL
(author)
-
Gratacos, E
(author)
-
Hernandez, O
(author)
-
Jones, S
(author)
-
Kalafat, E
(author)
-
Khagayi, S
(author)
-
Knight, M
(author)
-
Kotloff, K
(author)
-
Lanzone, A
(author)
-
Le Doare, K
(author)
-
Lees, C
(author)
-
Litman, E
(author)
-
Lokken, EM
(author)
-
Longo, VL
(author)
-
Madhi, SA
(author)
-
Magee, LA
(author)
-
Martinez-Portilla, RJ
(author)
-
McClure, EM
(author)
-
Metz, TD
(author)
-
Miller, ES
(author)
-
Money, D
(author)
-
Moungmaithong, S
(author)
-
Mullins, E
(author)
-
Nachega, JB
(author)
-
Nunes, MC
(author)
-
Onyango, D
(author)
-
Panchaud, A
(author)
-
Poon, LC
(author)
-
Raiten, D
(author)
-
Regan, L
(author)
-
Rukundo, G
(author)
-
Sahota, D
(author)
-
Sakowicz, A
(author)
-
Sanin-Blair, J
(author)
-
Soderling, JKarolinska Institutet
(author)
-
Stephansson, OKarolinska Institutet
(author)
-
Temmerman, M
(author)
-
Thorson, A
(author)
-
Tolosa, JE
(author)
-
Townson, J
(author)
-
Valencia-Prado, M
(author)
-
Visentin, S
(author)
-
von Dadelszen, P
(author)
-
Waldorf, KA
(author)
-
Whitehead, C
(author)
-
Yassa, M
(author)
-
Tielsch, JM
(author)
-
Karolinska Institutet
(creator_code:org_t)
Related titles
-
In:BMJ global health: BMJ8:12059-7908
Internet link
Find in a library
To the university's database
- By the author/editor
-
Smith, ER
-
Oakley, E
-
Grandner, GW
-
Ferguson, K
-
Farooq, F
-
Afshar, Y
-
show more...
-
Ahlberg, M
-
Ahmadzia, H
-
Akelo, V
-
Aldrovandi, G
-
Barr, BAT
-
Bevilacqua, E
-
Brandt, JS
-
Broutet, N
-
Buhigas, IF
-
Carrillo, J
-
Clifton, R
-
Conry, J
-
Cosmi, E
-
Crispi, F
-
Crovetto, F
-
Delgado-Lopez, C
-
Divakar, H
-
Driscoll, AJ
-
Favre, G
-
Flaherman, VJ
-
Gale, C
-
Gil, MM
-
Gottlieb, SL
-
Gratacos, E
-
Hernandez, O
-
Jones, S
-
Kalafat, E
-
Khagayi, S
-
Knight, M
-
Kotloff, K
-
Lanzone, A
-
Le Doare, K
-
Lees, C
-
Litman, E
-
Lokken, EM
-
Longo, VL
-
Madhi, SA
-
Magee, LA
-
Martinez-Portill ...
-
McClure, EM
-
Metz, TD
-
Miller, ES
-
Money, D
-
Moungmaithong, S
-
Mullins, E
-
Nachega, JB
-
Nunes, MC
-
Onyango, D
-
Panchaud, A
-
Poon, LC
-
Raiten, D
-
Regan, L
-
Rukundo, G
-
Sahota, D
-
Sakowicz, A
-
Sanin-Blair, J
-
Soderling, J
-
Stephansson, O
-
Temmerman, M
-
Thorson, A
-
Tolosa, JE
-
Townson, J
-
Valencia-Prado, ...
-
Visentin, S
-
von Dadelszen, P
-
Waldorf, KA
-
Whitehead, C
-
Yassa, M
-
Tielsch, JM
-
show less...
- Articles in the publication
-
BMJ global healt ...
- By the university
-
Karolinska Institutet