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Multicenter Interna...
Multicenter International Study of the Consensus Immunoscore for the Prediction of Relapse and Survival in Early-Stage Colon Cancer
- Article/chapterEnglish2023
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:152057611
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http://kipublications.ki.se/Default.aspx?queryparsed=id:152057611URI
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https://doi.org/10.3390/cancers15020418DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Background: The prognostic value of Immunoscore was evaluated in Stage II/III colon cancer (CC) patients, but it remains unclear in Stage I/II, and in early-stage subgroups at risk. An international Society for Immunotherapy of Cancer (SITC) study evaluated the pre-defined consensus Immunoscore in tumors from 1885 AJCC/UICC-TNM Stage I/II CC patients from Canada/USA (Cohort 1) and Europe/Asia (Cohort 2). METHODS: Digital-pathology is used to quantify the densities of CD3+ and CD8+ T-lymphocyte in the center of tumor (CT) and the invasive margin (IM). The time to recurrence (TTR) was the primary endpoint. Secondary endpoints were disease-free survival (DFS), overall survival (OS), prognosis in Stage I, Stage II, Stage II-high-risk, and microsatellite-stable (MSS) patients. RESULTS: High-Immunoscore presented with the lowest risk of recurrence in both cohorts. In Stage I/II, recurrence-free rates at 5 years were 78.4% (95%-CI, 74.4–82.6), 88.1% (95%-CI, 85.7–90.4), 93.4% (95%-CI, 91.1–95.8) in low, intermediate and high Immunoscore, respectively (HR (Hi vs. Lo) = 0.27 (95%-CI, 0.18–0.41); p < 0.0001). In Cox multivariable analysis, the association of Immunoscore to outcome was independent (TTR: HR (Hi vs. Lo) = 0.29, (95%-CI, 0.17–0.50); p < 0.0001) of the patient’s gender, T-stage, sidedness, and microsatellite instability-status (MSI). A significant association of Immunoscore with survival was found for Stage II, high-risk Stage II, T4N0 and MSS patients. The Immunoscore also showed significant association with TTR in Stage-I (HR (Hi vs. Lo) = 0.07 (95%-CI, 0.01–0.61); P = 0.016). The Immunoscore had the strongest (69.5%) contribution χ2 for influencing survival. Patients with a high Immunoscore had prolonged TTR in T4N0 tumors even for patients not receiving chemotherapy, and the Immunoscore remained the only significant parameter in multivariable analysis. CONCLUSION: In early CC, low Immunoscore reliably identifies patients at risk of relapse for whom a more intensive surveillance program or adjuvant treatment should be considered.
Added entries (persons, corporate bodies, meetings, titles ...)
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Lugli, A
(author)
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Bindea, G
(author)
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Marliot, F
(author)
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Bifulco, C
(author)
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Lee, JKJ
(author)
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Zlobec, I
(author)
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Rau, TT
(author)
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Berger, MD
(author)
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Nagtegaal, ID
(author)
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Vink-Borger, E
(author)
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Hartmann, A
(author)
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Geppert, C
(author)
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Kolwelter, J
(author)
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Merkel, S
(author)
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Grutzmann, R
(author)
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Van den Eynde, M
(author)
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Jouret-Mourin, A
(author)
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Kartheuser, A
(author)
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Leonard, D
(author)
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Remue, C
(author)
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Wang, J
(author)
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Bavi, P
(author)
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Roehrl, MHA
(author)
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Ohashi, PS
(author)
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Nguyen, LT
(author)
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Han, S
(author)
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MacGregor, HL
(author)
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Hafezi-Bakhtiari, S
(author)
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Wouters, BG
(author)
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Masucci, GKarolinska Institutet
(author)
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Andersson, EK
(author)
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Zavadova, E
(author)
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Vocka, M
(author)
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Spacek, J
(author)
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Petruzelka, L
(author)
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Konopasek, B
(author)
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Dundr, P
(author)
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Skalova, H
(author)
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Nemejcova, K
(author)
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Botti, G
(author)
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Tatangelo, F
(author)
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Delrio, P
(author)
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Ciliberto, G
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Maio, M
(author)
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Laghi, L
(author)
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Grizzi, F
(author)
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Fredriksen, T
(author)
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Buttard, B
(author)
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Lafontaine, L
(author)
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Maby, P
(author)
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Majdi, A
(author)
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Hijazi, A
(author)
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El Sissy, C
(author)
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Kirilovsky, A
(author)
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Berger, A
(author)
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Lagorce, C
(author)
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Paustian, C
(author)
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Ballesteros-Merino, C
(author)
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Dijkstra, J
(author)
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van de Water, C
(author)
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Van Lent-van Vliet, S
(author)
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Knijn, N
(author)
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Musing, AM
(author)
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Scripcariu, DV
(author)
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Popivanova, B
(author)
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Xu, ML
(author)
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Fujita, T
(author)
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Hazama, S
(author)
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Suzuki, N
(author)
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Nagano, H
(author)
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Okuno, K
(author)
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Torigoe, T
(author)
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Sato, N
(author)
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Furuhata, T
(author)
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Takemasa, I
(author)
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Patel, P
(author)
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Vora, HH
(author)
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Shah, B
(author)
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Patel, JB
(author)
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Rajvik, KN
(author)
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Pandya, SJ
(author)
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Shukla, SN
(author)
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Wang, YL
(author)
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Zhang, GJ
(author)
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Kawakami, Y
(author)
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Marincola, FM
(author)
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Ascierto, PA
(author)
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Fox, BA
(author)
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Pages, F
(author)
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Galon, J
(author)
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Karolinska Institutet
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Mlecnik, B
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Lugli, A
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Bindea, G
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Bifulco, C
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Zlobec, I
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Rau, TT
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Hartmann, A
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Geppert, C
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Kolwelter, J
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Merkel, S
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Grutzmann, R
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Van den Eynde, M
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Jouret-Mourin, A
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Kartheuser, A
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Leonard, D
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Remue, C
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Wang, J
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Bavi, P
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Roehrl, MHA
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Ohashi, PS
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Nguyen, LT
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Han, S
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MacGregor, HL
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Hafezi-Bakhtiari ...
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Wouters, BG
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Masucci, G
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Andersson, EK
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Zavadova, E
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Vocka, M
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Spacek, J
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Petruzelka, L
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Konopasek, B
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Dundr, P
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Skalova, H
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Nemejcova, K
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Botti, G
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Tatangelo, F
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Delrio, P
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Ciliberto, G
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Maio, M
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Laghi, L
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Grizzi, F
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Fredriksen, T
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Buttard, B
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Lafontaine, L
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Maby, P
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Majdi, A
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Hijazi, A
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El Sissy, C
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Kirilovsky, A
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Berger, A
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Lagorce, C
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Paustian, C
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Ballesteros-Meri ...
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Dijkstra, J
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van de Water, C
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Van Lent-van Vli ...
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Knijn, N
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Musing, AM
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Scripcariu, DV
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Popivanova, B
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Xu, ML
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Fujita, T
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Hazama, S
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Suzuki, N
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Nagano, H
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Okuno, K
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Torigoe, T
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Sato, N
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Furuhata, T
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Takemasa, I
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Patel, P
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Vora, HH
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Shah, B
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Patel, JB
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Rajvik, KN
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Pandya, SJ
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Shukla, SN
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Wang, YL
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Zhang, GJ
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Kawakami, Y
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Marincola, FM
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Ascierto, PA
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Fox, BA
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Pages, F
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Galon, J
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