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Multivariable predi...
Multivariable prediction model for both 90-day mortality and long-term survival for individual patients with perihilar cholangiocarcinoma: does the predicted survival justify the surgical risk?
- Article/chapterEnglish2023
Publisher, publication year, extent ...
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2023-03-15
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Oxford University Press (OUP),2023
Numbers
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:152099073
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http://kipublications.ki.se/Default.aspx?queryparsed=id:152099073URI
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https://doi.org/10.1093/bjs/znad057DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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BackgroundThe risk of death after surgery for perihilar cholangiocarcinoma is high; nearly one in every five patients dies within 90 days after surgery. When the oncological benefit is limited, a high-risk resection may not be justified. This retrospective cohort study aimed to create two preoperative prognostic models to predict 90-day mortality and overall survival (OS) after major liver resection for perihilar cholangiocarcinoma.MethodsSeparate models were built with factors known before surgery using multivariable regression analysis for 90-day mortality and OS. Patients were categorized in three groups: favourable profile for surgical resection (90-day mortality rate below 10 per cent and predicted OS more than 3 years), unfavourable profile (90-day mortality rate above 25 per cent and/or predicted OS below 1.5 years), and an intermediate group.ResultsA total of 1673 patients were included. Independent risk factors for both 90-day mortality and OS included ASA grade III–IV, large tumour diameter, and right-sided hepatectomy. Additional risk factors for 90-day mortality were advanced age and preoperative cholangitis; those for long-term OS were high BMI, preoperative jaundice, Bismuth IV, and hepatic artery involvement. In total, 294 patients (17.6 per cent) had a favourable risk profile for surgery (90-day mortality rate 5.8 per cent and median OS 42 months), 271 patients (16.2 per cent) an unfavourable risk profile (90-day mortality rate 26.8 per cent and median OS 16 months), and 1108 patients (66.2 per cent) an intermediate risk profile (90-day mortality rate 12.5 per cent and median OS 27 months).ConclusionPreoperative risk models for 90-day mortality and OS can help identify patients with resectable perihilar cholangiocarcinoma who are unlikely to benefit from surgical resection. Tailored shared decision-making is particularly essential for the large intermediate group.
Added entries (persons, corporate bodies, meetings, titles ...)
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Buettner, S
(author)
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Erdmann, JI
(author)
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Pratschke, J
(author)
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Ratti, F
(author)
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Jarnagin, WR
(author)
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Schnitzbauer, AA
(author)
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Lang, H
(author)
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Ruzzenente, A
(author)
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Nadalin, S
(author)
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Cescon, M
(author)
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Topal, B
(author)
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Olthof, PB
(author)
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Koerkamp, BG
(author)
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In:The British journal of surgery: Oxford University Press (OUP)110:5, s. 599-6051365-21680007-1323
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van Keulen, AM
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Buettner, S
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Erdmann, JI
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Pratschke, J
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Ratti, F
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Jarnagin, WR
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Schnitzbauer, AA
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Lang, H
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Ruzzenente, A
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Nadalin, S
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Cescon, M
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Topal, B
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Olthof, PB
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Koerkamp, BG
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The British jour ...
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Karolinska Institutet