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Physical activity attenuates but does not eliminate coronary heart disease risk amongst adults with risk factors : EPIC-CVD case-cohort study
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- Fortuin-de Smidt, Melony C. (författare)
- Umeå University,Umeå universitet,Allmänmedicin
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- Sewe, Maquins Odhiambo (författare)
- Umeå University,Umeå universitet,Avdelningen för hållbar hälsa
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- Lassale, Camille (författare)
- Hospital del Mar Medical Research Institute,CIBER de Fisiopatología Obesidad y Nutricion (CIBEROBN)
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visa fler...
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- Weiderpass, Elisabete (författare)
- International Agency for Research on Cancer, World Health Organization
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- Andersson, Jonas, 1977- (författare)
- Umeå University,Umeå universitet,Avdelningen för medicin,Skellefteå Research Unit
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- Huerta, José María (författare)
- Murcia Regional Health Council,CIBER Epidemiology and Public Health (CIBERESP)
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- Ekelund, Ulf (författare)
- Norwegian Institute of Public Health,Norwegian School of Sport Sciences
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- Aleksandrova, Krasimira (författare)
- Leibniz Institute for Prevention Research and Epidemiology - BIPS GmbH,University of Bremen
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- Tong, Tammy Y.N. (författare)
- University of Oxford
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- Dahm, Christina C. (författare)
- Aarhus University
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- Tjønneland, Anne (författare)
- Danish Cancer Society,University of Copenhagen
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- Kyrø, Cecilie (författare)
- Danish Cancer Society
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- Steindorf, Karen (författare)
- German Cancer Research Centre
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- Schulze, Matthias B. (författare)
- University of Potsdam,German Institute of Human Nutrition
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- Katzke, Verena (författare)
- German Cancer Research Centre
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- Sacerdote, Carlotta (författare)
- Citta' della Salute e della Scienza Hospital-University of Turin
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- Agnoli, Claudia (författare)
- Istituto Nazionale dei Tumori
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- Masala, Giovanna (författare)
- Institute for Cancer Research, Prevention and Clinical Network (ISPRO)
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Tumino, Rosario (författare)
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- Panico, Salvatore (författare)
- University of Naples Federico II
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- Boer, Jolanda M.A. (författare)
- National Institute for Public Health and the Environment (RIVM),Catalan Institute of Oncology,Bellvitge Biomedical Research Institute
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- Onland-Moret, N. Charlotte (författare)
- University Medical Center Utrecht
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- Wendel-Vos, G.C. Wanda (författare)
- National Institute for Public Health and the Environment (RIVM)
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- van der Schouw, Yvonne T. (författare)
- University Medical Center Utrecht
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- Benjaminsen Borch, Kristin (författare)
- UiT The Arctic University of Norway, Tromsø
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Agudo, Antonio (författare)
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- Petrova, Dafina (författare)
- Andalusian School Of Public Health (EASP),CIBER Epidemiology and Public Health (CIBERESP)
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- Chirlaque, María-Dolores (författare)
- Murcia Regional Health Council,CIBER Epidemiology and Public Health (CIBERESP)
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- Conchi, Moreno-Iribas (författare)
- Health Research Institute of Navarra (IDISNA)
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- Amiano, Pilar (författare)
- Biodonostia Health Research Institute,CIBER Epidemiology and Public Health (CIBERESP)
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- Melander, Olle (författare)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Skåne University Hospital
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- Heath, Alicia K. (författare)
- Imperial College London
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- Aune, Dagfinn (författare)
- Karolinska Institute,Oslo university hospital,Imperial College London
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- Forouhi, Nita G. (författare)
- University of Cambridge
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- Langenberg, Claudia (författare)
- Berlin Institute of Health (BIH),University of Cambridge
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- Brage, Soren (författare)
- University of Cambridge
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- Riboli, Elio (författare)
- Imperial College London
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- Wareham, Nicholas J. (författare)
- University of Cambridge
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- Danesh, John (författare)
- University of Cambridge,Wellcome Trust Sanger Institute
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- Butterworth, Adam S. (författare)
- University of Cambridge
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- Wennberg, Patrik, 1972- (författare)
- Umeå University,Umeå universitet,Allmänmedicin
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(creator_code:org_t)
- 2022-04-11
- 2022
- Engelska.
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Ingår i: European Journal of Preventive Cardiology. - : Oxford University Press (OUP). - 2047-4873 .- 2047-4881. ; 29:12, s. 1618-1629
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- AIMS: This study aimed to evaluate the association between physical activity and the incidence of coronary heart disease (CHD) in individuals with and without CHD risk factors.METHODS AND RESULTS: EPIC-CVD is a case-cohort study of 29 333 participants that included 13 582 incident CHD cases and a randomly selected sub-cohort nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Self-reported physical activity was summarized using the Cambridge physical activity index (inactive, moderately inactive, moderately active, and active). Participants were categorized into sub-groups based on the presence or the absence of the following risk factors: obesity (body mass index ≥30 kg/m2), hypercholesterolaemia (total cholesterol ≥6.2 mmol/L), history of diabetes, hypertension (self-reported or ≥140/90 mmHg), and current smoking. Prentice-weighted Cox regression was used to assess the association between physical activity and incident CHD events (non-fatal and fatal).Compared to inactive participants without the respective CHD risk factor (referent), excess CHD risk was highest in physically inactive and lowest in moderately active participants with CHD risk factors. Corresponding excess CHD risk estimates amongst those with obesity were 47% [95% confidence interval (CI) 32-64%] and 21% (95%CI 2-44%), with hypercholesterolaemia were 80% (95%CI 55-108%) and 48% (95%CI 22-81%), with hypertension were 80% (95%CI 65-96%) and 49% (95%CI 28-74%), with diabetes were 142% (95%CI 63-260%), and 100% (95%CI 32-204%), and amongst smokers were 152% (95%CI 122-186%) and 109% (95%CI 74-150%).CONCLUSIONS: In people with CHD risk factors, moderate physical activity, equivalent to 40 mins of walking per day, attenuates but does not completely offset CHD risk.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Case-cohort study
- Coronary heart disease
- Physical activity
- Population preventable fraction
- Risk factors
- Case-cohort study
- Coronary heart disease
- Physical activity
- Population preventable fraction
- Risk factors
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Fortuin-de Smidt ...
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Sewe, Maquins Od ...
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Lassale, Camille
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Weiderpass, Elis ...
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Andersson, Jonas ...
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Huerta, José Mar ...
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Ekelund, Ulf
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Aleksandrova, Kr ...
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Tong, Tammy Y.N.
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Dahm, Christina ...
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Tjønneland, Anne
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Kyrø, Cecilie
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Steindorf, Karen
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Schulze, Matthia ...
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Katzke, Verena
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Sacerdote, Carlo ...
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Agnoli, Claudia
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Masala, Giovanna
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Tumino, Rosario
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Panico, Salvator ...
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Boer, Jolanda M. ...
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Onland-Moret, N. ...
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Wendel-Vos, G.C. ...
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van der Schouw, ...
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Benjaminsen Borc ...
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Agudo, Antonio
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Petrova, Dafina
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Chirlaque, María ...
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Conchi, Moreno-I ...
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Amiano, Pilar
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Melander, Olle
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Heath, Alicia K.
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Aune, Dagfinn
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Forouhi, Nita G.
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Langenberg, Clau ...
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Brage, Soren
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Riboli, Elio
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Wareham, Nichola ...
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Danesh, John
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Butterworth, Ada ...
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Wennberg, Patrik ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Folkhälsovetensk ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
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European Journal ...
- Av lärosätet
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Umeå universitet
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Lunds universitet
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Karolinska Institutet