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Prognostic significance of high hyperdiploid and triploid/tetraploid adult acute myeloid leukemia

Lazarevic, Vladimir (author)
Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Skane Univ Hosp, Dept Hematol & Vasc Dis, SE-22185 Lund, Sweden.;Lund Univ, Stem Cell Ctr, Lund, Sweden.,Skåne University Hospital, Sweden; Lund University, Sweden
Rosso, Aldana (author)
Lund University,Lunds universitet,Socialepidemiologi,Forskargrupper vid Lunds universitet,Social Epidemiology,Lund University Research Groups,Skane Univ Hosp, Epidemiol & Registry Ctr South Sweden, SE-22185 Lund, Sweden.,Skåne University Hospital, Sweden
Juliusson, Gunnar (author)
Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Skane Univ Hosp, Dept Hematol & Vasc Dis, SE-22185 Lund, Sweden.;Lund Univ, Stem Cell Ctr, Lund, Sweden.,Skåne University Hospital, Sweden; Lund University, Sweden
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Antunovic, Petar (author)
Linköpings universitet,Avdelningen för kliniska vetenskaper,Medicinska fakulteten,Region Östergötland, Hematologiska kliniken US,Department of Hematology, Linköping University Hospital, Linköping, Sweden,Linkoping Univ Hosp, Dept Hematol, S-58185 Linkoping, Sweden.
Rangert-Derolf, Asa (author)
Karolinska University Hospital, Sweden,Div Hematol Karolinska Univ Hosp Solna, Stockholm, Sweden; Div Hematol Karolinska Univ Hosp Huddinge, Stockholm, Sweden; Dept Med, Karolinska Univ Hosp, Stockholm, Sweden
Lehmann, Soren (author)
Karolinska Institutet,Uppsala universitet,Hematologi,Karolinska Univ Hosp, Div Hematol Stockholm & Huddinge, Dept Med, Karolinska, Sweden.,Karolinska University Hospital, Sweden
Mollgard, Lars (author)
Sahlgrens University Hospital, Sweden,Sahlgrens Univ Hosp, Dept Med, S-41345 Gothenburg, Sweden.
Uggla, Bertil (author)
Region Örebro län,Orebro Univ Hosp, Sch Hlth & Med Sci, Dept Med, Orebro, Sweden.,Örebro University Hospital, Sweden
Wennstrom, Lovisa (author)
Sahlgrens University Hospital, Sweden,Sahlgrens Univ Hosp, Dept Med, S-41345 Gothenburg, Sweden.
Wahlin, Anders (author)
Umeå universitet,Institutionen för strålningsvetenskaper,Umea Univ, Dept Radiat Sci, Umea, Sweden.,Umeå University, Sweden
Höglund, Martin (author)
Uppsala universitet,Hematologi,Academic Hospital, Sweden
Johansson, Bertil (author)
Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine,Univ & Reg Labs Reg Skane, Dept Clin Genet, Lund, Sweden.;Lund Univ, Div Clin Genet, Dept Lab Med, Lund, Sweden.,University of and Regional Labs Regional Skåne, Sweden; Lund University, Sweden
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 (creator_code:org_t)
2015-07-22
2015
English.
In: American Journal of Hematology. - : WILEY-BLACKWELL. - 0361-8609 .- 1096-8652. ; 90:9, s. 800-805
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • To ascertain the clinical implications of high hyperdiploid (HH; 49-65 chromosomes) and triploid/tetraploid (TT; greater than65 chromosomes) adult acute myeloid leukemia (AML), all such cases were retrieved from the Swedish AML Registry. Of the 3,654 cytogenetically informative cases diagnosed between January 1997 and May 2014, 68 (1.9%) were HH (n=50)/TT (n=18). Patients with HH/TT were older than those with intermediate risk (IR) AML (median 71 years vs. 67 years; P=0.042) and less often had de novo AML (63% vs. 79%; P=0.004); no such differences were observed between HH/TT and complex karyotype (CK) AML. The overall survival (OS) was similar between patients with HH/TT and CK AML (median 0.9 years vs. 0.6 years; P=0.082), whereas OS was significantly longer (median 1.6 years; P=0.028) for IR AML. The OS was shorter for cases with HH than with TT (median 0.6 years vs. 1.4 years; P=0.032) and for HH/TT AMLs with adverse abnormalities (median 0.8 years vs. 1.1 years; P=0.044). In conclusion, HH/TT AML is associated with a poor outcome, but chromosome numbers greater than65 and absence of adverse aberrations seem to translate into a more favorable prognosis. Thus, HH/TT AMLs are clinically heterogeneous and should not automatically be grouped as high risk.Am. J. Hematol. 90:800-805, 2015. (c) 2015 Wiley Periodicals, Inc.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Hematologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Hematology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

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